New horizons for the therapeutic application of nanozymes in cancer treatment

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 20, 2025

The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes

Language: Английский

Chlorin e6: a promising photosensitizer of anti-tumor and anti-inflammatory effects in PDT

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 29, 2025

Photodynamic therapy (PDT) involves the activation of photosensitizers (PSs) by visible laser light at target site to catalyze production reactive oxygen species, resulting in tumor cell death and blood vessel closure. The efficacy PDT depends on PSs, amount oxygen, intensity excitation laser. PSs have been extensively researched, great efforts made develop an ideal photosensitizer. Chlorin-e6 is FDA-approved second-generation that has attracted widespread research interest medical field, especially with respect antitumor anti-inflammatory activity. possesses advantages a large absorption coefficient, high strength, low residue body, relatively safety thus promising application prospects. Here we review use chlorin-e6 discuss prospects further development this technology.

Language: Английский

Regulation of Oxygen in the Tumor Microenvironment Synergizes with Immunotherapy to Suppress Tumor Progression

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(12), P. 357 - 357

Published: Nov. 25, 2024

Hypoxia represents a crucial characteristic of the tumor microenvironment, which is closely related to cell proliferation, angiogenesis, and metabolic responses. These factors will further promote progression, increase invasion, enhance metastasis potential. A hypoxic microenvironment also inhibit activity infiltrated immune cells in leading failure cancer immunotherapy. Additionally, contributes resistance conventional therapies leads unfavorable prognoses. This review discusses advancements strategies aimed at ameliorating hypoxia within modulating responses against tumors.

Language: Английский