Self-oxygenating nanoplatform integrating CRISPR/Cas9 gene editing and immune activation for highly efficient photodynamic therapy
Shi-Cheng Tian,
No information about this author
Xun-Huan Song,
No information about this author
Ke-Ke Feng
No information about this author
et al.
Journal of Colloid and Interface Science,
Journal Year:
2025,
Volume and Issue:
693, P. 137632 - 137632
Published: April 17, 2025
Language: Английский
Liquid metal-based nanocomposite with triple-amplified Fenton-like reaction for tumor chemodynamic/photothermal/immunotherapy
Chemical Engineering Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 163326 - 163326
Published: May 1, 2025
Language: Английский
Macrophage-Mediated Liquid Metal Nanoparticles for Enhanced Tumor Accumulation and Inhibition
ACS Biomaterials Science & Engineering,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
In
most
studies,
the
penetration
of
nanoparticles
into
tumors
was
mainly
dependent
on
enhanced
permeability
and
retention
(ERP)
effect.
However,
would
be
limited
by
tumor-dense
structure,
immune
system,
other
factors.
To
solve
these
problems,
macrophages
with
active
tropism
to
tumor
tissues,
loaded
photothermal
therapy,
chemotherapy
were
designed.
detail,
liquid
metal
(gallium
indium
alloy)
modified
mesoporous
silica
then
embedded
chemotherapeutic
drug
sorafenib
(LM@Si/SO)
for
therapy
chemotherapy.
After
that,
LM@Si/SO
carried
mouse
macrophage
RAW264.7
cell
line
(LM@Si/SO@R)
increase
accumulation
in
site
improve
microenvironment.
With
accumulation,
LM@Si/SO@R
exhibited
excellent
antitumor
ability
vitro
vivo.
Thus,
strategies
via
carrier
enhance
therapeutic
efficiency
had
potential
improvement
therapy.
Language: Английский
Copper and Nitrogen Codoped CDs for Alleviating the Damage of Reactive Oxygen Species for Cucumber Seedlings under Salt Stress
Chen Li,
No information about this author
Jieqiang Tan,
No information about this author
Zhiwei Zhang
No information about this author
et al.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 9, 2025
Dramatic
changes
in
climate
and
soil
environments
have
made
growing
conditions
for
crops
more
challenging.
These
are
subject
to
a
range
of
abiotic
stresses
different
environments,
which
can
lead
significant
yield
losses,
resulting
economic
environmental
damages.
Herein,
we
report
straightforward
one-pot
hydrothermal
method
creating
carbon
dots
codoped
with
copper
nitrogen
(Cu,N-CDs).
Under
salt
stress
conditions,
Cu,N-CDs
demonstrate
the
ability
alleviate
oxidative
damage
cucumber
seedlings
by
modulating
antioxidant
defense
mechanisms
scavenging
reactive
oxygen
species
(ROS).
Cucumber
seedling
biomass
accumulation
is
greatly
enhanced
treatment
presence
ROS
burst,
leading
notable
rise
dry
weight,
plant
height,
fresh
weight.
mitigate
activating
systems,
specifically
enhancing
activities
superoxide
dismutase
(+34.08%),
catalase
(+28.11%),
peroxidase
(+17.54%),
ascorbate
(+31.54%)
scavenge
ROS.
Furthermore,
enhance
levels
nonenzymatic
elements
within
system,
such
as
polyphenols
(+23.60%),
flavonoids
(+15.43%),
carotenoid
content
(+51.73%),
strengthen
against
Meanwhile,
induce
increase
soluble
sugar
protein
27.27
32.58%,
respectively,
improves
osmotic
pressure
well
tolerance
plants.
Additionally,
was
aided
photosynthetic
pigment
that
produce.
Language: Английский