Ultrasmall PtIr Bimetallic Nanozyme Treats Myocardial Infarction via Ischemic/Inflammatory Cardiac Microenvironment Remodeling DOI
Yuxuan Gong, Yao Xiao, Caiyan Zhao

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Myocardial infarction (MI) poses a serious threat to human health. MI induces oxidative damage and inflammation, leading myocardial death, scarring, ventricular remodeling. Nanozymes have shown potential alleviate reactive oxygen species (ROS)-induced treat cardiovascular diseases. In this study, we developed an ultrasmall PtIr bimetallic nanozyme MI. The exhibited robust superoxide dismutase- catalase-mimicking catalytic activities, modulating the conversion of excessive ROS into harmless products. Furthermore, treatment reduced levels apoptosis in cardiomyocyte AC16 cells under stress vitro, while increasing expression cardiomyocyte-related functional genes, including cTnT, cTnI, Cx43, ACTN2. It also maintained intracellular mitochondrial membrane potential, increased activity, protected structure. rat model, attenuated neutrophil extracellular trap formation, apoptosis, inflammation infarcted heart 1 week postadministration. Four weeks postadministration, significantly enhanced activity connectivity, infarct size fibrosis levels, microvascular density compared with phosphate-buffered saline or Ir treatment. Proteomic analysis revealed that proteins associated energy metabolism, function, contraction were upregulated, multiple pathways related function such as fatty acid β-oxidation citric cycle, enriched injection group. These results suggest remodels microenvironment by inflammatory response, repairing damaged myocardium, improving cardiac function. Our findings highlight promising therapeutic strategy for

Language: Английский

Ultrasmall PtIr Bimetallic Nanozyme Treats Myocardial Infarction via Ischemic/Inflammatory Cardiac Microenvironment Remodeling DOI
Yuxuan Gong, Yao Xiao, Caiyan Zhao

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Myocardial infarction (MI) poses a serious threat to human health. MI induces oxidative damage and inflammation, leading myocardial death, scarring, ventricular remodeling. Nanozymes have shown potential alleviate reactive oxygen species (ROS)-induced treat cardiovascular diseases. In this study, we developed an ultrasmall PtIr bimetallic nanozyme MI. The exhibited robust superoxide dismutase- catalase-mimicking catalytic activities, modulating the conversion of excessive ROS into harmless products. Furthermore, treatment reduced levels apoptosis in cardiomyocyte AC16 cells under stress vitro, while increasing expression cardiomyocyte-related functional genes, including cTnT, cTnI, Cx43, ACTN2. It also maintained intracellular mitochondrial membrane potential, increased activity, protected structure. rat model, attenuated neutrophil extracellular trap formation, apoptosis, inflammation infarcted heart 1 week postadministration. Four weeks postadministration, significantly enhanced activity connectivity, infarct size fibrosis levels, microvascular density compared with phosphate-buffered saline or Ir treatment. Proteomic analysis revealed that proteins associated energy metabolism, function, contraction were upregulated, multiple pathways related function such as fatty acid β-oxidation citric cycle, enriched injection group. These results suggest remodels microenvironment by inflammatory response, repairing damaged myocardium, improving cardiac function. Our findings highlight promising therapeutic strategy for

Language: Английский

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