Bioactive Glass Microscaffolds Fabricated by Two‐Photon Lithography DOI Creative Commons
Leonhard Hambitzer,

Jan Mathis Hornbostel,

L Roolfs

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Porous scaffolds made of bioactive glass (BG) are great interest for tissue engineering as they can bond to bone rapidly and promote new formation. Pores channels between 100 500 µm provide space cell intrusion nutrient supply, facilitating ingrowth vascularization. Furthermore, smaller pores structural features a few microns in size influence behavior, such adhesion osteogenic differentiation. Additive manufacturing (AM) is well suited fabricate geometries. However, microstructuring BG demanding common AM techniques unable achieve below µm. In this work, two‐photon lithography (TPL) used the first time structure with single‐micron features. A composite containing nanoparticles structured using TPL thermally processed receive scaffolds. The study demonstrates vitro bioactivity simulated body fluid (SBF) cytocompatibility toward human mesenchymal stromal cells (MSCs), making it suitable material engineering. This process will open toolbox variety existing particles be shaped small 6 broaden understanding scaffold design on behavior.

Language: Английский

Bioactive Glass Microscaffolds Fabricated by Two‐Photon Lithography DOI Creative Commons
Leonhard Hambitzer,

Jan Mathis Hornbostel,

L Roolfs

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Porous scaffolds made of bioactive glass (BG) are great interest for tissue engineering as they can bond to bone rapidly and promote new formation. Pores channels between 100 500 µm provide space cell intrusion nutrient supply, facilitating ingrowth vascularization. Furthermore, smaller pores structural features a few microns in size influence behavior, such adhesion osteogenic differentiation. Additive manufacturing (AM) is well suited fabricate geometries. However, microstructuring BG demanding common AM techniques unable achieve below µm. In this work, two‐photon lithography (TPL) used the first time structure with single‐micron features. A composite containing nanoparticles structured using TPL thermally processed receive scaffolds. The study demonstrates vitro bioactivity simulated body fluid (SBF) cytocompatibility toward human mesenchymal stromal cells (MSCs), making it suitable material engineering. This process will open toolbox variety existing particles be shaped small 6 broaden understanding scaffold design on behavior.

Language: Английский

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