Briefings in Functional Genomics, Journal Year: 2023, Volume and Issue: 22(6), P. 525 - 532
Published: Aug. 9, 2023
Abstract Coleoid cephalopods (octopus, squid and cuttlefish) have unusually complex nervous systems. The coleoid system is also the only one currently known to recode majority of expressed proteins through A-to-I RNA editing. deamination adenosine by deaminase acting on (ADAR) enzymes produces inosine, which interpreted as guanosine during translation. If this occurs in an open reading frame, case for tens thousands editing sites coleoids, it can encoded protein. Here, we describe recent findings aimed at deciphering mechanisms underlying high-level recoding its adaptive potential. We complement ADAR cephalopods, including a recently discovered novel domain sqADAR1. further summarize current evidence supporting role review studies showing that large proportion temperature-sensitive. Despite these new findings, governing high level remain poorly understood. Recent advances using genome may provide useful tools study animals.
Language: Английский