Causal relationship between 41 inflammatory factors, circulating white blood cells, and pruritus: A 2-sample bidirectional Mendelian randomization study DOI Creative Commons
Kaiyuan Zheng, Siyu Wang, Lianlin Zeng

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(50), P. e40894 - e40894

Published: Dec. 13, 2024

The influence of circulating white blood cells and inflammatory factors on pruritus is gradually recognized by the public, but specific causal relationship still unknown. In this study, we included cytokine profiles from 8293 healthy subjects, genetic data various ethnic ancestry backgrounds, including 746,667 individuals, 1370 patients European descent with for a bidirectional 2-sample Mendelian randomization (MR) analysis. We employed several robust statistical methods, inverse variance weighted, weighted median, MR-Egger method. further refined our analysis through meticulous sensitivity assessment using leave-one-out strategy, evaluated heterogeneity findings Cochran’s Q test, addressed potential pleiotropic effects intercept test. Ultimately, reverse MR was conducted to assess causation. Genetic prediction indicate positive correlation between eosinophil cell count risk developing (odds ratio [OR] = 1.31, 95% confidence interval [CI] 1.09–1.55, P .003). Furthermore, elevated levels stromal-cell-derived factor 1 alpha (OR 1.80, CI: 1.15–2.77, .009), monokine induced gamma interferon 1.23, 1.04–1.46, .015), cutaneous T-cell-attracting chemokine 1.24, 1.01–1.53, .043) are all associated an increased occurrence, respectively. No evidence horizontal pleiotropy or observed among variants ( > .05), confirmed stability robustness association. demonstrated absence causality. Our research delineates links count, alpha, interferon, levels, susceptibility. These insights may present promising avenues enhancing management therapeutic strategies suffering pruritus.

Language: Английский

The today and tomorrow of (almost) each itch DOI Creative Commons

Zuzanna Frydrych,

Karolina Błaszak,

Rafał Czajkowski

et al.

Forum Dermatologicum, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Itch is an unpleasant sensation on the skin that causes desire to scratch. Its aetiology can be defined by various categories such as cause, period of occurrence, location, and presence or absence disease in a given area. This burdensome symptom experience even compared chronic pain terms quality-of-life-impairment particularly common among older people. article discusses neural pathways cause itch, important but clinically challenging role histamine, some mechanisms involved itch-scratch cycle, quite novel discoveries regarding contributions gastrin-releasing peptide (GRP)/ receptor (GRPR) axis, transient potential (TRP) channels, Janus kinase. Pruritus may associated with types diseases affecting maternal-foetal relationship, skin, cholestasis, renal system mental health. Some new therapeutic options include drugs affect opioid receptors, neurokinin 1 (NK-1R) antagonists, kinase inhibitors, biologics made combining antibodies against different interleukins itch sensation. Nevertheless, finding effective form therapy for patients underlying conditions remains challenge subject ongoing clinical research.

Language: Английский

Citations

0
Cutaneous Manifestations of Liver Disease: A Narrative Review DOI Open Access

S Jiménez

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Chronic liver disease is a major cause of morbidity and mortality. The most common extrahepatic manifestations are dermatological. pathophysiology these dermatological not clear, but it postulated that the mechanisms involved include generalized vasodilatation, hyperdynamic blood circulation, altered estrogen metabolism. cutaneous Terry's nails pruritus. consist leukonychia with distal pink band absence lunula. main differential diagnosis Lindsay's nails. Vascular palmar erythema arachnoid nevi, latter located in vascular territory superior vena cava occurring chronic alcohol-associated disease. Dermatological generally resolve improvement or remission disease, there no specific treatment for them. However, bile acid chelators first line cholestatic Studying contributes to early treatment, potentially improving patient's prognosis.

Language: Английский

Citations

0
Causal relationship between 41 inflammatory factors, circulating white blood cells, and pruritus: A 2-sample bidirectional Mendelian randomization study DOI Creative Commons
Kaiyuan Zheng, Siyu Wang, Lianlin Zeng

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(50), P. e40894 - e40894

Published: Dec. 13, 2024

The influence of circulating white blood cells and inflammatory factors on pruritus is gradually recognized by the public, but specific causal relationship still unknown. In this study, we included cytokine profiles from 8293 healthy subjects, genetic data various ethnic ancestry backgrounds, including 746,667 individuals, 1370 patients European descent with for a bidirectional 2-sample Mendelian randomization (MR) analysis. We employed several robust statistical methods, inverse variance weighted, weighted median, MR-Egger method. further refined our analysis through meticulous sensitivity assessment using leave-one-out strategy, evaluated heterogeneity findings Cochran’s Q test, addressed potential pleiotropic effects intercept test. Ultimately, reverse MR was conducted to assess causation. Genetic prediction indicate positive correlation between eosinophil cell count risk developing (odds ratio [OR] = 1.31, 95% confidence interval [CI] 1.09–1.55, P .003). Furthermore, elevated levels stromal-cell-derived factor 1 alpha (OR 1.80, CI: 1.15–2.77, .009), monokine induced gamma interferon 1.23, 1.04–1.46, .015), cutaneous T-cell-attracting chemokine 1.24, 1.01–1.53, .043) are all associated an increased occurrence, respectively. No evidence horizontal pleiotropy or observed among variants ( > .05), confirmed stability robustness association. demonstrated absence causality. Our research delineates links count, alpha, interferon, levels, susceptibility. These insights may present promising avenues enhancing management therapeutic strategies suffering pruritus.

Language: Английский

Citations

0