The impact of oral cannabis consumption during pregnancy on maternal spiral artery remodelling, fetal growth and offspring behaviour in mice

EBioMedicine, Journal Year: 2025, Volume and Issue: unknown, P. 105572 - 105572

Published: Feb. 1, 2025

SummaryBackgroundThe use of cannabis during pregnancy is rising following its widespread legalization. Cannabidiol (CBD) gaining popularity due to the public perception that it safer than psychoactive component Δ9-tetrahydrocannabinol (THC). However, while evidence underpins harm THC and smoke on fetal development, there minimal research safety CBD oral cannabis. The current study aims decipher pregnancy.MethodsUsing a mouse model, we directly compared effects oil exposure (20 mg/kg body weight) from early mid-gestation implantation site remodelling growth. We examined offspring behaviour metabolic activity using both traditional automated cage systems. Lastly, human immune cells assessed how influence angiogenic factor production.FindingsWe observed impaired maternal spiral artery in exposed mice found disrupt cell production. Oral consumption or also resulted significant growth impairment led long-lasting sex-dependent consequences as male exhibited altered aggression females had spatial learning.InterpretationOur results show either developing fetus causes behavioural changes after birth.FundingThe Michael G. DeGroote Centre for Medicinal Cancer Research, Canadian Institutes Health Foundation Innovation.

Language: Английский

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“I don’t need my kid to be high”: prioritizing harm reduction when using cannabis during pregnancy

Harm Reduction Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Sept. 9, 2024

Language: Английский

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Harm reduction for perinatal cannabis use: protocol for a scoping review of clinical practices

BMJ Open, Journal Year: 2024, Volume and Issue: 14(12), P. e090453 - e090453

Published: Dec. 1, 2024

Introduction The American College of Obstetricians and Gynaecologists recommends against cannabis use during pregnancy lactation (‘perinatal use’) given its association with negative parent–child health outcomes. However, is becoming increasingly available used pregnancy, perceptions safety are correspondingly increasing. For individuals who unable or unwilling to cease lactation, harm reduction the best evidence-based practice promote health. Further, there have been calls for increased employment perinatal use. field currently lacks understanding what this population looks like in practice. Likely contributing lack fact that concept not consistently defined, strategies comprise may always be labelled as such. This makes it challenging comprehensively collect articles using search terms meant pull specifically. aim scoping review all discussing published since discovery endocannabinoid system, then screen references describe concrete clinical practices population. Methods analysis Joanna Briggs Institute (JBI) Manual Evidence Synthesis Arksey O’Malley methodology reviews, updated by Levac colleagues, guide review. protocol reported Preferred Reporting Items Systematic Reviews Meta-Analyses Scoping (PRISMA-ScR). A systematic literature was initially conducted identify English-language authored between January 1990 2023 present these databases 22 September 2023: PubMed (National Library Medicine), Embase (Elsevier), Web Science Core Collection (Clarivate), APA PsycINFO (EBSCO), CINAHL(EBSCO) Cochrane Central Register Controlled Trials (CENTRAL) (Wiley). Preceding submission results publication, will run again order ensure capturing later publications relevant Google also hand-searched patient-facing materials. Additional grey sources include trials, preprints conference proceedings were excluded from database results. We ‘bookend’ our present, 1990s saw first passing legalised medical USA. Literature eligible inclusion if includes a description approaches Two reviewers independently complete title/abstract screening followed full-text meet criteria. Data, including practice(s), dates data collection, when where reference published, legal status place collected any outcomes associated extracted studies remain after appraised quality Mixed Appraisal Tool (MMAT). Ethics dissemination approval sought does constitute collection on human subjects (no information specimens interaction intervention an individual). systematically examine scope coverage existing harm-reduction research Findings inform elucidate future directions research. study team themselves actively engaged treating patients they participate activities allow findings reach other providers (eg, presentations, publications). Study registration Registered Open Framework (OSF Registries; https://osf.io/wb3jc ).

Language: Английский

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Sociodemographic Differences in Modes of Cannabis Use Among Pregnant Individuals in Northern California

Drug and Alcohol Dependence, Journal Year: 2024, Volume and Issue: 267, P. 112546 - 112546

Published: Dec. 28, 2024

Language: Английский

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