
Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 429 - 429
Published: Jan. 20, 2025
Liver-expressed antimicrobial peptide 2 (LEAP-2) was originally discovered as an that plays a vital role in the host innate immune system of various vertebrates. Recent research LEAP-2 endogenous antagonist and inverse agonist GHSR1a receptor. By acting competitive to ghrelin, influences energy balance metabolic processes via ghrelin–GHSR1a signaling pathway. alone or LEAP-2/ghrelin molar ratio showed potential therapeutic targets for obesity, diabetes, disorders. This review explores recent advances modulation regulation, highlighting its treating above diseases.
Language: Английский