Peptide with Dual Roles in Immune and Metabolic Regulation: Liver-Expressed Antimicrobial Peptide-2 (LEAP-2) DOI Creative Commons
Yitong Li, Ying Liu, Meng Gou

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 429 - 429

Published: Jan. 20, 2025

Liver-expressed antimicrobial peptide 2 (LEAP-2) was originally discovered as an that plays a vital role in the host innate immune system of various vertebrates. Recent research LEAP-2 endogenous antagonist and inverse agonist GHSR1a receptor. By acting competitive to ghrelin, influences energy balance metabolic processes via ghrelin–GHSR1a signaling pathway. alone or LEAP-2/ghrelin molar ratio showed potential therapeutic targets for obesity, diabetes, disorders. This review explores recent advances modulation regulation, highlighting its treating above diseases.

Language: Английский

Peptide with Dual Roles in Immune and Metabolic Regulation: Liver-Expressed Antimicrobial Peptide-2 (LEAP-2) DOI Creative Commons
Yitong Li, Ying Liu, Meng Gou

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 429 - 429

Published: Jan. 20, 2025

Liver-expressed antimicrobial peptide 2 (LEAP-2) was originally discovered as an that plays a vital role in the host innate immune system of various vertebrates. Recent research LEAP-2 endogenous antagonist and inverse agonist GHSR1a receptor. By acting competitive to ghrelin, influences energy balance metabolic processes via ghrelin–GHSR1a signaling pathway. alone or LEAP-2/ghrelin molar ratio showed potential therapeutic targets for obesity, diabetes, disorders. This review explores recent advances modulation regulation, highlighting its treating above diseases.

Language: Английский

Citations

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