How life events may confer vulnerability to addiction: the role of epigenetics DOI Creative Commons
Shirelle X. Liu, Andrew C. Harris,

Jonathan C. Gewirtz

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Sept. 18, 2024

Substance use disorder (SUD) represents a large and growing global health problem. Despite the strong addictive potency of drugs abuse, only minority those exposed develop SUDs. While certain life experiences (e.g., childhood trauma) may increase subsequent vulnerability to SUDs, mechanisms underlying these effects are not yet well understood. Given chronic relapsing nature length time that can elapse between prior events drug exposure, changes in SUD almost certainly involve long-term epigenetic dysregulation. To validate this idea, functional specific modifications brain regions mediating reinforcement learning nucleus accumbens, prefrontal cortex) have been investigated variety animal models In addition, produced by on studied, but mostly correlational manner. Here, we review how impact SUD-related behavior summarize our understanding relationships among experiences, regulation, future variations study design, most consistently affect produce predominantly unidirectional gene such as DNA methylation histone phosphorylation. Evidence explicitly linking environmentally induced is surprisingly sparse. We conclude offering several directions for research begin address critical gap.

Language: Английский

How life events may confer vulnerability to addiction: the role of epigenetics DOI Creative Commons
Shirelle X. Liu, Andrew C. Harris,

Jonathan C. Gewirtz

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Sept. 18, 2024

Substance use disorder (SUD) represents a large and growing global health problem. Despite the strong addictive potency of drugs abuse, only minority those exposed develop SUDs. While certain life experiences (e.g., childhood trauma) may increase subsequent vulnerability to SUDs, mechanisms underlying these effects are not yet well understood. Given chronic relapsing nature length time that can elapse between prior events drug exposure, changes in SUD almost certainly involve long-term epigenetic dysregulation. To validate this idea, functional specific modifications brain regions mediating reinforcement learning nucleus accumbens, prefrontal cortex) have been investigated variety animal models In addition, produced by on studied, but mostly correlational manner. Here, we review how impact SUD-related behavior summarize our understanding relationships among experiences, regulation, future variations study design, most consistently affect produce predominantly unidirectional gene such as DNA methylation histone phosphorylation. Evidence explicitly linking environmentally induced is surprisingly sparse. We conclude offering several directions for research begin address critical gap.

Language: Английский

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