Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(10), P. 823 - 823
Published: May 8, 2024
Understanding
both
the
physicochemical
and
biological
interactions
of
nanoparticles
is
mandatory
for
biomedical
application
nanomaterials.
By
binding
proteins,
acquire
new
surface
identities
in
fluids,
protein
corona.
Various
studies
have
revealed
dynamic
structure
nano–bio
The
proteins
not
only
imparts
to
fluids
but
also
significantly
influences
their
bioactivity,
stability,
targeting
specificity.
Interestingly,
recent
endeavors
been
undertaken
harness
potential
corona
instead
evading
its
presence.
Exploitation
this
‘protein–nanoparticle
alliance’
has
significant
change
field
nanomedicine.
Here,
we
present
a
thorough
examination
latest
research
on
corona,
encompassing
formation,
dynamics,
developments,
diverse
bioapplications.
Furthermore,
aim
explore
at
interface,
paving
way
innovative
strategies
advance
addressing
challenges
promises
controlling
review
provides
insights
into
evolving
landscape
highlights
emerging.
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
657, P. 124163 - 124163
Published: April 25, 2024
Parenteral
administration
is
one
of
the
most
commonly
used
drug
delivery
routes
for
nanoparticle-based
dosage
forms,
such
as
lipid-based
and
polymeric
nanoparticles.
For
treatment
various
diseases,
parenteral
include
intravenous,
subcutaneous,
intramuscular
route.
In
development
phase,
multiparameter
strategy
with
a
focus
on
physicochemical
properties
specificity
route
required.
Nanoparticle
in
terms
size
targeted
delivery,
among
others,
are
able
to
surpass
many
drawbacks
conventional
but
these
unique
can
be
bottleneck
approval
by
regulatory
authorities.
Quality
Design
(QbD)
approach
has
been
widely
utilized
forms.
It
fosters
knowledge
product
process
quality
involving
sound
scientific
data
risk
assessment
strategies.
A
full
comprehensive
investigation
into
state
implementation
applications
QbD
complex
products
highlight
gaps
challenges.
this
review,
analysis
critical
attributes
Experiment
(DoE)
different
nanoparticulate
systems,
together
proper
utilization
Process
Analytical
Technology
(PAT)
described.
The
essential
design
forms
via
discussed
thoroughly.
Gels,
Journal Year:
2024,
Volume and Issue:
10(4), P. 284 - 284
Published: April 22, 2024
Various
controlled
delivery
systems
(CDSs)
have
been
developed
to
overcome
the
shortcomings
of
traditional
drug
formulations
(tablets,
capsules,
syrups,
ointments,
etc.).
Among
innovative
CDSs,
hydrogels
and
liposomes
shown
great
promise
for
clinical
applications
thanks
their
cost-effectiveness,
well-known
chemistry
synthetic
feasibility,
biodegradability,
biocompatibility
responsiveness
external
stimuli.
To
date,
several
liposomal-
hydrogel-based
products
approved
treat
cancer,
as
well
fungal
viral
infections,
hence
integration
into
has
attracted
increasing
attention
because
benefit
from
both
them
a
single
platform,
resulting
in
multifunctional
formulation,
which
is
essential
develop
efficient
CDSs.
This
short
review
aims
present
an
updated
report
on
advancements
liposome-hydrogel
purposes.
Advanced Drug Delivery Reviews,
Journal Year:
2024,
Volume and Issue:
213, P. 115419 - 115419
Published: Aug. 5, 2024
RNA
medicines
represent
a
paradigm
shift
in
treatment
and
prevention
of
critical
diseases
global
significance,
e.g.,
infectious
diseases.
The
highly
successful
messenger
(mRNA)
vaccines
against
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
were
developed
at
record
speed
during
the
disease
2019
pandemic.
A
consequence
this
is
exceptionally
shortened
vaccine
development
times,
which
combination
with
adaptability
makes
technology
attractive
for
pandemic
preparedness.
Here,
we
review
state
art
design
delivery
based
on
different
modalities,
including
linear
mRNA,
self-amplifying
RNA,
trans-amplifying
circular
RNA.
We
provide
an
overview
clinical
pipeline
diseases,
present
analytical
procedures,
are
paramount
characterizing
quality
attributes
guaranteeing
their
quality,
discuss
future
perspectives
using
to
combat
pathogens
beyond
SARS-CoV-2.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(10), P. 823 - 823
Published: May 8, 2024
Understanding
both
the
physicochemical
and
biological
interactions
of
nanoparticles
is
mandatory
for
biomedical
application
nanomaterials.
By
binding
proteins,
acquire
new
surface
identities
in
fluids,
protein
corona.
Various
studies
have
revealed
dynamic
structure
nano–bio
The
proteins
not
only
imparts
to
fluids
but
also
significantly
influences
their
bioactivity,
stability,
targeting
specificity.
Interestingly,
recent
endeavors
been
undertaken
harness
potential
corona
instead
evading
its
presence.
Exploitation
this
‘protein–nanoparticle
alliance’
has
significant
change
field
nanomedicine.
Here,
we
present
a
thorough
examination
latest
research
on
corona,
encompassing
formation,
dynamics,
developments,
diverse
bioapplications.
Furthermore,
aim
explore
at
interface,
paving
way
innovative
strategies
advance
addressing
challenges
promises
controlling
review
provides
insights
into
evolving
landscape
highlights
emerging.
