Acta Pharmaceutica Sinica B,
Journal Year:
2022,
Volume and Issue:
12(5), P. 2206 - 2223
Published: Jan. 4, 2022
Looking
retrospectively
at
the
development
of
humanity,
vaccination
is
an
unprecedented
medical
landmark
that
saves
lives
by
harnessing
human
immune
system.
During
ongoing
coronavirus
disease
2019
(COVID-19)
pandemic,
still
most
effective
defense
modality.
The
successful
clinical
application
lipid
nanoparticle-based
Pfizer/BioNTech
and
Moderna
mRNA
COVID-19
vaccines
highlights
promising
future
nanotechnology
in
vaccine
development.
Compared
with
conventional
vaccines,
nanovaccines
are
supposed
to
have
advantages
lymph
node
accumulation,
antigen
assembly,
presentation;
they
also
have,
unique
pathogen
biomimicry
properties
because
well-organized
combination
multiple
factors.
Beyond
infectious
diseases,
exhibits
considerable
potential
for
cancer
treatment.
ultimate
goal
fully
mobilize
potency
system
as
a
living
therapeutic
recognize
tumor
antigens
eliminate
cells,
nanotechnologies
requisite
realize
this
goal.
In
review,
we
summarize
recent
advances
from
prevention
immunotherapy
highlight
different
types
materials,
mechanisms,
administration
methods,
well
perspectives.
Pharmaceutics,
Journal Year:
2021,
Volume and Issue:
13(2), P. 206 - 206
Published: Feb. 2, 2021
There
has
been
increased
interest
in
the
development
of
RNA-based
vaccines
for
protection
against
various
infectious
diseases
and
also
cancer
immunotherapies.
Rapid
cost-effective
manufacturing
methods
addition
to
potent
immune
responses
observed
preclinical
clinical
studies
have
made
mRNA-based
promising
alternatives
conventional
vaccine
technologies.
However,
efficient
delivery
these
requires
that
mRNA
be
protected
extracellular
degradation.
Lipid
nanoparticles
(LNPs)
extensively
studied
as
non-viral
vectors
target
cells
because
their
relatively
easy
scalable
processes.
This
review
highlights
key
advances
LNPs
reviews
application
formulated
use
cancer.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(51)
Published: May 17, 2023
Abstract
Messenger
RNA
(mRNA)
has
received
great
attention
in
the
prevention
and
treatment
of
various
diseases
due
to
success
coronavirus
disease
2019
(COVID‐19)
mRNA
vaccines
(Comirnaty
Spikevax).
To
meet
therapeutic
purpose,
it
is
required
that
must
enter
target
cells
express
sufficient
proteins.
Therefore,
development
effective
delivery
systems
necessary
crucial.
Lipid
nanoparticle
(LNP)
represents
a
remarkable
vehicle
indeed
accelerated
applications
humans,
as
several
mRNA‐based
therapies
have
already
been
approved
or
are
clinical
trials.
In
this
review,
focus
on
mRNA‐LNP‐mediated
anticancer
therapy.
It
summarizes
main
strategies
mRNA‐LNP
formulations,
discusses
representative
approaches
cancer,
points
out
current
challenges
possible
future
directions
research
field.
hoped
these
delivered
messages
can
help
further
improve
application
technology
cancer
Pharmaceutics,
Journal Year:
2020,
Volume and Issue:
12(9), P. 837 - 837
Published: Sept. 1, 2020
Nanotechnologies
have
attracted
increasing
attention
in
their
application
medicine,
especially
the
development
of
new
drug
delivery
systems.
With
help
nano-sized
carriers,
drugs
can
reach
specific
diseased
areas,
prolonging
therapeutic
efficacy
while
decreasing
undesired
side-effects.
In
addition,
recent
nanotechnological
advances,
such
as
surface
stabilization
and
stimuli-responsive
functionalization
also
significantly
improved
targeting
capacity
nanocarrier
assisted
system.
this
review,
we
evaluate
advances
different
nanocarriers
applications
therapeutics
delivery.
Science,
Journal Year:
2023,
Volume and Issue:
381(6656), P. 436 - 443
Published: July 27, 2023
Hematopoietic
stem
cells
(HSCs)
are
the
source
of
all
blood
over
an
individual's
lifetime.
Diseased
HSCs
can
be
replaced
with
gene-engineered
or
healthy
through
HSC
transplantation
(HSCT).
However,
current
protocols
carry
major
side
effects
and
have
limited
access.
We
developed
CD117/LNP-messenger
RNA
(mRNA),
a
lipid
nanoparticle
(LNP)
that
encapsulates
mRNA
is
targeted
to
cell
factor
receptor
(CD117)
on
HSCs.
Delivery
anti-human
CD117/LNP-based
editing
system
yielded
near-complete
correction
hematopoietic
sickle
cells.
Furthermore,
in
vivo
delivery
pro-apoptotic
PUMA
(p53
up-regulated
modulator
apoptosis)
CD117/LNP
affected
function
permitted
nongenotoxic
conditioning
for
HSCT.
The
ability
target
offers
regimen
HSCT,
this
platform
could
basis
genome
cure
genetic
disorders,
which
would
abrogate
need
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Feb. 21, 2024
Abstract
Inflammation-associated
diseases
encompass
a
range
of
infectious
and
non-infectious
inflammatory
diseases,
which
continuously
pose
one
the
most
serious
threats
to
human
health,
attributed
factors
such
as
emergence
new
pathogens,
increasing
drug
resistance,
changes
in
living
environments
lifestyles,
aging
population.
Despite
rapid
advancements
mechanistic
research
development
for
these
current
treatments
often
have
limited
efficacy
notable
side
effects,
necessitating
more
effective
targeted
anti-inflammatory
therapies.
In
recent
years,
nanotechnology
has
provided
crucial
technological
support
prevention,
treatment,
detection
inflammation-associated
diseases.
Various
types
nanoparticles
(NPs)
play
significant
roles,
serving
vaccine
vehicles
enhance
immunogenicity
carriers
improve
targeting
bioavailability.
NPs
can
also
directly
combat
pathogens
inflammation.
addition,
facilitated
biosensors
pathogen
imaging
techniques
This
review
categorizes
characterizes
different
NPs,
summarizes
their
applications
It
discusses
challenges
associated
with
clinical
translation
this
field
explores
latest
developments
prospects.
conclusion,
opens
up
possibilities
comprehensive
management
Science,
Journal Year:
2022,
Volume and Issue:
377(6604)
Published: July 21, 2022
To
accelerate
the
translation
of
cancer
nanomedicine,
we
used
an
integrated
genomic
approach
to
improve
our
understanding
cellular
processes
that
govern
nanoparticle
trafficking.
We
developed
a
massively
parallel
screen
leverages
barcoded,
pooled
cell
lines
annotated
with
multiomic
data
investigate
association
patterns
across
library
spanning
range
formulations
clinical
potential.
identified
both
materials
properties
and
cell-intrinsic
features
mediate
nanoparticle-cell
association.
Using
machine
learning
algorithms,
constructed
trafficking
networks
nanoparticle-specific
biomarkers.
validated
one
such
biomarker:
gene
expression
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: June 14, 2022
Abstract
In
the
last
decade,
development
of
messenger
RNA
(mRNA)
therapeutics
by
lipid
nanoparticles
(LNP)
leads
to
facilitate
clinical
trial
recruitment,
which
improves
efficacy
treatment
modality
a
large
extent.
Although
mRNA-LNP
vaccine
platforms
for
COVID-19
pandemic
demonstrated
high
efficiency,
safety
and
adverse
effects
challenges
due
uncontrolled
immune
responses
inappropriate
pharmacological
interventions
could
limit
this
tremendous
efficacy.
The
current
study
reveals
interplay
with
LNP
compositions
characterization
clarifies
interaction
dendritic,
macrophages,
neutrophile
cells,
complement.
Then,
profiles
delivery,
including
pharmacokinetics
cellular
trafficking,
were
discussed
in
detail
cancer
types
infectious
diseases.
This
review
opens
new
vital
landscape
improve
multidisciplinary
on
through
modulation
immunopharmacological
trials.
Graphical
Theranostics,
Journal Year:
2022,
Volume and Issue:
12(17), P. 7509 - 7531
Published: Jan. 1, 2022
Lipid
nanoparticles
(LNPs)
have
been
one
of
the
most
successful
nano-delivery
vehicles
that
enable
efficient
delivery
cytotoxic
chemotherapy
agents,
antibiotics,
and
nucleic
acid
therapeutics.During
coronavirus
disease
(COVID-19)
pandemic,
LNP-based
COVID-19
messenger
RNA
(mRNA)
vaccines
from
Pfizer/BioNTech
Moderna
successfully
developed,
resulting
in
global
sales
$37
billion
$17.7
billion,
respectively,
2021.Based
on
this
success,
development
multiple
therapeutics
is
gaining
momentum
due
to
its
potential
for
various
genetic
diseases
cancers.Furthermore,
imaging
techniques
can
be
utilized
evaluate
pharmacokinetics
pharmacodynamics
(PK/PD)
effects,
which
helps
target
discovery
accelerates
mRNA
therapies.A
thorough
introduction
explanation
components
LNPs
functions
along
with
production
methods
formulating
are
provided
review.Furthermore,
recent
advances
clinics
clinical
trials
explored.Additionally,
evaluation
PK/PD
current
roles
developing
pharmaceutics
through
will
discussed.
