Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: May 6, 2022
Abstract
IRE1α
is
constitutively
active
in
several
cancers
and
can
contribute
to
cancer
progression.
Activated
cleaves
XBP1
mRNA,
a
key
step
production
of
the
transcription
factor
XBP1s.
In
addition,
select
mRNAs
through
regulated
IRE1α-dependent
decay
(RIDD).
Accumulating
evidence
implicates
regulation
lipid
metabolism.
However,
roles
XBP1s
RIDD
this
process
remain
ill-defined.
study,
transcriptome
lipidome
profiling
triple
negative
breast
cells
subjected
pharmacological
inhibition
reveals
changes
metabolism
genes
associated
with
accumulation
triacylglycerols
(TAGs).
We
identify
DGAT2
encoding
rate-limiting
enzyme
TAG
biosynthesis,
as
target.
Inhibition
IRE1α,
leads
DGAT2-dependent
TAGs
droplets
sensitizes
nutritional
stress,
which
rescued
by
treatment
inhibitor
PF-06424439.
Our
results
highlight
importance
activity
reprograming
cellular
Cancer & Metabolism,
Journal Year:
2021,
Volume and Issue:
9(1)
Published: Jan. 7, 2021
Tumor
cellular
metabolism
exhibits
distinguishing
features
that
collectively
enhance
biomass
synthesis
while
maintaining
redox
balance
and
homeostasis.
These
attributes
reflect
the
complex
interactions
between
cell-intrinsic
factors
such
as
genomic-transcriptomic
regulation
cell-extrinsic
influences,
including
growth
factor
nutrient
availability.
Alongside
glucose
amino
acid
metabolism,
fatty
supports
tumorigenesis
disease
progression
through
a
range
of
processes
membrane
biosynthesis,
energy
storage
production,
generation
signaling
intermediates.
Here,
we
highlight
complexity
in
cancer,
various
inputs
outputs
intracellular
free
pool,
numerous
ways
these
pathways
influence
behavior.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(3), P. 1155 - 1155
Published: Jan. 21, 2022
Cancer
has
long
been
considered
a
genetic
disease
characterized
by
myriad
of
mutations
that
drive
cancer
progression.
Recent
accumulating
evidence
indicates
the
dysregulated
metabolism
in
cells
is
more
than
hallmark
but
may
be
underlying
cause
tumor.
Most
well-characterized
oncogenes
or
tumor
suppressor
genes
function
to
sustain
altered
metabolic
state
cancer.
Here,
we
review
supporting
including
key
alterations
glucose,
glutamine,
and
fatty
acid
metabolism.
Unlike
do
not
occur
all
types,
are
common
among
subtypes
across
cancers.
Recognizing
as
disorder
could
unravel
diagnostic
treatments
markers
can
impact
approaches
used
management.
Journal of Hematology & Oncology,
Journal Year:
2023,
Volume and Issue:
16(1)
Published: Sept. 12, 2023
Abstract
Lipid
metabolic
reprogramming
is
an
emerging
hallmark
of
cancer.
In
order
to
sustain
uncontrolled
proliferation
and
survive
in
unfavorable
environments
that
lack
oxygen
nutrients,
tumor
cells
undergo
transformations
exploit
various
ways
acquiring
lipid
increasing
oxidation.
addition,
stromal
immune
the
microenvironment
also
reprogramming,
which
further
affects
functional
phenotypes
responses.
Given
metabolism
plays
a
critical
role
supporting
cancer
progression
remodeling
microenvironment,
targeting
pathway
could
provide
novel
approach
treatment.
This
review
seeks
to:
(1)
clarify
overall
landscape
mechanisms
cancer,
(2)
summarize
landscapes
within
their
roles
progression,
(3)
potential
therapeutic
targets
for
metabolism,
highlight
combining
such
approaches
with
other
anti-tumor
therapies
new
opportunities
patients.
Oncogenesis,
Journal Year:
2022,
Volume and Issue:
11(1)
Published: Aug. 9, 2022
Abstract
Lipids
are
essential
constituents
for
malignant
tumors,
as
they
absolutely
required
tumor
growth
and
dissemination.
Provided
by
the
microenvironment
(TME)
or
cancer
cells
themselves
through
activation
of
de
novo
synthesis
pathways,
orchestrate
a
large
variety
pro-tumorigenic
functions.
Importantly,
TME
cells,
especially
immune
cancer-associated
fibroblasts
(CAFs)
adipocytes
(CAAs),
also
prone
to
changes
in
their
lipid
content,
which
hinder
promote
aggressiveness.
In
this
review,
we
address
significant
findings
contribution
progression
towards
metastatic
disease
poor
response
therapeutic
treatments.
We
highlight
benefits
targeting
pathways
preclinical
models
slow
down
metastasis
development
overcome
chemo-and
immunotherapy
resistance.
Mass Spectrometry Reviews,
Journal Year:
2022,
Volume and Issue:
43(2), P. 235 - 268
Published: Sept. 6, 2022
Abstract
Mass
spectrometry
(MS)
has
become
a
central
technique
in
cancer
research.
The
ability
to
analyze
various
types
of
biomolecules
complex
biological
matrices
makes
it
well
suited
for
understanding
biochemical
alterations
associated
with
disease
progression.
Different
samples,
including
serum,
urine,
saliva,
and
tissues
have
been
successfully
analyzed
using
mass
spectrometry.
In
particular,
spatial
metabolomics
MS
imaging
(MSI)
allows
the
direct
visualization
metabolite
distributions
tissues,
thus
enabling
in‐depth
cancer‐associated
changes
within
specific
structures.
recent
years,
MSI
studies
increasingly
used
uncover
metabolic
reprogramming
development,
discovery
key
biomarkers
potential
diagnostics.
this
review,
we
aim
cover
basic
principles
experiments
nonspecialists,
fundamentals,
sample
preparation
process,
evolution
techniques
used,
data
analysis
strategies.
We
also
review
advances
research
last
5
lipidomics
glycomics,
adoption
three‐dimensional
multimodal
approaches,
implementation
artificial
intelligence/machine
learning
MSI‐based
studies.
clinical
single‐cell
is
discussed.
Spatially
resolved
on
other
small
molecule
metabolites
such
as
amino
acids,
polyamines,
nucleotides/nucleosides
will
not
be
discussed
context.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(8), P. 4366 - 4371
Published: Jan. 20, 2023
Innovative
methods
for
engineering
cancer
cell
membranes
promise
to
manipulate
cell–cell
interactions
and
boost
cell-based
therapeutics.
Here,
we
illustrate
an
in
situ
approach
selectively
modify
by
employing
enzyme-instructed
peptide
self-assembly
(EISA)
strategy.
Using
three
phosphopeptides
(pY1,
pY2,
pY3)
targeting
the
membrane-bound
epidermal
growth
factor
receptor
(EGFR)
differing
just
one
phosphorylated
tyrosine,
reveal
that
site-specific
phosphorylation
patterns
pY1,
pY3
can
distinctly
command
their
preorganization
levels,
self-assembling
kinetics,
spatial
distributions
of
resultant
assemblies
cellulo.
Overall,
pY1
is
most
capable
producing
preorganized
shows
fastest
dephosphorylation
reaction
presence
alkaline
phosphatase
(ALP),
as
well
highest
binding
affinity
EGFR
after
dephosphorylation.
Consequently,
exhibits
greatest
capacity
construct
stable
on
with
assistance
both
ALP
EGFR.
We
further
use
peptide–protein
peptide–peptide
co-assembly
strategies
apply
two
types
antigens,
namely
ovalbumin
(OVA)
protein
dinitrophenyl
(DNP)
hapten
respectively,
membranes.
This
study
demonstrates
a
very
useful
technique
construction
around
cells
implies
versatile
strategy
artificially
enrich
membrane
components
potential
immunotherapy.
Cellular and Molecular Immunology,
Journal Year:
2022,
Volume and Issue:
19(3), P. 432 - 444
Published: Jan. 5, 2022
Tumour
growth
and
dissemination
is
largely
dependent
on
nutrient
availability.
It
has
recently
emerged
that
the
tumour
microenvironment
rich
in
a
diverse
array
of
lipids
increase
abundance
with
progression
play
role
promoting
metastasis.
Here,
we
describe
pro-tumorigenic
roles
lipid
uptake,
metabolism
synthesis
detail
therapeutic
potential
targeting
cancer.
Additionally,
highlight
new
insights
into
distinct
immunosuppressive
effects
microenvironment.
Lipids
threaten
an
anti-tumour
environment
whereby
metabolic
adaptation
to
linked
immune
dysfunction.
Finally,
differential
commondietary
cancer
which
may
uncover
for
specific
dietary
regimens
association
traditional
therapies.
Understanding
relationship
between
lipids,
tumour,
cells
important
context
obesity
reveal
possibility
harness
diet
treatment
cancers.
