Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 2, 2024
Abstract
Research
into
mRNA
vaccines
is
advancing
rapidly,
with
proven
efficacy
against
coronavirus
disease
2019
and
promising
therapeutic
potential
a
variety
of
solid
tumors.
Adjuvants,
critical
components
vaccines,
significantly
enhance
vaccine
effectiveness
are
integral
to
numerous
formulations.
However,
the
development
selection
adjuvant
platforms
still
in
their
nascent
stages,
mechanisms
many
adjuvants
remain
poorly
understood.
Additionally,
immunostimulatory
capabilities
certain
novel
drug
delivery
systems
(DDS)
challenge
traditional
definition
adjuvants,
suggesting
that
revision
this
concept
necessary.
This
review
offers
comprehensive
exploration
applications
self-adjuvant
DDS.
It
thoroughly
addresses
existing
issues
mentioned
above
details
three
main
challenges
immune-related
adverse
event,
unclear
mechanisms,
unsatisfactory
outcomes
old
age
group
design
practical
application
cancer
adjuvants.
Ultimately,
proposes
optimization
strategies
which
consists
exploring
adjuvant,
optimizing
DDS,
improving
route
administration
improve
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(12), P. 8585 - 8597
Published: March 13, 2024
Adjuvant
treatment
after
surgical
resection
usually
plays
an
important
role
in
delaying
disease
recurrence.
Immunotherapy
displays
encouraging
results
increasing
patients'
chances
of
staying
cancer-free
surgery,
as
reported
by
recent
clinical
trials.
However,
the
outcomes
current
immunotherapy
need
to
be
improved
due
limited
responses,
patient
heterogeneity,
nontargeted
distribution,
and
immune-related
adverse
effects.
This
work
describes
a
programmable
hydrogel
adjuvant
for
personalized
resection.
By
filling
cavity,
this
system
aims
address
secretion
granzyme
B
(GrB)
during
improve
low
responses
typically
observed,
while
minimizing
side
The
TLR7/8
agonist
imidazoquinoline
(IMDQ)
is
linked
self-assembling
peptide
backbone
through
GrB-responsive
linkage.
Its
release
could
enhance
activation
function
immune
cells,
which
will
lead
increased
GrB
effectiveness
together.
recruits
initiates
dendritic
cell
maturation,
induces
M1
polarized
macrophages
reverse
immunosuppressive
tumor
microenvironment
situ.
In
multiple
murine
models,
suppresses
growth,
increases
animal
survival
long-term
immunological
memory,
protects
mice
against
rechallenge,
leading
effective
prophylactic
therapeutic
responses.
provides
potential
chemical
strategy
overcome
limitations
associated
with
immunotherapy.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(6)
Published: March 28, 2024
Abstract
Because
therapeutic
cancer
vaccines
can,
in
theory,
eliminate
tumor
cells
specifically
with
relatively
low
toxicity,
they
have
long
been
considered
for
application
repressing
progression.
Traditional
containing
a
single
or
few
discrete
epitopes
failed
the
clinic,
possibly
due
to
challenges
epitope
selection,
target
downregulation,
cell
heterogeneity,
microenvironment
immunosuppression,
lack
of
vaccine
immunogenicity.
Whole
membrane
vaccines,
which
provide
rich
source
antigens,
are
emerging
as
viable
alternatives.
Autologous
and
allogenic
cellular
evaluated
clinical
treatments.
Tumor
membranes
(TCMs)
an
intriguing
antigen
source,
membrane‐accessible
targets
and,
at
same
time,
serve
integrated
carriers
adjuvants
other
agents.
This
review
provides
summary
properties
technologies
TCM
vaccines.
Characteristics,
categories,
mechanisms,
preparation
methods
discussed,
demonstrable
additional
benefits
derived
from
combining
chemotherapy,
sonodynamic
therapy,
phototherapy,
oncolytic
viruses.
Further
research
chemistry,
biomedicine,
immunology,
bioinformatics
address
current
drawbacks
could
facilitate
adoption
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(10)
Published: March 6, 2024
Nanomaterials
offer
unique
opportunities
to
engineer
immunomodulatory
activity.
In
this
work,
we
report
the
Toll-like
receptor
agonist
activity
of
a
nanoscale
adjuvant
zeolitic
imidazolate
framework-8
(ZIF-8).
The
accumulation
ZIF-8
in
endosomes
and
pH-responsive
release
its
subunits
enable
selective
engagement
with
endosomal
receptors,
minimizing
risk
off-target
activation.
intrinsic
properties
ZIF-8,
along
efficient
delivery
biomimetic
presentation
severe
acute
respiratory
syndrome
coronavirus
2
spike
protein
receptor-binding
domain
trimer,
primed
rapid
humoral
cell-mediated
immunity
dose-sparing
manner.
Our
study
offers
insights
for
next-generation
adjuvants
that
can
potentially
impact
future
vaccine
development.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 2, 2024
Abstract
Research
into
mRNA
vaccines
is
advancing
rapidly,
with
proven
efficacy
against
coronavirus
disease
2019
and
promising
therapeutic
potential
a
variety
of
solid
tumors.
Adjuvants,
critical
components
vaccines,
significantly
enhance
vaccine
effectiveness
are
integral
to
numerous
formulations.
However,
the
development
selection
adjuvant
platforms
still
in
their
nascent
stages,
mechanisms
many
adjuvants
remain
poorly
understood.
Additionally,
immunostimulatory
capabilities
certain
novel
drug
delivery
systems
(DDS)
challenge
traditional
definition
adjuvants,
suggesting
that
revision
this
concept
necessary.
This
review
offers
comprehensive
exploration
applications
self-adjuvant
DDS.
It
thoroughly
addresses
existing
issues
mentioned
above
details
three
main
challenges
immune-related
adverse
event,
unclear
mechanisms,
unsatisfactory
outcomes
old
age
group
design
practical
application
cancer
adjuvants.
Ultimately,
proposes
optimization
strategies
which
consists
exploring
adjuvant,
optimizing
DDS,
improving
route
administration
improve
