npj Digital Medicine, Journal Year: 2025, Volume and Issue: 8(1)
Published: Feb. 2, 2025
Language: Английский
Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 182, P. 114098 - 114098
Published: Jan. 5, 2022
Language: Английский
Citations
131
Journal of Hypertension, Journal Year: 2023, Volume and Issue: 42(1), P. 23 - 49
Published: Sept. 12, 2023
Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic (DBP) at least 90 (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. is associated with increased risk cardiovascular disease (CVD) events (e.g. coronary heart disease, failure and stroke) death. An international panel experts convened by the International College Experts compiled lifestyle management recommendations first-line strategy to prevent control hypertension in adulthood. We also recommend that changes be continued even when pressure-lowering medications are prescribed. Specific based on literature evidence summarized advice start these measures early life, including maintaining a healthy body weight, levels different types physical activity, eating drinking, avoidance cessation smoking alcohol use, stress sleep levels. discuss relevance specific approaches consumption sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting well integrated strategies implement using, for example, behaviour change-related technologies digital tools.
Language: Английский
Citations
97
International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 633, P. 122628 - 122628
Published: Jan. 20, 2023
Three-dimensional (3D) printing is drastically redefining medicine production, offering digital precision and personalized design opportunities. One emerging 3D technology selective laser sintering (SLS), which garnering attention for its high precision, compatibility with a wide range of pharmaceutical materials, including low-solubility compounds. However, the full potential SLS medicines yet to be realized, requiring expertise considerable time-consuming resource-intensive trial-and-error research. Machine learning (ML), subset artificial intelligence, an in silico tool that accomplishing remarkable breakthroughs several sectors ability make highly accurate predictions. Therefore, present study harnessed ML predict printability formulations. Using dataset 170 formulations from 78 models were developed inputs included formulation composition characterization data retrieved Fourier-transformed infrared spectroscopy (FT-IR), X-ray powder diffraction (XRPD) differential scanning calorimetry (DSC). Multiple explored, supervised unsupervised approaches. The results revealed can achieve accuracies, by using leading maximum F1 score 81.9%. FT-IR, XRPD DSC as resulted 84.2%, 81.3%, 80.1%, respectively. A subsequent pipeline was built combine predictions into one consensus model, where found further increase 88.9%. it determined first time benefit multi-modal data, combining numeric, spectral, thermogram data. lays groundwork leveraging existing developing high-performing computational accelerate development.
Language: Английский
Citations
48
Health Policy, Journal Year: 2024, Volume and Issue: 146, P. 105122 - 105122
Published: July 2, 2024
Digital health technologies hold promises for reducing care costs, enhancing access to care, and addressing labor shortages. However, they risk exacerbating inequalities by disproportionately benefitting a subset of the population. Use digital accelerated during Covid-19 pandemic. Our scoping review aimed describe how related their use were conceptually assessed after pandemic understand strategies policies might support equity. We used PRISMA Extension reviews, identifying 2055 papers through an initial search 3 databases in 2021 complementary 2022, which 41 retained. Analysis was guided eHealth equity framework. Results showed that reported U.S. other high-income countries mainly differences according individual sociodemographic characteristics. Health disparities technology interaction between context implementation more rarely documented. Policy recommendations stressed adoption lens strategy development multilayered intersectoral collaboration align interventions with needs specific subgroups. Finally, findings suggested evaluations wellbeing distribution should inform policies.
Language: Английский
Citations
25
Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 72 - 72
Published: Jan. 9, 2025
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that significantly increases the risk of cardiovascular disease, which leading cause morbidity and mortality among diabetic patients. A central pathophysiological mechanism linking T2DM to complications oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production body’s antioxidant defenses. Hyperglycemia in promotes stress through various pathways, including formation advanced glycation end products, activation protein kinase C, mitochondrial dysfunction, polyol pathway. These processes enhance ROS generation, endothelial vascular inflammation, exacerbation damage. Additionally, disrupts nitric oxide signaling, impairing vasodilation promoting vasoconstriction, contributes complications. This review explores molecular mechanisms by pathogenesis disease T2DM. It also examines potential lifestyle modifications, such dietary changes physical activity, reducing mitigating risks this high-risk population. Understanding these critical for developing targeted therapeutic strategies improve outcomes
Language: Английский
Citations
7
Pharmaceutical Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 28, 2025
Language: Английский
Citations
3
JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(1), P. e2452976 - e2452976
Published: Jan. 3, 2025
Importance Digital health in biomedical research and its expanding list of potential clinical applications are rapidly evolving. A combination new digital technologies (DHTs), novel uses existing DHTs through artificial intelligence– machine learning–based algorithms, improved integration analysis data from multiple sources has enabled broader use delivery these tools for care purposes. The aim this study was to assess the growth overall trajectory DHT funding a National Institutes Health (NIH)–wide grant portfolio analysis. Observations This used 21 preselected search terms identify allocations across 9-year period between fiscal year 2015 2023. subset grants were manually curated confirm terms’ accuracy ascertain stage development, focus, types or approaches. To understand translation application, common measures, such as publications trials included. represented 2.8% (US $7 628 967 500) NIH funded increased during $348 725 600 $1 533 281 000. using same 3714 14 786 89 240, respectively. More development purposes (59.3%) than regulatory (41.0%) based on manual, second-level curation. Conclusions Relevance found that investments at over past 9 years increase been steady since 2015, including even after COVID-19 pandemic. Increased is expected continue become more integral part ecosystem.
Language: Английский
Citations
2
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 17, 2025
As China's "Internet + Health" initiative advances, the digital economy significantly influences quality of medical and health services. However, there is a research gap concerning economy's specific impacts, mechanisms, marginal effects on these This impedes comprehensive understanding potential in healthcare. study aims to clarify impact mechanisms services levels, offering scientific foundation for more targeted effective policy formulation, thereby fostering sustainable development Utilizing panel data from 31 provinces (2011-2020), this paper employs Spatial Durbin Model analyze spatial healthcare service levels. To ensure analysis accuracy robustness, refines weight matrix addresses model endogeneity using Generalized Two-Stage Least Squares method. Additionally, it examines regional disparities through SDM explores intermediary threshold mediation effect model. Findings indicate that positively affects both local neighboring regions, with variations across areas. The eastern region particularly benefits enhancement while central western regions see less impact. enhances by improving resource levels promoting their coordinated development. positive moderated region's economic pronounced impacts higher plays crucial role services, its full beneficial industry's advancement sustainability. Nonetheless, addressing uneven essential equitable all
Language: Английский
Citations
2
Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 181, P. 114076 - 114076
Published: Dec. 8, 2021
Language: Английский
Citations
103
Additive manufacturing, Journal Year: 2022, Volume and Issue: 52, P. 102673 - 102673
Published: Feb. 8, 2022
3D printing (3DP), or additive manufacturing, has been actively investigated as one of the enabling technologies for impending era personalized medicines. However, existing 3DP do not afford speeds required on-demand production medicines in fast-paced clinical settings. Volumetric is a novel technology that offers rapid speed and overcomes geometric surface quality limitations layer-based vat photopolymerization techniques. Unlike previous technologies, volumetric cures entire desired geometry simultaneously by exploiting threshold behavior process arise due to oxygen-induced polymerization inhibition. In this work, first time, printer was used fabricate drug-loaded printed tablets (Printlets™) within seconds. Six resin formulations were evaluated using printer, each composed poly(ethylene glycol) diacrylate (PEGDA) crosslinking monomer, lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) photoinitiator, paracetamol model drug. Water PEG300 included diluents varying concentrations facilitate drug release. Paracetamol-loaded Printlets successfully fabricated 17 s. Drug release rates could be tuned altering monomer-to-diluent ratio photosensitive resin, with lower releasing faster. The present work confirms suitability products matter Upon further optimization, can enable rapid, fabrication medical devices.
Language: Английский
Citations
64