Journal of the Optical Society of America A,
Journal Year:
2023,
Volume and Issue:
40(5), P. 955 - 955
Published: March 29, 2023
In
various
biomedical
optics
therapies,
knowledge
of
how
light
is
absorbed
or
scattered
by
tissues
crucial.
Currently,
it
suspected
that
a
low
compression
applied
to
the
skin
surface
may
improve
delivery
into
tissue.
However,
minimum
pressure
needed
be
significantly
increase
penetration
has
not
been
determined.
this
study,
we
used
optical
coherence
tomography
(OCT)
measure
attenuation
coefficient
human
forearm
dermis
in
regime
(<8kPa).
Our
results
show
pressures
such
as
4
kPa
8
are
sufficient
decreasing
at
least
1.0mm-1.
Biophysical Reviews,
Journal Year:
2022,
Volume and Issue:
14(4), P. 1005 - 1022
Published: Aug. 1, 2022
Optical
clearing
of
the
lung
tissue
aims
to
make
it
more
transparent
light
by
minimizing
scattering,
thus
allowing
reconstruction
three-dimensional
structure
with
a
much
better
resolution.
This
is
great
importance
for
monitoring
viral
infection
impact
on
alveolar
and
oxygen
transport.
agents
(OCAs)
can
provide
not
only
lesser
scattering
components
but
also
may
influence
molecular
transport
function
membrane.
Air-filled
lungs
present
significant
challenges
optical
imaging
including
coherence
tomography
(OCT),
confocal
two-photon
microscopy,
Raman
spectroscopy,
because
large
refractive-index
mismatch
between
alveoli
walls
enclosed
air-filled
region.
During
OCT
imaging,
strongly
backscattered
at
each
air–tissue
interface,
such
that
image
typically
limited
single
alveolus.
At
same
time,
filling
these
cavities
an
OCA,
which
water
(physiological
solution)
be
attributed
since
its
refractive
index
higher
than
air
will
lead
transmittance.
review
presents
general
principles
advances
in
field
(TOC)
technology,
OCA
delivery
mechanisms
tissue,
studies
microbial
infections
response,
antimicrobial
antiviral
photodynamic
therapies
using
methylene
blue
(MB)
indocyanine
green
(ICG)
dyes
as
photosensitizers.
Frontiers in Microbiology,
Journal Year:
2022,
Volume and Issue:
13
Published: July 12, 2022
Vibrio
vulnificus
is
an
invasive
marine
bacterium
that
causes
a
variety
of
serious
infectious
diseases.
With
the
increasing
multidrug-resistant
variants,
treatment
V.
infections
becoming
more
difficult.
In
this
study,
we
explored
antimicrobial
blue
light
(aBL;
405
nm
wavelength)
for
infections.
We
first
assessed
efficacy
aBL
against
five
strains
in
vitro.
Next,
identified
and
quantified
intracellular
porphyrins
to
provide
mechanistic
insights.
Additionally,
measured
reactive
oxygen
species
(ROS)
production
bacterial
membrane
permeabilization
following
exposures.
Lastly,
conducted
preclinical
study
investigate
safety
prevention
burn
caused
by
mice.
found
effectively
killed
vitro
both
planktonic
biofilm
states,
with
up
5.17-
4.57-log10
CFU
reduction
being
achieved,
respectively,
exposure
216
J/cm2.
Protoporphyrin
IX
coproporphyrins
were
predominant
all
strains.
ROS
was
significantly
increased
exposures
(P
<
0.01),
there
evidence
aBL-induced
0.0001).
studies,
female
mice
treated
30
min
after
inoculation
showed
survival
rate
81%
7
days
observation,
while
only
28%
observed
untreated
0.001).
At
6
h
post-inoculation,
86%
achieved
aBL-treated
=
0.0002).
For
male
mice,
86
63%
rates
when
given
inoculation,
compared
32%
0.0004
P
0.04).
did
not
reduce
cellular
proliferation
or
induce
apoptosis.
cytokines
upregulated
males
treatment,
including
MCSF
0.001),
MCP-5
TNF
RII
CXCL1
TIMP-1
0.05),
one
females
(TIMP-1;
suggesting
may
certain
inflammatory
processes.
conclusion,
potentially
be
applied
prevent
treat
Journal Of Advanced Zoology,
Journal Year:
2022,
Volume and Issue:
43(1), P. 104 - 110
Published: Aug. 10, 2022
This
study
was
conducted
to
find
out
the
effect
of
5
periods
exposure
laser
rays
(0,15,10,5,20)
minutes
on
phenotypic
mutations
Drosophila
melanogaster,
as
well
calculating
percentage
mortality
and
larval
failure.
The
results
showed
that
beams
had
significant
effects
in
causing
mutations,
especially
15-minute
period,
which
amounted
0.33
thus
formed
differences
compared
control
group.
also
caused
clear
rate
mortality,
death
100%
for
period
20
minutes,
while
this
decreased
27%
34%
10
respectively,
lowest
failure
0%
at
20,
led
all
larvae.
Journal of the Optical Society of America A,
Journal Year:
2023,
Volume and Issue:
40(5), P. 955 - 955
Published: March 29, 2023
In
various
biomedical
optics
therapies,
knowledge
of
how
light
is
absorbed
or
scattered
by
tissues
crucial.
Currently,
it
suspected
that
a
low
compression
applied
to
the
skin
surface
may
improve
delivery
into
tissue.
However,
minimum
pressure
needed
be
significantly
increase
penetration
has
not
been
determined.
this
study,
we
used
optical
coherence
tomography
(OCT)
measure
attenuation
coefficient
human
forearm
dermis
in
regime
(<8kPa).
Our
results
show
pressures
such
as
4
kPa
8
are
sufficient
decreasing
at
least
1.0mm-1.
