Lentinan: An unexplored novel biomaterial in drug and gene delivery applications DOI

Ankaj Kumar,

Rishi Paliwal, Arvind Gulbake

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 356, P. 316 - 336

Published: March 9, 2023

Language: Английский

Restore Intestinal Barrier Integrity: An Approach for Inflammatory Bowel Disease Therapy DOI Creative Commons
Kong Chen,

Meifeng Yang,

Ningning Yue

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 5389 - 5413

Published: Aug. 1, 2024

The intestinal barrier maintained by various types of columnar epithelial cells, plays a crucial role in regulating the interactions between contents (such as microbiota), immune system, and other components. Dysfunction mucosa is significant pathophysiological mechanism clinical manifestation inflammatory bowel disease (IBD). However, current therapies for IBD primarily focus on suppressing inflammation, no disease-modifying treatments specifically target barrier. Given side effects associated with chronic immunotherapy, effective alternative that promote mucosal healing are highly attractive. In this review, we examined function mechanisms behind its disruption IBD. We illustrated complex process proposed therapeutic approaches to strategies These included application stem cell transplantation organ-like tissue engineering generate new tissue. Finally, discussed potential restore treatment

Language: Английский

Citations

7
Chitosan and sodium alginate nanocarrier system: Controlling the release of rapeseed-derived peptides and improving their therapeutic efficiency of anti-diabetes DOI
Qianqian Wang, Xinran Dong, Erick Damián Castañeda-Reyes

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130713 - 130713

Published: March 11, 2024

Language: Английский

Citations

6
Ameliorative effect of buckwheat polysaccharides on colitis via regulation of the gut microbiota DOI

Jhih-Yi Yang,

Sheng-Yi Chen,

Yen‐Hsien Wu

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 227, P. 872 - 883

Published: Dec. 20, 2022

Language: Английский

Citations

26
Pulmonary endothelium-targeted nanoassembly of indomethacin and superoxide dismutase relieves lung inflammation DOI Creative Commons
Yi Yang, Makhloufi Zoulikha, Qingqing Xiao

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(11), P. 4607 - 4620

Published: May 26, 2023

Lung inflammation is an essential inducer of various diseases and closely related to pulmonary-endothelium dysfunction. Herein, we propose a pulmonary endothelium-targeted codelivery system anti-inflammatory indomethacin (IND) antioxidant superoxide dismutase (SOD) by assembling the biopharmaceutical SOD onto “vector” rod-like pure IND crystals, followed coating with anti-ICAM-1 antibody (Ab) for targeting endothelial cells. The has 237 nm diameter in length extremely high drug loading 39% 2.3% SOD. Pharmacokinetics biodistribution studies demonstrate extended blood circulation strong accumulation after intravenous injection lipopolysaccharide (LPS)-induced inflammatory murine model. Particularly, allows robust capacity target endothelium mostly due rod-shape Ab effect. In vitro, preparation shows synergistic effects LPS-activated vivo, exhibits superior pharmacodynamic efficacy revealed significantly downregulating inflammatory/oxidative stress markers, such as TNF-α, IL-6, COX-2, reactive oxygen species (ROS), lungs. conclusion, based on crystals could well effectively alleviate lung inflammation. study offers promising approach combat endothelium-associated diseases.

Language: Английский

Citations

15
Lentinan: An unexplored novel biomaterial in drug and gene delivery applications DOI

Ankaj Kumar,

Rishi Paliwal, Arvind Gulbake

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 356, P. 316 - 336

Published: March 9, 2023

Language: Английский

Citations

14