Protein-based nanoparticles for therapeutic nucleic acid delivery

Biomaterials, Journal Year: 2024, Volume and Issue: 305, P. 122464 - 122464

Published: Jan. 2, 2024

Language: Английский

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Harnessing Pyroptosis for Cancer Immunotherapy

Cells, Journal Year: 2024, Volume and Issue: 13(4), P. 346 - 346

Published: Feb. 16, 2024

Cancer immunotherapy is a novel pillar of cancer treatment that harnesses the immune system to fight tumors and generally results in robust antitumor immunity. Although has achieved remarkable clinical success for some patients, many patients do not respond, underscoring need develop new strategies promote Pyroptosis an immunostimulatory type regulated cell death activates innate system. A hallmark pyroptosis release intracellular contents such as cytokines, alarmins, chemokines can stimulate adaptive activation. Recent studies suggest promotes Here, we review mechanisms by which be induced highlight induce cells defense. We discuss how modulates tumor microenvironment immunity also research areas focus on continued development anticancer treatment. Pyroptosis-based therapies offer promising avenue treating immunologically 'cold' tumors.

Language: Английский

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Efferocytosis‐Inspired Biomimetic Nanoplatform for Targeted Acute Lung Injury Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)

Published: Feb. 2, 2024

Acute lung injury (ALI) is a serious inflammatory disease that causes impairment of pulmonary function. Phenotypic modulation macrophage in the using fibroblast growth factor 21 (FGF21) may be potential strategy to alleviate inflammation. Consequently, achieving specific delivery FGF21 inflamed and subsequent efficient internalization by macrophages within becomes critical for effective ALI treatment. Here, an apoptotic cell membrane-coated zirconium-based metal-organic framework UiO-66 reported precise (ACM@U-FGF21) whose design inspired process efferocytosis. ACM@U-FGF21 with signals recognized internalized phagocytes blood lung, then intracellular can inhibit excessive secretion pro-inflammatory cytokines these cells relieve Utilizing homologous targeting properties inherited from source spontaneous recruitment immune sites, accumulate preferentially after injection. The results prove effectively reduces damage modulating polarization suppressing activated cells. This study demonstrates usefulness efferocytosis-inspired treatment ALI.

Language: Английский

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Tuning Lipid Nanoparticles for RNA Delivery to Extrahepatic Organs

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract RNA therapeutics have been successfully transitioned into clinical applications. Lipid nanoparticles (LNPs) are widely employed as nonviral delivery vehicles for in commercial vaccine and gene therapy products. However, the bottleneck expanding applications of LNP‐based lies tendency these to preferentially accumulate liver. This challenge underscores need design LNPs capable delivering organs beyond In this perspective, recent progress is discussed developing strategies designing deliver extrahepatic organs. Organ‐selective targeting capability achieved by either altering composition LNP formulation or chemically modifying ionizable lipid component. Both approaches result changes physicochemical properties LNPs, which subsequently alters biomolecular corona that adsorbs onto its surface following administration. The a known mechanism mediates organ‐selective delivery. Furthermore, perspective aims provide an outlook on shaping next‐generation platforms. Potential efforts include specific cell types, improving safety profile overcome physiological barriers against organ‐specific

Language: Английский

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Unraveling the complex roles of macrophages in obese adipose tissue: an overview

Frontiers of Medicine, Journal Year: 2024, Volume and Issue: 18(2), P. 205 - 236

Published: Jan. 2, 2024

Language: Английский

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