Inhalable Metal–Organic Frameworks: A Promising Delivery Platform for Pulmonary Diseases Treatment

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Inhalation delivery, offering a direct pathway for administering drugs to the lungs in form of dry powders or aerosols, stands out as an optimal approach localized treatment pulmonary diseases. However, intricate anatomical architecture lung often poses challenges maintaining effective drug concentrations within over extended periods. This highlights pressing need develop rational inhalable delivery systems that can improve outcomes respiratory Metal-organic frameworks (MOFs) assembled from inorganic metal ions and organic ligands, characterized by customizable porous chemical composition, modifiable porosity, vast surface area, straightforward modification, adjustable biocompatibility, have garnered extensive attention biomedical sphere. The introduction MOFs into inhalation therapy represents promising avenue navigate past hurdles associated with traditional methods. Therefore, this review summarizes characteristics together latest advances, challenges, opportunities utilizing treating diseases discusses prospects field alongside potential pathways translating strategy clinic.

Language: Английский

---

State-of-the-Art Review on Inhalable Lipid and Polymer Nanocarriers: Design and Development Perspectives

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 347 - 347

Published: March 1, 2024

Nowadays, the interest in research towards local administration of drugs via inhalation route is growing as it enables direct targeting lung tissue, at same time reducing systemic side effects. This great significance era nucleic acid therapeutics and personalized medicine for treatment severe diseases. However, success any therapy driven by a delicate interplay factors, such physiochemical profile payload, formulation, device, aerodynamic properties, interaction with fluids. The development drug delivery systems tailored to needs this central its revolutionize respiratory With review, we aim provide an up-to-date overview advances nanoparticulate carriers special regard concerning lipid polymer-based nanocarriers (NCs). Starting from biological barriers that anatomical structure imposes, need be overcome, current strategies achieve efficient best support NCs are highlighted.

Language: Английский

---

A Novel Catalase Nanogels for Effective Treatment of Neutrophilic Asthma

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)

Published: April 2, 2024

Abstract Neutrophilic asthma, as corticosteroid resistant is clinically more severe than eosinophilic asthma. Therefore, the treatment of neutrophilic asthma has been a challenging. Reactive oxygen species (ROS) play key role in However, direct use antioxidant enzymes, such catalase (CAT), challenging due to poor stability, short plasma half‐life, and lack effective drug delivery systems pulmonary systems. In this work, novel kind nanogels for delivering CAT (CAT‐NGs) synthesized, incorporating with an antibacterial “protective film”, modality Compared free CAT, CAT‐NGs demonstrated superior enzyme activity trypsin resistance, exhibited outstanding anti‐inflammatory activities vitro. Furthermore, showed significant inhibitory effects on nontypeable Haemophilus influenzae (NTHi), Staphylococcus aureus ( S. ) Escherichia coli E. ). Additionally, nebulized inhalation alleviated inflammation mice. Mechanistically, alleviation symptoms by possibly associated clearance ROS lung inhibition NLRP3 NF‐κB pathways. Hence, work have therapeutic potential CAT‐NGs, offering new insights into clinical

Language: Английский

---

Efferocytosis‐Inspired Biomimetic Nanoplatform for Targeted Acute Lung Injury Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)

Published: Feb. 2, 2024

Acute lung injury (ALI) is a serious inflammatory disease that causes impairment of pulmonary function. Phenotypic modulation macrophage in the using fibroblast growth factor 21 (FGF21) may be potential strategy to alleviate inflammation. Consequently, achieving specific delivery FGF21 inflamed and subsequent efficient internalization by macrophages within becomes critical for effective ALI treatment. Here, an apoptotic cell membrane-coated zirconium-based metal-organic framework UiO-66 reported precise (ACM@U-FGF21) whose design inspired process efferocytosis. ACM@U-FGF21 with signals recognized internalized phagocytes blood lung, then intracellular can inhibit excessive secretion pro-inflammatory cytokines these cells relieve Utilizing homologous targeting properties inherited from source spontaneous recruitment immune sites, accumulate preferentially after injection. The results prove effectively reduces damage modulating polarization suppressing activated cells. This study demonstrates usefulness efferocytosis-inspired treatment ALI.

Language: Английский

---

Pulmonary drug delivery devices and nanosystems as potential treatment strategies for acute respiratory distress syndrome (ARDS)

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 657, P. 124182 - 124182

Published: April 30, 2024

Language: Английский

---

Inhalable biomimetic nanomotor for pulmonary thrombus therapy

Nano Today, Journal Year: 2024, Volume and Issue: 55, P. 102171 - 102171

Published: Jan. 30, 2024

Language: Английский

---

Realveolarization with inhalable mucus-penetrating lipid nanoparticles for the treatment of pulmonary fibrosis in mice

Science Advances, Journal Year: 2024, Volume and Issue: 10(24)

Published: June 12, 2024

The stemness loss-associated dysregeneration of impaired alveolar type 2 epithelial (AT2) cells abolishes the reversible therapy idiopathic pulmonary fibrosis (IPF). We here report an inhalable mucus-penetrating lipid nanoparticle (LNP) for codelivering dual mRNAs, promoting realveolarization via restoring AT2 IPF treatment. Inhalable LNPs were first formulated with dipalmitoylphosphatidylcholine and our in-house-made ionizable lipids high-efficiency mucus penetration codelivery messenger RNAs (mRNAs), encoding cytochrome b5 reductase 3 bone morphogenetic protein 4, respectively. After being inhaled in a bleomycin model, reverses mitochondrial dysfunction through ameliorating nicotinamide adenine dinucleotide biosynthesis, which inhibits accelerated senescence cells. Concurrently, pathological remodeling fibroblast activation induced by are terminated, ultimately prompting regeneration. Our data demonstrated that mRNA-LNP system exhibited high expression lung cells, markedly extricated collapse prolonged survival mice, providing clinically viable strategy against IPF.

Language: Английский

---

Phospholipids of inhaled liposomes determine the in vivo fate and therapeutic effects of salvianolic acid B on idiopathic pulmonary fibrosis

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 1 - 15

Published: May 21, 2024

Language: Английский

---

Dry powder inhalers of antitubercular drugs

Tuberculosis, Journal Year: 2022, Volume and Issue: 135, P. 102228 - 102228

Published: June 24, 2022

Language: Английский

---

Open pocket and tighten holes: Inhalable lung cancer-targeted nanocomposite for enhanced ferroptosis-apoptosis synergetic therapy

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 458, P. 141487 - 141487

Published: Jan. 18, 2023

Language: Английский

---