Chitosan-capped silver nanoparticles with potent and selective intrinsic activity against the breast cancer cells DOI Creative Commons
Ahmed A. H. Abdellatif, Ahmed Abdelfattah, Mahmoud A. Younis

et al.

Nanotechnology Reviews, Journal Year: 2023, Volume and Issue: 12(1)

Published: Jan. 1, 2023

Graphical abstract

Language: Английский

Impact of physicochemical properties on biological effects of lipid nanoparticles: Are they completely safe DOI

Ziyi Yuan,

Ruyu Yan,

Zuyi Fu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172240 - 172240

Published: April 4, 2024

Language: Английский

Citations

9
Research Advances of Lipid Nanoparticles in the Treatment of Colorectal Cancer DOI Creative Commons
Junyi Zhang, Kamran Ali, Jianwei Wang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 6693 - 6715

Published: July 1, 2024

Colorectal cancer (CRC) is a common type of gastrointestinal tract (GIT) and poses an enormous threat to human health. Current strategies for metastatic colorectal (mCRC) therapy primarily focus on chemotherapy, targeted therapy, immunotherapy, radiotherapy; however, their adverse reactions drug resistance limit clinical application. Advances in nanotechnology have rendered lipid nanoparticles (LNPs) promising nanomaterial-based delivery system CRC therapy. LNPs can adapt the biological characteristics by modifying formulation, enabling selective drugs tissues. They overcome limitations traditional therapies, such as poor water solubility, nonspecific biodistribution, limited bioavailability. Herein, we review composition targeting Subsequently, applications these treatment including delivery, thermal nucleic acid-based gene are summarized with examples provided. The last section provides glimpse into advantages, current limitations, prospects CRC.

Language: Английский

Citations

9
Self-homing nanocarriers for mRNA delivery to the activated hepatic stellate cells in liver fibrosis DOI Creative Commons
Mahmoud A. Younis, Yusuke Sato, Yaser Hosny Ali Elewa

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 353, P. 685 - 698

Published: Dec. 15, 2022

Language: Английский

Citations

33
Bioinspired Lipid Nanocarriers for RNA Delivery DOI Creative Commons
Alex Golubovic,

Shannon J. Tsai,

Bowen Li

et al.

ACS Bio & Med Chem Au, Journal Year: 2023, Volume and Issue: 3(2), P. 114 - 136

Published: Jan. 16, 2023

RNA therapy is a disruptive technology comprising rapidly expanding category of drugs. Further translation therapies to the clinic will improve treatment many diseases and help enable personalized medicine. However, in vivo delivery remains challenging due lack appropriate tools. Current state-of-the-art carriers such as ionizable lipid nanoparticles still face significant challenges, including frequent localization clearance-associated organs limited (1–2%) endosomal escape. Thus, vehicles must be improved further unlock full potential therapeutics. An emerging strategy modify existing or new nanocarriers by incorporating bioinspired design principles. This method generally aims tissue targeting, cellular uptake, escape, addressing some critical issues facing field. In this review, we introduce different strategies for creating lipid-based discuss implications each based on reported findings. These include naturally derived lipids into mimicking bioderived molecules, viruses, exosomes. We evaluate factors required succeed. Finally, point areas research that should furthered more successful rational delivery.

Language: Английский

Citations

21
Chitosan-capped silver nanoparticles with potent and selective intrinsic activity against the breast cancer cells DOI Creative Commons
Ahmed A. H. Abdellatif, Ahmed Abdelfattah, Mahmoud A. Younis

et al.

Nanotechnology Reviews, Journal Year: 2023, Volume and Issue: 12(1)

Published: Jan. 1, 2023

Graphical abstract

Language: Английский

Citations

20