ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(13), P. 15446 - 15458
Published: June 26, 2024
In
recent
years,
the
application
of
hollow
mesoporous
silicon
nanoparticles
in
biomedical
field
has
attracted
much
attention
because
their
excellent
features.
this
study,
sonosensitizer
curcumin
(Cur),
chemotherapy
drug
doxorubicin
(Dox),
and
perfluoropropane
(C3F8)
gas
were
loaded
into
a
multifunctional
silica
nanoparticle
(MHMSN).
The
surface
MHMSN
was
modified
with
biotin
molecule
acid-sensitive
groups
(cis-aconitic
anhydride-polyethylene
glycol,
CDM-PEG).
as-prepared
(CDF-MHMSN)
demonstrates
improved
therapeutic
efficacy
enhanced
tumor
contrast
ultrasound
performance.
Surface-modified
CDM-PEG
can
improve
blood
circulation
ability
peel
off
acidic
microenvironment,
which
enhance
endocytosis
cancer
cells.
As
sonosensitizer,
Cur
could
generate
reactive
oxygen
species
(ROS)
under
stimulation
to
kill
cells
reduce
multidrug
resistance
Dox
by
inhibiting
expression
P-glycoprotein.
Overall,
CDF-MHMSN
exhibits
good
biocompatibility,
imaging
capability,
effective
antitumor
ability,
may
contribute
improving
treatment
strategy
for
hepatocellular
carcinoma.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
177, P. 116925 - 116925
Published: June 15, 2024
Macrophages
are
central
to
the
immune
system
and
found
in
nearly
all
tissues.
Recently,
development
of
therapies
based
on
macrophages
has
attracted
significant
interest.
These
utilize
macrophages'
key
roles
immunity,
their
ability
navigate
biological
barriers,
tendency
accumulate
tumors.
This
review
explores
advancement
macrophage-based
treatments.
We
discuss
bioengineering
for
improved
anti-tumor
effects,
use
CAR
macrophage
therapy
targeting
cancer
cells,
as
vehicles
therapeutic
delivery.
Additionally,
we
examine
engineered
products,
like
extracellular
vesicles
membrane-coated
nanoparticles,
potential
precise
less
toxic
tumor
therapy.
Challenges
moving
these
from
research
clinical
practice
also
highlighted.
The
aim
is
succinctly
summarize
current
status,
challenges,
future
directions
Small,
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 13, 2023
Abstract
Endometrial
cancer
is
the
most
common
gynecological
malignancy
worldwide
and
unfortunately
has
a
much
higher
mortality
rate
in
Black
women
compared
with
White
women.
Many
potential
factors
contribute
to
these
rates,
including
underlying
effects
of
systemic
interpersonal
racism.
Furthermore,
other
trends
medicine
have
links
rates
participation
clinical
trials,
hormone
therapy,
pre‐existing
health
conditions.
Addressing
high
incidence
disparate
endometrial
requires
novel
methods,
such
as
nanoparticle‐based
therapeutics.
These
therapeutics
been
growing
increasing
prevalence
pre‐clinical
development
far‐reaching
implications
therapy.
The
rigor
studies
enhanced
by
likeness
model
human
body.
In
systems
for
3D
cell
culture,
example,
extracellular
matrix
mimics
tumor
more
closely.
emphasis
on
precision
can
be
applied
using
methods
models
patient‐derived
data.
This
review
highlights
intersections
nanomedicine,
medicine,
racial
disparities
within
provides
insights
into
reducing
recent
scientific
advances
nanoscale.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(13), P. 15446 - 15458
Published: June 26, 2024
In
recent
years,
the
application
of
hollow
mesoporous
silicon
nanoparticles
in
biomedical
field
has
attracted
much
attention
because
their
excellent
features.
this
study,
sonosensitizer
curcumin
(Cur),
chemotherapy
drug
doxorubicin
(Dox),
and
perfluoropropane
(C3F8)
gas
were
loaded
into
a
multifunctional
silica
nanoparticle
(MHMSN).
The
surface
MHMSN
was
modified
with
biotin
molecule
acid-sensitive
groups
(cis-aconitic
anhydride-polyethylene
glycol,
CDM-PEG).
as-prepared
(CDF-MHMSN)
demonstrates
improved
therapeutic
efficacy
enhanced
tumor
contrast
ultrasound
performance.
Surface-modified
CDM-PEG
can
improve
blood
circulation
ability
peel
off
acidic
microenvironment,
which
enhance
endocytosis
cancer
cells.
As
sonosensitizer,
Cur
could
generate
reactive
oxygen
species
(ROS)
under
stimulation
to
kill
cells
reduce
multidrug
resistance
Dox
by
inhibiting
expression
P-glycoprotein.
Overall,
CDF-MHMSN
exhibits
good
biocompatibility,
imaging
capability,
effective
antitumor
ability,
may
contribute
improving
treatment
strategy
for
hepatocellular
carcinoma.
