Nano Research, Journal Year: 2023, Volume and Issue: 17(2), P. 462 - 475
Published: July 1, 2023
Language: Английский
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 205, P. 115177 - 115177
Published: Jan. 5, 2024
Monitoring brain responses to ultrasonic interventions is becoming an important pillar of a growing number applications employing acoustic waves actuate and cure the brain. Optical interrogation living tissues provides unique means for retrieving functional molecular information related activity disease-specific biomarkers. The hybrid optoacoustic imaging methods have further enabled deep-tissue with optical contrast at high spatial temporal resolution. marriage between light sound thus brings together highly complementary advantages both modalities toward precision interrogation, stimulation, therapy strong impact in fields ultrasound neuromodulation, gene drug delivery, or noninvasive treatments neurological neurodegenerative disorders. In this review, we elaborate on current advances monitoring interventions. We describe main principles mechanisms underlying each method before diving into corresponding biomedical applications. identify areas improvement as well promising approaches clinical translation potential.
Language: Английский
Citations
5
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: July 25, 2024
Depression is a chronic mental disorder characterized by persistent low mood and loss of interest. Treatments for depression are varied but may not be sufficient cure. Drug-based treatment regimens have drawbacks such as slow onset action, bioavailability, drug side effects. Nanocarrier Drug Delivery Systems (NDDS) has received increasing attention brain delivery since it assists the through blood-brain barrier improves which beneficial treating depression. Due to particle size physicochemical properties nanocarriers, presents promise improve stability solubility antidepressants, thereby enhancing concentration. Moreover, ligand-modified nanocarriers can taken target direct medicines release system reduce The purpose present review provide an up-to-date understanding relevant antidepressants in different routes ingestion, lay foundation patients with
Language: Английский
Citations
5
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(44)
Published: Sept. 12, 2024
Abstract Improving clinical immunotherapy for glioblastoma (GBM) relies on addressing the immunosuppressive tumor microenvironment (TME). Enhancing CD8 + T cell infiltration and preventing its exhaustion holds promise effective GBM immunotherapy. Here, a low‐intensity focused ultrasound (LIFU)‐guided sequential delivery strategy is developed to enhance cells activity in region. The of CXC chemokine ligand 10 (CXCL10) recruit interleukin‐2 (IL‐2) reduce their termed an “open‐source throttling” strategy. Consequently, up 3.39‐fold are observed with LIFU‐guided CXCL10, IL‐2, anti‐programmed death 1 (aPD‐L1), compared free aPD‐L1 group. immune checkpoint inhibitors (ICIs) therapeutic efficacy substantially enhanced by reversed TME due expansion cells, resulting elimination tumor, prolonged survival time, long‐term memory establishment orthotopic mice. Overall, cytokine ICIs offers which may present promising brain‐tumor
Language: Английский
Citations
5
npj Parkinson s Disease, Journal Year: 2024, Volume and Issue: 10(1)
Published: Oct. 23, 2024
In this review, we summarize preclinical and clinical trials investigating innovative neuromodulatory approaches for Parkinson disease (PD) motor symptom management. We highlight the following technologies: temporal interference, nanoparticles drug delivery, blood-brain barrier opening, gene therapy, optogenetics, upconversion nanoparticles, magnetothermal magnetoelectric ultrasound-responsive designer receptors exclusively activated by drugs. These studies establish basis novel promising treatments PD symptoms.
Language: Английский
Citations
5
Nano Research, Journal Year: 2023, Volume and Issue: 17(2), P. 462 - 475
Published: July 1, 2023
Language: Английский
Citations
12