Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Aug. 14, 2024
Natural
biomaterials,
particularly
fibrous
proteins,
are
extensively
utilized
in
skin
tissue
engineering.
However,
their
application
is
impeded
by
batch-to-batch
variance,
limited
chemical
or
physical
versatility,
and
environmental
concerns.
Recent
advancements
gene
editing
fermentation
technology
have
catalyzed
the
emergence
of
recombinant
protein
which
gaining
traction
The
modular
highly
customizable
nature
synthesis
enables
precise
control
over
biomaterial
design,
facilitating
incorporation
multiple
functional
motifs.
Additionally,
allows
for
a
transition
from
animal-derived
sources
to
microbial
sources,
thereby
reducing
endotoxin
content
rendering
biomaterials
more
amenable
scalable
production
clinical
use.
In
this
review,
we
provide
an
overview
prevalent
(collagens,
elastin,
silk
proteins
chimeric
derivatives)
used
engineering
(STE)
compare
them
with
counterparts.
Furthermore,
discuss
applications
STE,
along
associated
challenges
future
prospects.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(13), P. 4988 - 4988
Published: June 25, 2023
Hydrogels
made
from
proteins
are
attractive
materials
for
diverse
medical
applications,
as
they
biocompatible,
biodegradable,
and
amenable
to
chemical
biological
modifications.
Recent
advances
in
protein
engineering,
synthetic
biology,
material
science
have
enabled
the
fine-tuning
of
sequences,
hydrogel
structures,
mechanical
properties,
allowing
a
broad
range
biomedical
applications
using
hydrogels.
This
article
reviews
recent
progresses
on
hydrogels
with
special
focus
those
microbially
produced
proteins.
We
discuss
different
formation
strategies
their
associated
properties.
also
review
various
categorized
by
origin
sequences.
Lastly,
current
challenges
future
opportunities
engineering
protein-based
discussed.
hope
this
will
inspire
new
ideas
innovation,
leading
advanced
desirable
properties
wide
applications.
Journal of Biomaterials Science Polymer Edition,
Journal Year:
2024,
Volume and Issue:
35(15), P. 2402 - 2445
Published: July 17, 2024
Protein-based
wound
dressings
have
garnered
increasing
interest
in
recent
years
owing
to
their
distinct
physical,
chemical,
and
biological
characteristics.
The
intricate
molecular
composition
of
proteins
gives
rise
unique
characteristics,
such
as
exceptional
biocompatibility,
biodegradability,
responsiveness,
which
contribute
the
promotion
healing.
Wound
healing
is
an
ongoing
process
influenced
by
multiple
causes,
it
consists
four
phases.
Various
treatments
been
developed
repair
different
types
skin
wounds,
thanks
advancements
medical
technology
recognition
diverse
nature
wounds.
This
review
has
literature
reviewed
within
last
3-5
years-the
progress
development
protein
fundamental
properties
ideal
dressing.
Herein,
strides
protein-based
state-of-the-art
dressing
emphasize
significant
challenges
summarize
future
perspectives
for
applications.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2449 - 2461
Published: March 14, 2024
Peptide-based
materials
are
diverse
candidates
for
self-assembly
into
modularly
designed
and
stimuli-responsive
nanostructures
with
precisely
tunable
compositions.
Here,
we
genetically
fused
computationally
coiled
coil-forming
peptides
to
the
N-
C-termini
of
compositionally
distinct
multistimuli-responsive
resilin-like
polypeptides
(RLPs)
various
lengths.
The
successful
expression
these
hybrid
in
bacterial
hosts
was
confirmed
through
techniques
such
as
gel
electrophoresis,
mass
spectrometry,
amino
acid
analysis.
Circular
dichroism
spectroscopy
ultraviolet–visible
turbidimetry
demonstrated
that
despite
fusion
disparate
structural
responsive
units,
coils
remained
stable
polypeptides,
sequence-encoded
differences
thermoresponsive
phase
separation
RLPs
were
preserved.
Cryogenic
transmission
electron
microscopy
coarse-grained
modeling
showed
after
thermal
annealing
solution,
adopted
a
closed
loop
conformation
assembled
nanofibrils
capable
further
hierarchically
organizing
cluster
structures
ribbon-like
mediated
by
self-association
tendency
RLPs.
Polymers for Advanced Technologies,
Journal Year:
2023,
Volume and Issue:
35(1)
Published: Oct. 10, 2023
Abstract
The
present
study
provides
an
overview
of
scientific
developments
made
in
the
last
decade
field
green
adsorbents
focusing
on
modifications
cellulose
and
starch
their
applications
such
as
drug
delivery,
wastewater
treatment,
ion
exchange.
For
this
purpose,
introduction
to
various
methods
modifying
is
first
given,
then
properties,
application,
future
priorities
are
also
discussed.
Methods
modification
under
homogeneous
heterogeneous
conditions
using
modifiers
with
different
properties
described.
Various
for
use
obtained
reviewed.
A
comparison
sorption
based
other
used
industry
has
been
carried
out.
Future
perspectives
highlighted.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(30)
Published: March 19, 2024
Abstract
The
unique
biophysical
and
biochemical
properties
of
intrinsically
disordered
proteins
(IDPs)
their
recombinant
derivatives,
protein
polymers
(IDPPs)
offer
opportunities
for
producing
multistimuli‐responsive
materials;
sequence‐encoded
disorder
tendency
phase
separation
facilitate
the
development
multifunctional
materials.
This
review
highlights
strategies
enhancing
structural
diversity
elastin‐like
polypeptides
(ELPs)
resilin‐like
(RLPs),
self‐assembled
structures
via
genetic
fusion
to
ordered
motifs
such
as
helical
or
beta
sheet
domains.
In
particular,
this
describes
approaches
that
harness
synergistic
interplay
between
order‐promoting
thermoresponsive
building
blocks
design
hybrid
biomaterials,
resulting
in
well‐structured,
stimuli‐responsive
supramolecular
materials
on
nanoscale.
