Colloid Journal, Journal Year: 2023, Volume and Issue: 85(5), P. 770 - 781
Published: Oct. 1, 2023
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117782 - 117782
Published: Jan. 5, 2025
Language: Английский
Citations
1
Journal of Science Advanced Materials and Devices, Journal Year: 2025, Volume and Issue: unknown, P. 100875 - 100875
Published: March 1, 2025
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151811 - 151811
Published: April 30, 2024
Language: Английский
Citations
6
Pharmacological Research, Journal Year: 2023, Volume and Issue: 198, P. 106989 - 106989
Published: Nov. 17, 2023
Lymph node metastasis (LNM) significantly impacts the prognosis of cancer patients. Despite significant advancements in diagnostic techniques and treatment modalities, clinical challenges continue to persist realm LNM. These include difficulties early diagnosis, limited efficacy, potential side effects injuries associated with treatment. Nanotheranostics, a field within nanotechnology, seamlessly integrates therapeutic functionalities. Its primary goal is provide precise effective disease diagnosis simultaneously. The development nanotheranostics for LNM offers promising solution stratified management patients promotes advancement personalized medicine. This review introduces mechanisms its Furthermore, it demonstrates advantages nanotheranostics, focuses on face application, provides an outlook future trends. We consider strategy improve effectiveness efficiency as well
Language: Английский
Citations
15
Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)
Published: June 22, 2024
Abstract In recent years, it has been recognized that mechanical forces play an important regulative role in living organisms and possess a direct impact on crucial cell functions, ranging from growth to maintenance of tissue homeostasis. Advancements mechanobiology have revealed the profound signals diverse cellular responses are type specific. Notably, numerous studies elucidated pivotal different cues as regulatory factors influencing various processes, including spreading, locomotion, differentiation, proliferation. Given these insights, is unsurprising cells regulated by physical intricately linked modulation nanoparticle uptake kinetics processing. This complex interplay underscores significance understanding microenvironment shaping behaviors and, consequently, how interact with process nanoparticles. Nevertheless, our knowledge localized affect internalization processing nanoparticles remains rather limited. A significant gap exists literature concerning systematic analysis might bias interactions between cells. Hence, aim this review provide comprehensive critical existing regarding influence complicated dynamics cell-nanoparticle interactions. By addressing gap, we would like contribute detailed
Language: Английский
Citations
5
Pharmacological Reports, Journal Year: 2023, Volume and Issue: 75(5), P. 1066 - 1095
Published: Sept. 5, 2023
Abstract Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by burning sensation eczematous lesions in diverse portions body. The treatment AD exclusively focused to limit itching, reduce inflammation, repair breached barrier skin. Several therapeutic agents for management have been reported are use clinics. However, topical has an unswerving challenge medical fraternity owing impaired skin function this condition. To surmount problems conventional drug delivery systems, numerous nanotechnology-based formulations emerging as alternative new modalities AD. Latter enhances bioavailability target disease site, improves permeation efficacy with reduced systemic off-target side effects, thus patient health promotes compliance. This review aims describe various pathophysiological events involved occurrence AD, current challenges treatment, evidence molecular markers its management, combinatorial options, intervention therapeutics. Graphical abstract
Language: Английский
Citations
11
Journal of Dispersion Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10
Published: Jan. 3, 2025
Dimethylcurcumin (DMC) is a derivative of curcumin. Studies have shown that DMC can enhance the degradation androgen receptors (AR), thereby inhibiting AR-related diseases. However, extremely poor water solubility and fast metabolism in vivo greatly limit its clinical applications. In present study, liposomes loaded with were prepared by an improved membrane hydration method. The formulation was modified to obtain DMC-liposomes particle size between 110 150 nm, moderate encapsulation efficiency, good freeze-drying stability. vitro release studies showed displayed sustained drug release. Cellular uptake cellular enhanced compared free DMC. Compared DMC, more toxic 22Rv1 HepG2 cells vitro. These results suggest are promising for anticancer delivery.
Language: Английский
Citations
0
ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 11, 2025
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 11, 2025
Through the PFOEP-SO3(−) + multidrug molecules constructed nanoparticle (NP) experiments and validated by molecular simulation docking experiments, we propose a interaction principle for inducing aggregation-induced locally excited emission (AILE) luminescence from fluorenone (FO)-based conjugated polymers (CPs). Based on this mechanism, NP built π–π stacking. The NPs demonstrate facile synthesis, robust stability, high drug-loading efficiency, enabling tumor-specific drug release in acidic lysosomal environments (pH 3.8–4.7) to minimize off-target toxicity. Concurrently, PFOEPA exhibit pH-dependent fluorescence enhancement: incorporation induces structural reorganization into "sandwich" configuration, amplifying with blue shift under neutral/alkaline conditions, while acidic-triggered protonation collapse disrupts NPs. Moreover, it can be used as an indicator monitoring release, is accompanied changes during process. This possesses multiple functions expected serve effective pH-responsive delivery system.
Language: Английский
Citations
0
Chemical Research in Toxicology, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
Nanoparticles, defined by their nanoscale dimensions and unique physicochemical properties, are widely utilized in healthcare, electronics, environmental sciences, consumer products. However, increasing evidence of potential embryotoxic effects during pregnancy underscores the need for a molecular-level understanding interactions embryonic development. Nanoparticles such as titanium dioxide, silver, cerium oxide, copper quantum dots can cross placental barrier interfere with crucial developmental processes. At molecular level, they disrupt signaling pathways like Wnt Hedgehog, induce oxidative stress inflammation, cause genotoxic effects, all critical sensitive phases, organogenesis. Furthermore, these nanoparticles interact directly cellular components, including DNA, proteins, lipids, impairing function viability. Innovative strategies to mitigate nanoparticle toxicity, surface modifications incorporation biocompatible coatings, discussed solutions reduce adverse interactions. Various laboratory animal models used investigate nanoparticle-induced embryotoxicity evaluated efficacy limitations, providing insights into applicability effects. This Account examines mechanisms which compromise development emphasizes importance designing safer minimize maternal-fetal exposure risks, particularly biomedical applications.
Language: Английский
Citations
0