Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(13), P. 4044 - 4053
Published: March 22, 2024
Fungal
keratitis
(FK)
is
an
infectious
eye
disease
that
poses
a
significant
risk
of
blindness.
However,
the
effectiveness
conventional
antifungal
drugs
limited
due
to
intrinsic
ocular
barrier
impedes
drug
absorption.
There
urgent
need
develop
new
therapeutic
strategies
effectively
combat
FK.
Herein,
we
synthesized
ultrasmall
positively
charged
carbon
dot
using
simple
stage-melting
method.
The
can
penetrate
corneal
by
opening
tight
junctions,
allowing
them
reach
lesion
site
and
kill
fungi.
results
both
in
vitro
vivo
demonstrated
it
exhibited
good
biocompatibility
activity,
significantly
improving
effect
mouse
model
Therefore,
this
biophilic
size
positive
dot,
characterized
its
ability
properties,
may
offer
valuable
insights
into
design
effective
nanomedicines.
ACS Infectious Diseases,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 3, 2025
The
emergence
of
azole
resistance
and
tolerance
in
pathogenic
fungi
has
emerged
as
a
significant
public
health
concern,
emphasizing
the
urgency
for
innovative
strategies
to
bolster
efficacy
azole-based
treatments.
Drug
repurposing
stands
promising
practical
avenue
advancing
antifungal
therapy,
with
potential
swift
clinical
translation.
This
review
offers
comprehensive
overview
synergistic
agents
uncovered
through
drug
strategies,
alongside
an
in-depth
exploration
mechanisms
by
which
these
augment
potency.
Drawing
from
mechanisms,
we
delineate
aimed
at
enhancing
effectiveness,
such
inhibiting
efflux
pumps
elevate
concentrations
within
fungal
cells,
intensifying
ergosterol
synthesis
inhibition,
mitigating
cell
azoles,
disrupting
biological
processes
extending
beyond
synthesis.
is
beneficial
development
potentiators,
it
meticulously
examines
instances
provides
nuanced
discussions
on
underlying
progression
potentiators
strategies.
Journal of Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Candida
albicans
infection
is
a
major
public
health
problem,
exacerbated
by
the
emergence
of
drug-resistant
fungi
with
widespread
use
antifungal
drugs.
Therefore,
development
novel
drugs
for
C.
infections
crucial.
We
constructed
series
dendritic
peptides
(AFPs)
different
chain
lengths
fatty
acids
as
hydrophobic
ends
and
2
or
3
protease-stable
repeats
(Arg-Pro)
peptide
branches.
Among
them,
C4-3RP
exhibited
excellent
antidrug-resistant
fungal
biofilm
activity
(GMall
=
5.04
μM)
was
nontoxic.
Furthermore,
demonstrated
high
protease
stability
salt
ion
tolerance,
making
it
highly
effective
in
murine
skin
mediated
albicans.
In
addition,
uses
multiple
mechanisms
action
to
achieve
effects.
conclusion,
construction
holds
substantial
potential
treatment
provides
broader
perspective
on
design
peptide-based
Nucleic Acids Research,
Journal Year:
2024,
Volume and Issue:
53(D1), P. D1372 - D1382
Published: Sept. 13, 2024
Abstract
The
escalating
costs
and
high
failure
rates
have
decelerated
the
pace
of
drug
development,
which
amplifies
research
interests
in
developing
combinatorial/repurposed
drugs
understanding
off-target
adverse
reaction
(ADR).
In
other
words,
it
is
demanded
to
delineate
molecular
atlas
pharma-information
for
interactions.
However,
such
invaluable
data
were
inadequately
covered
by
existing
databases.
this
study,
a
major
update
was
thus
conducted
DrugMAP,
accumulated
(a)
20831
combinatorial
their
interacting
involving
1583
pharmacologically
important
molecules;
(b)
842
repurposed
with
795
(c)
3260
off-targets
relevant
ADRs
2731
(d)
various
types
pharmaceutical
information,
including
diverse
ADMET
properties,
versatile
diseases,
ADRs/off-targets.
With
growing
demands
discovering
therapies
rapidly
emerging
interest
AI-based
discovery,
DrugMAP
highly
expected
act
as
an
indispensable
supplement
databases
facilitating
accessible
at:
https://idrblab.org/drugmap/.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 9, 2025
Fungal
infections
pose
a
significant
global
public
health
threat,
particularly
candidemia
and
biofilm
formation.
Current
antifungal
drugs
have
limitations
due
to
their
toxicity
drug
resistance.
Ion
interference
therapy,
cuproptosis,
shows
potential
for
disease
treatment.
Herein,
nano
copper-chelate
Cu(DDC)2@BSA
(CDB)
is
synthesized
research
the
mechanism
of
cuproptosis-like
death
investigated.
Initially,
CDB
demonstrates
strong
inhibitory
effect
on
multiple
fungi
exhibits
activity
against
two
fluconazole-resistant
clinical
isolates.
The
decrease
in
ATPase
mitochondrial
membrane
indicates
that
may
involve
dysfunction.
Subsequently,
transcriptome
analysis
reveals
alterations
genes
related
copper
ions
transport
regulation,
oxidative
phosphorylation,
function.
Additionally,
overload
observed,
along
with
an
increase
heat
shock
protein
70
levels
lipoic
acid
synthetase
expression.
Given
biofilms
hinder
penetration,
quaternary
ammonium
chitosan
microneedles
are
employed
combination
penetrate
barrier
enhance
effect.
Overall,
this
study
provides
new
insight
into
presents
promising
strategy
fungal
infection
treatment
through
microneedle
delivery
system.
Journal of Fungi,
Journal Year:
2025,
Volume and Issue:
11(3), P. 236 - 236
Published: March 19, 2025
Biofilms
are
structurally
organized
communities
of
microorganisms
that
adhere
to
a
variety
surfaces.
These
produce
protective
matrices
consisting
polymeric
polysaccharides,
proteins,
nucleic
acids,
and/or
lipids
promote
shared
resistance
various
environmental
threats,
including
chemical,
antibiotic,
and
immune
insults.
While
algal
bacterial
biofilms
more
apparent
in
the
scientific
zeitgeist,
many
fungal
pathogens
also
form
biofilms.
surprisingly
common
morphologically
distinct
from
multicellular
molds
mushrooms
normally
associated
with
fungi
instead
an
assemblage
single-celled
organisms.
As
collection
yeast
filamentous
cells
cloaked
extracellular
matrix,
extreme
threat
public
health,
especially
conjunction
surgical
implants.
The
encapsulated
yeast,
Cryptococcus
neoformans,
is
opportunistic
pathogen
causes
both
pulmonary
disseminated
infections,
particularly
immunocompromised
individuals.
However,
there
emerging
trend
cryptococcosis
among
otherwise
healthy
C.
neoformans
forms
diverse
environments,
within
human
hosts.
Notably,
biofilm
association
correlates
increased
expression
multiple
virulence
factors
host
defenses
antifungal
treatments.
Thus,
it
crucial
develop
novel
strategies
combat
In
this
review,
we
discuss
development
treatment
biofilms,
particular
focus
on
neoformans.
