Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(7), P. 1845 - 1845
Published: July 20, 2023
Dental
implantation
is
currently
the
optimal
solution
for
tooth
loss.
However,
health
and
stability
of
dental
implants
have
emerged
as
global
public
concerns.
implant
placement,
healing
surgical
site,
osseointegration,
bone
tissues,
prevention
peri-implant
diseases
are
challenges
faced
in
achieving
long-term
implants.
These
been
ongoing
concerns
field
oral
implantation.
Probiotics,
beneficial
microorganisms,
play
a
significant
role
body
by
inhibiting
pathogens,
promoting
tissue
homeostasis,
facilitating
regeneration,
modulating
immune-inflammatory
levels.
This
review
explores
potential
probiotics
addressing
post-implantation
challenges.
We
summarize
existing
research
regarding
importance
managing
advocate
further
into
their
applications.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(18), P. 6687 - 6687
Published: Sept. 18, 2023
Nanotechnology
has
ushered
in
a
new
era
of
medical
innovation,
offering
unique
solutions
to
longstanding
healthcare
challenges.
Among
nanomaterials,
copper
and
oxide
nanoparticles
stand
out
as
promising
candidates
for
multitude
applications.
This
article
aims
provide
contemporary
insights
into
the
perspectives
challenges
regarding
use
medicine.
It
summarises
biomedical
potential
copper-based
nanoformulations,
including
progress
early-stage
research,
evaluate
mitigate
toxicity
nanomaterials.
The
discussion
covers
prospects
nanomaterials
context
their
successful
clinical
translation.
also
addresses
safety
concerns,
emphasizing
need
assessments
nanomedicines.
However,
attention
is
needed
solve
current
such
biocompatibility
controlled
release.
Ongoing
research
collaborative
efforts
overcome
these
obstacles
are
discussed.
analysis
guidance
safe
effective
integration
practice,
thereby
advancing
recent
literature
highlighted
multifaceted
associated
with
translation
from
laboratory
clinic.
In
particular,
remains
formidable
hurdle,
requiring
innovative
ensure
seamless
human
body.
Additionally,
achieving
release
therapeutic
agents
poses
complex
challenge
that
requires
meticulous
engineering
precise
design.
Small,
Journal Year:
2024,
Volume and Issue:
20(23)
Published: Jan. 8, 2024
Abstract
Foreign
body
reaction
(FBR)
is
a
prevalent
yet
often
overlooked
pathological
phenomenon,
particularly
within
the
field
of
biomedical
implantation.
The
presence
FBR
poses
heavy
burden
on
both
medical
and
socioeconomic
systems.
This
review
seeks
to
elucidate
protein
“fingerprint”
implant
materials,
which
generated
by
physiochemical
properties
materials
themselves.
In
this
review,
activity
macrophages,
formation
foreign
giant
cells
(FBGCs),
development
fibrosis
capsules
in
context
are
introduced.
Additionally,
relationship
between
various
elucidated
detail,
as
an
overview
existing
approaches
technologies
employed
alleviate
FBR.
Finally,
significance
components
(metallic
non‐metallic
materials),
surface
CHEMISTRY
(charge
wettability),
physical
characteristics
(topography,
roughness,
stiffness)
establishing
also
well
documented.
conclusion,
aims
emphasize
importance
provides
current
perspectives
developing
with
anti‐FBR
properties.
Results in Chemistry,
Journal Year:
2023,
Volume and Issue:
6, P. 101136 - 101136
Published: Sept. 22, 2023
In
modern
medicine,
implants
have
become
a
prevalent
solution
for
replacing
or
supporting
damaged
body
parts
across
various
specialties,
from
orthopedics
to
dentistry.However,
implant
failure
remains
significant
concern
despite
surgical
and
technology
improvements.
This
in-depth
review
aims
give
an
overview
of
materials
used
in
implants,
the
synthesis
process
dental
its
causes,
related
clinical
implications.
The
explores
failures,
including
biological
shortcomings
(infection
soft
tissue
complications)
reasons.
addition,
it
outlinesdifferent
treatment
options
dealing
with
failure.
It
also
discusses
difficulties
that
healthcare
professionals
face
managing
failed
implants.The
comes
close
by
emphasizing
need
more
investigation
into
underlying
causes
creation
preventative
measures.
highlights
value
interdisciplinary
cooperation
between
clinicians,
engineers,
researchers
raise
patient's
quality
life
increase
success
rates.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(23)
Published: Feb. 13, 2024
Abstract
Modulating
cellular
functions
at
the
dental
implant‐tissue
interface
to
augment
integration
and
prevent
bacterial
ingress
is
crucial
for
achieving
early
stability
long‐term
implant
success.
Nano‐engineering
strategies,
such
as
anodized
titanium
implants
with
titania
(TiO
2
)
nanotubes/nanopores,
are
emerging
a
promising
surface
modification
approach
enhance
infection.
Achieving
on‐demand
therapy
through
electrical
stimulation
(EST,
supply
of
voltage/current
local
tissue)
may
be
advantageous
but
has
not
been
explored
implants.
Further,
TiO
nanotubes/nanopores
represent
semi‐conducting
that
can
impede
EST
effectiveness.
In
this
pioneering
study,
nanopores
converted
into
conducting
Ti
perform
achieve
superior
soft‐tissue
antibacterial
efficacy.
In‐depth
characterizations
followed
by
assays
investigating
effect
on
cultured
human
salivary
biofilm
gingival
fibroblasts.
Significant
bactericidal
efficacy
demonstrated
(1.5
V
5
min
per
day)
using
nanopores.
enhanced
fibroblast
proliferation
collagen
secretion.
summary,
applied
nanoporous
promotes
healing
proposed
next‐generation
in
dentistry
therapy.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(13), P. 3061 - 3061
Published: June 27, 2024
Rehabilitation
of
fully
or
partially
edentulous
patients
with
dental
implants
represents
one
the
most
frequently
used
surgical
procedures.
The
work
Branemark,
who
observed
that
a
piece
titanium
embedded
in
rabbit
bone
became
firmly
attached
and
difficult
to
remove,
introduced
concept
osseointegration
revolutionized
modern
dentistry.
Since
then,
an
ever-growing
need
for
improved
implant
materials
towards
enhanced
material-tissue
integration
has
emerged.
There
is
strong
belief
nanoscale
will
produce
superior
generation
high
efficiency,
low
cost,
volume.
aim
this
review
explore
contribution
nanomaterials
implantology.
A
variety
have
been
proposed
as
potential
candidates
surface
customization.
They
can
inherent
antibacterial
properties,
provide
conditions
osseointegration,
act
reservoirs
biomolecules
drugs.
Titania
nanotubes
alone
combination
biological
agents
drugs
are
tissue
implants.
Regarding
immunomodulation
order
avoid
rejection,
titania
nanotubes,
graphene,
biopolymers
successfully
utilized,
sometimes
loaded
anti-inflammatory
extracellular
vesicles.
Peri-implantitis
prevention
be
achieved
through
properties
metal
nanoparticles
chitosan
hybrid
coatings
bearing
antibiotic
substances.
For
corrosion
resistance
various
explored.
However,
even
though
these
modifications
shown
promising
results,
future
research
necessary
assess
their
clinical
behavior
humans
proceed
widespread
commercialization.
ACS Applied Materials & Interfaces,
Journal Year:
2025,
Volume and Issue:
17(6), P. 8886 - 8900
Published: Jan. 31, 2025
The
controllable
regulation
of
immune
and
osteogenic
processes
plays
a
critical
role
in
the
modification
biocompatible
materials
for
tissue
regeneration.
In
this
study,
titanium
dioxide-europium
coatings
(MAO/Eu)
were
prepared
on
surface
alloy
(Ti-6Al-4V)
via
one-step
process
combining
microarc
oxidation
(MAO)
situ
doping.
incorporation
Eu
significantly
improved
hydrophilic
mechanical
properties
TiO2
without
altering
their
morphology.
presence
effectively
stimulated
calcium
influx
macrophages
activated
β-catenin
through
wnt/β-catenin
signaling
pathway.
Consequently,
macrophage
M2
polarization
was
accelerated
overexpression
prostaglandin
E2
(PGE2).
Additionally,
Ca2+
promoted
differentiation
MC3T3-E1
cells
synergistic
upregulation
transcription
factors
(e.g.,
AP-1,
BMP-2).
vivo
studies
demonstrated
that
MAO/Eu
enhanced
osseointegration
compared
with
group.
Therefore,
shows
promising
potential
as
an
ideal
coating
implants
offers
effective
immunomodulatory
strategies
improves
bone
integration.
Acta Biomaterialia,
Journal Year:
2023,
Volume and Issue:
170, P. 15 - 38
Published: Aug. 9, 2023
Surface
modification
of
implants
in
the
nanoscale
or
implant
nano-engineering
has
been
recognized
as
a
strategy
for
augmenting
bioactivity
and
achieving
long-term
success.
Characterizing
optimizing
characteristics
is
crucial
to
achieve
desirable
effects
post-implantation.
Modified
enables
tailored,
guided
accelerated
tissue
integration;
however,
our
understanding
limited
multicellular
(bulk)
interactions.
Finding
forces
experienced
by
single
cell
on
nano-engineered
will
aid
predicting
implants'
via
precise
quantification
adhesive
between
modified
surface
engineering
next
generation
bioactive
implants.
Atomic
force
microscope
(AFM)
unique
tool
that
characterization
interactions
biological
tissues,
aiding
implant-tissue
bioactivity.
The
topography
using
AFM
gauge
(topographical,
mechanical,
chemical,
electrical
magnetic)
(adhesion
cells)
presented.
A
special
focus
review
discuss
use
single-cell
spectroscopy
(SCFS)
employing
investigate
minute
involved
with
adhesion
(resident
bacterium)
Finally,
research
gaps
future
perspectives
relating
AFM-characterized
current
emerging
are
discussed
towards
performances.
This
highlights
advanced
AFM-based
surfaces
profiling
(investigating
topography)
probing
(using
probe
study
surface).
Nano-engineering
platform
augment
their
favourable
treatment
outcomes.
In
this
extensive
review,
we
closely
examine
Force
Microscopy
characterize
properties
(topography,
magnetic).
Next,
Single-Cell
Spectroscopy
encompassing
cell's
interaction
surface.
interdisciplinary
appeal
researchers
from
broader
scientific
community
interested
provide
an
improved
Dental Materials,
Journal Year:
2023,
Volume and Issue:
40(1), P. e1 - e17
Published: Oct. 25, 2023
Zirconia-based
dental
restorations
and
implants
are
gaining
attention
due
to
their
bioactivity,
corrosion
resistance
mechanical
stability.
Further,
surface
modification
of
zirconia
has
been
performed
at
the
macro-,
micro-
nanoscale
augment
bioactivity.
While
zirconia's
physical
chemical
characteristics
have
documented,
its
relation
performance
still
needs
be
explored.
This
extensive
review
aims
address
this
knowledge
gap.
critically
compares
contrasts
findings
from
articles
published
in
domain
'mechanical
stability
zirconia\
dentistry'
based
on
a
literature
survey
(Web
Science,
Medline/PubMed
Scopus
databases)
relevant
publications
international
peer-reviewed
journals.
Reviewing
data,
properties
zirconia,
such
as
fracture
resistance,
stress/tension,
flexural
strength,
fatigue,
wear
detailed
discussed
understand
biomechanical
compatibility
with
modified
dentistry
also
A
comprehensive
insight
into
critical
fundamental
is
presented.
research
challenges
future
directions
recommended.
extends
existing
it
they
can
modulated
design
next
generation
withstand
long-term
constant
loading.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(30)
Published: Feb. 22, 2024
Abstract
Bioinspired
titanium
implant
nanotexturing
achieved
via
advanced
techniques
such
as
lithography,
hydrothermal
and
laser
patterning
enables
modulation
of
cell
functions
toward
enhanced
bioactivity
antibacterial
efficacy.
However,
costly,
multi‐step
methods
limit
clinical
translation
benchtop
modification.
For
the
first
time,
single‐step,
cost‐effective,
translatable
electrochemical
anodization
is
reported
to
fabricate
bioinspired
nanopillar‐like
textures
on
micro‐rough
titanium.
In‐depth
surface
characterization
confirms
formation
novel
nanostructures,
namely
nanoscale
Spinules
,
Daggers
Papillae
Spikes
Flames
exhibiting
varied
roughness
wettability.
Next,
in
separate
experiments,
primary
human
osteoblasts
polymicrobial
salivary
biofilm
are
cultured
substrates.
Nanotextured
surfaces
show
high
protein
adhesion
maintain
proliferation,
adhesion,
spreading
osteoblasts.
Interestingly,
all
nanotextures
exhibit
superior
antibiofilm
abilities
compared
control
surfaces.
Bioactive
nano‐texturing
single‐step
has
potential
for
next
generation
orthopedic
dental
