Recent trends on polycaprolactone as sustainable polymer-based drug delivery system in the treatment of cancer: Biomedical applications and nanomedicine

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 666, P. 124734 - 124734

Published: Sept. 28, 2024

Language: Английский

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Skin Structure, Physiology, and Pathology in Topical and Transdermal Drug Delivery

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1403 - 1403

Published: Oct. 31, 2024

Several industries are increasingly focused on enhancing the delivery of active ingredients through skin to optimize therapeutic outcomes. By facilitating penetration barrier, these enhancers can significantly improve efficacy various formulations, ranging from skincare products agents targeting systemic circulation. As understanding physiology and mechanisms drug absorption deepen, adopting permeation more widely, ultimately leading better patient outcomes expanded treatment options. However, structure physiological function vary according different factors, such as area body between individuals. These variations, along with external environmental exposures, aging pathological conditions, introduce complexities that must be carefully considered when designing effective systems. Considering intricacies physiology, tailoring systems account for regional differences, individual variability, changes induced by factors or disease is critical optimizing This review discusses features structure, pathologies, well application in contexts. Furthermore, it addresses use animal models transdermal dermatological studies, latest developments this field.

Language: Английский

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Microneedle array patches for sustained delivery of fluphenazine: A micron scale approach for the management of schizophrenia

Biomaterials Advances, Journal Year: 2023, Volume and Issue: 153, P. 213526 - 213526

Published: June 16, 2023

Schizophrenia is a severe chronic mental illness characterised by impaired emotional and cognitive functioning. To treat this condition, antipsychotics are available in limited dosage forms, mainly oral injectable formulations. Although were designed to enhance adherence, they invasive, painful require healthcare professional be administered. overcome such administration issues, extensive research has been focused on developing transdermal antipsychotic In work, three microneedle (MN) systems developed deliver fluphenazine (FLU) systemically. A decanoic prodrug of FLU called decanoate (FLUD) was used two the MN formulations due its high lipophilicity. FLU-D loaded into dissolving MNs nanoemulsion (NE)-loaded MNs. The parent drug poly(lactic-co-glycolic acid) (PLGA)-tipped All evaluated vitro vivo. vivo evaluation showed their ability systemic circulation, as Cmax 36.11 ± 12.37 ng/ml. However, NE 12.92 6.3 ng/ml for FLU-PLGA tipped 21.57 2.45 Compared an intramuscular (IM) injection sesame oil, relative bioavailabilities 26.96 %, 21.73 % 42.45 MNs, respectively. plasma levels maintained above minimum human therapeutic limits week. Consequently, these various considered viable options delivery prodrug. offer patients user-friendly, painless, convenient long-acting method FLU. Reducing dosing frequency using less invasive methods can adherence foster positive outcomes. This study demonstrates capability adaptability technology transport hydrophobic molecules from skin circulation.

Language: Английский

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Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 4270 - 4292

Published: July 1, 2024

Bone, a fundamental constituent of the human body, is vital scaffold for support, protection, and locomotion, underscoring its pivotal role in maintaining skeletal integrity overall functionality. However, factors such as trauma, disease, or aging can compromise bone structure, necessitating effective strategies regeneration. Traditional approaches often lack biomimetic environments conducive to efficient tissue repair. Nanofibrous microspheres (NFMS) present promising platform regeneration by mimicking native extracellular matrix architecture. Through optimized fabrication techniques incorporation active biomolecular components, NFMS precisely replicate nanostructure biochemical cues essential osteogenesis promotion. Furthermore, exhibit versatile properties, including tunable morphology, mechanical strength, controlled release kinetics, augmenting their suitability tailored engineering applications. enhance cell recruitment, attachment, proliferation, while promoting osteogenic differentiation mineralization, thereby accelerating healing. This review highlights engineering, elucidating design principles key attributes. By examining recent preclinical applications, we assess current clinical status discuss critical considerations potential translation. offers crucial insights researchers at intersection biomaterials highlighting developments this expanding field.

Language: Английский

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Scaffolds of Chitosan-metallic hybrids as antimicrobial wound dressing

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 126541 - 126541

Published: Nov. 1, 2024

Language: Английский

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