Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(9)
Published: Jan. 30, 2024
Abstract
Cancer
immunotherapy,
a
field
within
immunology
that
aims
to
enhance
the
host's
anti‐cancer
immune
response,
frequently
encounters
challenges
associated
with
suboptimal
response
rates.
The
presence
of
myeloid‐derived
suppressor
cells
(MDSCs),
crucial
constituents
tumor
microenvironment
(TME),
exacerbates
this
issue
by
fostering
immunosuppression
and
impeding
T
cell
differentiation
maturation.
Consequently,
targeting
MDSCs
has
emerged
as
for
immunotherapy
aimed
at
enhancing
anti‐tumor
responses.
development
nanomedicines
specifically
designed
target
improve
effectiveness
transforming
immunosuppressive
tumors
into
ones
more
responsive
intervention.
This
review
provides
detailed
overview
in
TME
current
strategies
these
cells.
Also
benefits
nanoparticle‐assisted
drug
delivery
systems,
including
design
flexibility,
efficient
loading,
protection
against
enzymatic
degradation,
are
highlighted.
It
summarizes
advances
nanomedicine
MDSCs,
covering
enhanced
treatment
efficacy,
safety,
modulation
TME,
laying
groundwork
potent
cancer
immunotherapy.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 10283 - 10305
Published: Oct. 1, 2024
Abstract:
Niosomes
are
key
nanocarriers
composed
of
bilayer
vesicles
formed
by
non-ionic
surfactants
and
cholesterol,
offering
advantages
such
as
high
physicochemical
stability,
biodegradability,
cost-effectiveness,
low
toxicity.
This
review
discusses
their
significant
role
in
drug
delivery,
including
applications
anticancer
therapy
vaccine
delivery.
It
also
highlights
the
impact
on
niosome
formation,
delivery
pathways,
protein
corona
formation—a
relatively
underexplored
topic.
Furthermore,
application
artificial
intelligence
optimizing
design
functionality
is
examined.
Future
research
directions
include
enhancing
formulation
techniques,
expanding
scopes,
integrating
advanced
technologies.
provides
comprehensive
insights
practical
guidance
for
advancing
niosome-based
systems.
Keywords:
niosomes,
surfactant,
systems,
functionalization
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
26(1), P. 189 - 189
Published: Dec. 29, 2024
Extracellular
vesicles
(EVs)
are
a
heterogeneous
group
of
membrane-encapsulated
released
by
cells
into
the
extracellular
space.
They
play
crucial
role
in
intercellular
communication
transporting
bioactive
molecules
such
as
proteins,
lipids,
and
nucleic
acids.
EVs
can
be
detected
body
fluids,
including
blood
plasma,
urine,
saliva,
amniotic
fluid,
breast
milk,
pleural
ascites.
The
complexity
diversity
require
robust
standardized
approach.
By
adhering
to
protocols
guidelines,
researchers
ensure
consistency,
purity,
reproducibility
isolated
EVs,
facilitating
their
use
diagnostics,
therapies,
research.
Exosomes
microvesicles
represent
an
exciting
frontier
modern
medicine,
with
significant
potential
transform
diagnosis
treatment
various
diseases
important
personalized
medicine
precision
therapy.
primary
objective
this
review
is
provide
updated
analysis
significance
highlighting
mechanisms
action
exploring
applications
diseases.
Additionally,
addresses
existing
limitations
future
offering
practical
recommendations
resolve
current
challenges
enhance
viability
for
clinical
use.
This
comprehensive
approach
aims
bridge
gap
between
EV
research
its
application
healthcare.
