Targeted nanoparticle delivery unleashes synergistic photothermal and immunotherapeutic effects against hepatocellular carcinoma DOI Creative Commons
Amal Babu,

Padmanaban Sathiyamoorthy,

Sahil Chahal

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 19, 2024

The substantial mortality and morbidity of hepatocellular carcinoma, representing 90% liver cancers, poses a significant health burden. effectiveness traditional carcinoma treatments such as surgical resection, radiotherapy, chemotherapy is limited, underscoring the need for innovative therapeutic strategies. To this end, we synthesized phthalyl-pullulan nanoparticles encapsulating IR780 (an NIR-responsive heptamethine cyanine dye) R848 (resiquimod; TLR7/8 agonist) (PIR NPs). Characterization confirmed size loading capacity PIR NPs, controlled release therefrom upon NIR irradiation, thereby establishing potential versatile tool. NPs were readily taken up by Hepa 1-6 cells in vitro targeting asialoglycoprotein receptors present on its cellular surface. In vivo experiments combining photothermal therapy immunotherapy, following local near-infrared accumulated tumor sites induced immunogenic cell death activated tumor-specific T-cell immune response, thus highlighting their potent antitumor efficacy. combined efficacy immunotherapy presents promising avenue addressing shortcomings interventions. This study contributes valuable insights into development more effective targeted approaches treatment.

Language: Английский

Chitosan-based hydrogels: A comprehensive review of transdermal drug delivery DOI
Dahlang Tahir,

Ardiansyah Ardiansyah,

Heryanto Heryanto

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 298, P. 140010 - 140010

Published: Jan. 17, 2025

Language: Английский

Citations

4
Advances in hyaluronic acid: Bioactivity, complexed biomaterials and biological application: A review DOI Creative Commons
Huijun Ye, Ruijuan Zhang, Chunye Zhang

et al.

Asian Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Hyaluronic acid (HA) is a natural glycosaminoglycan found in the human body, particularly extracellular matrix of body fluids and tissues. It plays critical role cellular processes living organisms by maintaining tissue hydration, cell proliferation, differentiation, inflammatory response. HA exhibits significant biological activity skin care, aesthetic anti-aging, medical orthopedic repair, gynecological cancer monitoring, other pathological conditions. Due to its exceptional biocompatibility, biodegradability, lack toxicity, non-immunogenicity, capacity bond with substances, various HA-based biomedical products like hydrogels, microneedles, microspheres have been developed. These innovations also applied health fields, such as bone regeneration, gels for fillers, gynecology-related treatment, utilizing drug delivery pathway. The interest increasing due their functions. Therefore, this review aimed summarize properties focus on applications engineering healthcare, has some practical complexes materials, aesthetics, gynecology. Through review, we seek offer theoretical research assistance development bioproducts healthcare domain provide innovative insights health.

Language: Английский

Citations

8
Recent Advances in Liposomes Efficacy as a Drug Delivery Platform for Melanoma Treatment DOI
Elham Zarenezhad,

Zahra Kazeminejad,

Mahsa Rostami Chijan

et al.

Russian Journal of Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 51(1), P. 93 - 116

Published: Feb. 1, 2025

Language: Английский

Citations

1
Mulberry-inspired tri-act hydrogel for visual monitoring and enhanced diabetic wound repair DOI Creative Commons
Zhenhe Zhang, Bobin Mi, Yuheng Liao

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159313 - 159313

Published: Jan. 1, 2025

Language: Английский

Citations

0
Challenges and considerations in liposomal hydrogels for the treatment of infection DOI Creative Commons
Željka Vanić, May Wenche Jøraholmen, Nataša Škalko‐Basnet

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Jan. 10, 2025

Liposomal hydrogels are novel drug delivery systems that comprise preformed liposomes incorporated in destined for mostly localized therapy, herewith antimicrobial therapy. The formulation benefits from versatility of as lipid-based nanocarriers enable various antimicrobials different lipophilicities, and secondary vehicle, hydrogel, assures better retention time at the infection site. Especially an era alarming resistance, efficient therapy avoids systemic exposure related side effects is crucial. We provide overview liposomal were developed superior infections sites, with focus on skin vaginal infections. review summarizes challenges site most common infection-causing pathogens offers commentary relevant features needs to optimize increase outcome. discuss impact composition, size, choice polymer-forming hydrogel outcome based literature own experience field. offer improved By fine-tuning well properties, formulations performance can be optimized targeting specific

Language: Английский

Citations

0
Liposomes and niosomes approaches for wound healing DOI
Sandra Aparecida de Assis,

Sara Lima Alves

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 161 - 185

Published: Jan. 1, 2025

Language: Английский

Citations

0
Advanced Disease Therapeutics Using Engineered Living Drug Delivery Systems DOI
Narsimha Mamidi,

Fátima Franco De Silva,

Amin Orash Mahmoud Salehi

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Biological barriers significantly impede the delivery of nanotherapeutics to diseased tissues, diminishing therapeutic efficacy across pathologies such as cancer and inflammatory disorders. Although conventional strategies integrate multifunctional designs molecular components into nanomaterials (NMs), many approaches remain insufficient overcome these barriers. Key challenges, including inadequate drug accumulation at target sites nonspecific biodistribution, persist in nanotherapeutic development. NMs, which harness ability precisely modulate spatiotemporally control release kinetics, represent a transformative platform for targeted therapy. In this review, we highlight biological obstacles limiting effective treatment evaluate how stimuli-responsive NMs address constraints. By leveraging exogenous endogenous stimuli, improve specificity, reduce off-target effects, amplify activity within pathological microenvironments. We systematically analyze rational design synthesis driven by advances oncology, biomaterials science, nanoscale engineering. Furthermore, NM classes-including polymeric, lipid-based, inorganic, hybrid systems explore functionalization using targeting ligands, antibodies, biomimetic coatings. Diverse are evaluated, small-molecule prodrug activation, peptide- protein-based targeting, nucleic acid payloads, engineered cell-mediated transport. Despite promise challenges biocompatibility, scalable fabrication, clinical translation must be addressed. elucidating structure-function relationships refining stimulus-triggered mechanisms, pave way precision oncology strategies, enabling patient-specific therapies with enhanced safety. This interdisciplinary insights aims catalyze innovation next-generation nanomedicine treatment.

Language: Английский

Citations

0
Self-Healing Hydrogels with Intrinsic Antioxidant and Antibacterial Properties Based on Oxidized Hydroxybutanoyl Glycan and Quaternized Carboxymethyl Chitosan for pH-Responsive Drug Delivery DOI Creative Commons
Jaepil Jeong, Kyung‐Ho Kim, Eun Kyoung Oh

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 169 - 169

Published: Feb. 26, 2025

In this study, self-healing hydrogels were created using oxidized hydroxybutanoyl glycan (OHbG) and quaternized carboxymethyl chitosan (QCMCS), displaying antioxidant antibacterial properties for pH-responsive drug delivery. The structures of the modified polysaccharides confirmed through 1H NMR analysis. Double crosslinking in hydrogel occurred via imine bonds (between aldehyde group OHbG amine QCMCS) ionic interactions carboxyl QCMCS). exhibited improved thermal stability with an increase concentration. OHbG/QCMCS demonstrated high compressive strength, significant swelling, large pore size. Drug release profiles varied between pH 2.0 (96.57%) 7.4 (63.22%). Additionally, displayed effects without compromising polysaccharides’ inherent characteristics. No cytotoxicity was observed any samples. These findings indicate that is a biocompatible stimuli-responsive carrier, potential various pharmaceutical, biomedical, biotechnological applications.

Language: Английский

Citations

0
Advanced therapeutic strategies using Thermo-sensitive chitosan/pectin hydrogel in the treatment of multiple cancers DOI
Tosha Pandya,

Disha Joshi,

Zenab Presswala

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123454 - 123454

Published: Feb. 27, 2025

Language: Английский

Citations

0
Advantages and therapeutic applications of different semisolids as vehicles for nano-based systems DOI
Eman Samy Shalaby, S. I. Shalaby, Shaymaa A. Ismail

et al.

Therapeutic Delivery, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: March 21, 2025

The aim of this review is to highlight the role semisolid systems as vehicles for nanovesicles and nanoparticles. In general, nanotechnology plays a critical in facilitating delivery therapeutic agents their active sites, several nanocarrier have been explored topical administration components. major disadvantage prepared nanosystems low viscosity, which reduces time needed enough absorption negatively affects stability bioavailability. overcome limitation. conclusion, presents an updated summary recent advances use semisolids various through comprehensive scrutiny types advantages enhancing nanoparticles nanovesicles.

Language: Английский

Citations

0