Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Dec. 19, 2024
The
substantial
mortality
and
morbidity
of
hepatocellular
carcinoma,
representing
90%
liver
cancers,
poses
a
significant
health
burden.
effectiveness
traditional
carcinoma
treatments
such
as
surgical
resection,
radiotherapy,
chemotherapy
is
limited,
underscoring
the
need
for
innovative
therapeutic
strategies.
To
this
end,
we
synthesized
phthalyl-pullulan
nanoparticles
encapsulating
IR780
(an
NIR-responsive
heptamethine
cyanine
dye)
R848
(resiquimod;
TLR7/8
agonist)
(PIR
NPs).
Characterization
confirmed
size
loading
capacity
PIR
NPs,
controlled
release
therefrom
upon
NIR
irradiation,
thereby
establishing
potential
versatile
tool.
NPs
were
readily
taken
up
by
Hepa
1-6
cells
in
vitro
targeting
asialoglycoprotein
receptors
present
on
its
cellular
surface.
In
vivo
experiments
combining
photothermal
therapy
immunotherapy,
following
local
near-infrared
accumulated
tumor
sites
induced
immunogenic
cell
death
activated
tumor-specific
T-cell
immune
response,
thus
highlighting
their
potent
antitumor
efficacy.
combined
efficacy
immunotherapy
presents
promising
avenue
addressing
shortcomings
interventions.
This
study
contributes
valuable
insights
into
development
more
effective
targeted
approaches
treatment.
Liquid Crystals and their Application,
Journal Year:
2023,
Volume and Issue:
23(4), P. 38 - 48
Published: Dec. 26, 2023
Lyotropic
liquid
crystalline
systems
are
of
great
interest
as
carriers
biological
substances
for
targeted
delivery,
mainly
transdermal
administration
drugs
and
their
application
to
the
skin
mucous
membranes.
The
wetting
adhesive
interactions
lyomesophases
gel
based
on
a
chitosan
polysaccharide
in
lactic
acid
solution
glass
substrate
(base
surface)
surface
semi-permeable
polytetrafluoroethylene
membrane
(model
epidermis
horny
layer)
were
studied.
effect
riboflavin
drug
(vitamin
B2)
tension
studied
samples
amount
adhesion
work
has
been
established.
It
is
shown
that
biocompatible
chitosan-containing
can
be
used
various
biomedical
purposes,
including
delivery.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Dec. 19, 2024
The
substantial
mortality
and
morbidity
of
hepatocellular
carcinoma,
representing
90%
liver
cancers,
poses
a
significant
health
burden.
effectiveness
traditional
carcinoma
treatments
such
as
surgical
resection,
radiotherapy,
chemotherapy
is
limited,
underscoring
the
need
for
innovative
therapeutic
strategies.
To
this
end,
we
synthesized
phthalyl-pullulan
nanoparticles
encapsulating
IR780
(an
NIR-responsive
heptamethine
cyanine
dye)
R848
(resiquimod;
TLR7/8
agonist)
(PIR
NPs).
Characterization
confirmed
size
loading
capacity
PIR
NPs,
controlled
release
therefrom
upon
NIR
irradiation,
thereby
establishing
potential
versatile
tool.
NPs
were
readily
taken
up
by
Hepa
1-6
cells
in
vitro
targeting
asialoglycoprotein
receptors
present
on
its
cellular
surface.
In
vivo
experiments
combining
photothermal
therapy
immunotherapy,
following
local
near-infrared
accumulated
tumor
sites
induced
immunogenic
cell
death
activated
tumor-specific
T-cell
immune
response,
thus
highlighting
their
potent
antitumor
efficacy.
combined
efficacy
immunotherapy
presents
promising
avenue
addressing
shortcomings
interventions.
This
study
contributes
valuable
insights
into
development
more
effective
targeted
approaches
treatment.
