Spermatozoon-propelled microcellular submarines combining innate magnetic hyperthermia with derived nanotherapies for thrombolysis and ischemia mitigation DOI Creative Commons

Pei-Wei Weng,

Chia‐Hung Liu,

Pei-Ru Jheng

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 8, 2024

Abstract Thrombotic cardiovascular diseases are a prevalent factor contributing to both physical impairment and mortality. Thrombolysis ischemic mitigation have emerged as leading contemporary therapeutic approaches for addressing the consequences of injury reperfusion damage. Herein, an innovative cellular-cloaked spermatozoon-driven microcellular submarine (SPCS), comprised multimodal motifs, was designed integrate nano-assembly thrombolytics with immunomodulatory ability derived from innate magnetic hyperthermia. Rheotaxis-based navigation utilized home cross clot barrier, finally accumulate in vascular organs, where thrombolytic motif “switched-on” by action thrombus red blood cell-driven In murine model, SPCS system combining hyperthermia demonstrated capacity augment delivery efficacy, produce nanotherapeutic outcomes, exhibit potent activity, ameliorate tissue These findings underscore multifaceted potential our approach, offering ischemia-mitigating effects. Given its extended effects thrombus-targeting capability, this biocompatible holds promise agent enhancing efficacy preventing risks after managing thrombosis. Graphical abstract

Language: Английский

Spermatozoon-propelled microcellular submarines combining innate magnetic hyperthermia with derived nanotherapies for thrombolysis and ischemia mitigation DOI Creative Commons

Pei-Wei Weng,

Chia‐Hung Liu,

Pei-Ru Jheng

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 8, 2024

Abstract Thrombotic cardiovascular diseases are a prevalent factor contributing to both physical impairment and mortality. Thrombolysis ischemic mitigation have emerged as leading contemporary therapeutic approaches for addressing the consequences of injury reperfusion damage. Herein, an innovative cellular-cloaked spermatozoon-driven microcellular submarine (SPCS), comprised multimodal motifs, was designed integrate nano-assembly thrombolytics with immunomodulatory ability derived from innate magnetic hyperthermia. Rheotaxis-based navigation utilized home cross clot barrier, finally accumulate in vascular organs, where thrombolytic motif “switched-on” by action thrombus red blood cell-driven In murine model, SPCS system combining hyperthermia demonstrated capacity augment delivery efficacy, produce nanotherapeutic outcomes, exhibit potent activity, ameliorate tissue These findings underscore multifaceted potential our approach, offering ischemia-mitigating effects. Given its extended effects thrombus-targeting capability, this biocompatible holds promise agent enhancing efficacy preventing risks after managing thrombosis. Graphical abstract

Language: Английский

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