NIR-II Fluorescent Probes for Fluorescence-Imaging-Guided Tumor Surgery

Biosensors, Journal Year: 2024, Volume and Issue: 14(6), P. 282 - 282

Published: May 30, 2024

Second near-infrared (NIR-II) fluorescence imaging is the most advanced fidelity method with extraordinary penetration depth, signal-to-background ratio, biocompatibility, and targeting ability. It currently booming in medical realm to diagnose tumors being widely applied for fluorescence-imaging-guided tumor surgery. To efficiently execute this modern modality, scientists have designed various probes capable of showing NIR-II window. Here, we update state-of-the-art fluorescent recent literature, including indocyanine green, emissive cyanine dyes, BODIPY probes, aggregation-induced emission fluorophores, conjugated polymers, donor-acceptor-donor carbon nanotubes, quantum dots imaging-guided Furthermore, point out that new materials NIR-III higher wavelength range further optimize results are a challenge scientific world. In general, hope review will serve as handbook researchers students who an interest developing applying surgery it expedite clinical translation from bench bedside.

Language: Английский

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Scaffolds of Chitosan-metallic hybrids as antimicrobial wound dressing

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 126541 - 126541

Published: Nov. 1, 2024

Language: Английский

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Nanofibrous Chitin Clusters Constructed via Controllable Crystalline Structure Transition for 3D Functional Materials

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract Intensively studied polymeric particle production technologies often rely on the combination of polymer self‐assembly and processing techniques. Herein, an elegant crystallization transition‐mediated strategy is proposed to confine molecular within a limited range, avoiding need for extra steps. This approach enables regenerated nanofibrous chitin clusters woven with helical nanofibers. By dissolving β ‐chitin in aqueous NaOH solution adjusting degree deacetylation (DD value) 28.0–41.4%, chains pathway facilitated undergo crystalline transition from α hydrated chitosan. diminishes tendency confines submicro‐ micrometer scales. The morphological parameters these clusters, including cluster size, nanofiber tentacle density, diameter, pitch, can be tuned by DD value. These are successfully employed as building blocks create 3D structural materials thermal insulation functional food applications, demonstrating their potential constructing advanced materials. It anticipated that structure concept applied other fabrication, opening up new avenue designing particles various applications.

Language: Английский

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Multifunctional targeted nanosystem based on aggregation-induced emission: enhanced synergistic mild-photothermal chemotherapy of prostate cancer via downregulation of heat shock protein 70 under NIR-II imaging

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 252, P. 114667 - 114667

Published: April 2, 2025

Language: Английский

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Deciphering Convection Enhanced Delivery: A Paradigm Shift for Circumventing Glioblastoma Multiforme

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106398 - 106398

Published: Nov. 1, 2024

Language: Английский

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Fluorescence Lifetime Imaging for Quantification of Targeted Drug Delivery in Varying Tumor Microenvironments

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Abstract Trastuzumab (TZM) is a monoclonal antibody that targets the human epidermal growth factor receptor 2 (HER2) and clinically used for treatment of HER2‐positive breast tumors. However, tumor microenvironment can limit access TZM to HER2 across whole thereby compromising TZM's therapeutic efficacy. An imaging methodology non‐invasively quantify binding TZM‐HER2, which required action, distribution within tumors with varying microenvironments much needed. Near‐infrared (NIR) fluorescence lifetime (FLI) Forster Resonance Energy Transfer (FRET) performed measure TZM‐HER2 binding, using in vitro microscopy vivo widefield macroscopy, overexpressing ovarian cancer cells xenografts, respectively. Immunohistochemistry validate results. NIR FLI FRET data show variations intracellular bound AU565 tumor‐passaged XTM cell lines comparison SKOV‐3 cells. Macroscopy (MFLI) display reduced compared tumors, as validated by ex immunohistochemistry. Moreover, AU565/XTM xenografts different amounts distributions TME components, such collagen vascularity. Therefore, these results suggest are refractory delivery due their disrupted vasculature increased content. The study demonstrates powerful analytical tool monitor antibodydrugs both cultures live systems. Especially, MFLI unique modality directly target engagement potential elucidate role drug efficacy intact xenografts.

Language: Английский

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Fluoride Hafnium/Zirconium-Softened Nanoprobes for Near-Infrared-IIb and CT Dual-Mode Bioimaging

Nano Letters, Journal Year: 2024, Volume and Issue: 24(37), P. 11738 - 11746

Published: Sept. 4, 2024

Fluoride-based lanthanide-doped nanoparticles (LDNPs) featuring second near-infrared (NIR-II, 1000-1700 nm) downconversion emission for bioimaging have attracted extensive attention. However, conventional LDNPs cannot be degraded and eliminated from organisms because of an inert lattice, which obstructs applications. Herein, the core-shell Na

Language: Английский

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Recent advances in biomimetic nanodelivery systems for the treatment of myocardial ischemia reperfusion injury

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 247, P. 114414 - 114414

Published: Nov. 28, 2024

Language: Английский

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Hyaluronan Like Polysaccharide Based Nanodrugs with Enhanced Cd44 Avidity for Image-Guided Drug Delivery to Breast Cancer

Published: Jan. 1, 2024

Language: Английский

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