Targeted Delivery of STING Agonist via Albumin Nanoreactor Boosts Immunotherapeutic Efficacy against Aggressive Cancers DOI Creative Commons

Zhijun Miao,

Song Xue,

Anan Xu

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1216 - 1216

Published: Sept. 17, 2024

Activating the cytosolic innate immune sensor, cGAS-STING pathway, holds great promise for enhancing antitumor immunity, particularly in combination with checkpoint inhibitors (ICIs). However, clinical application of STING agonists is often hindered by poor tumor accumulation, limited cellular uptake, and rapid clearance. To address these challenges, we developed a human serum albumin (HSA)-based nanoreactor system efficient delivery agonist SR-717, aiming to improve its efficacy.

Language: Английский

Bioinspired micro-nano hierarchical delivery system for sequential targeted therapy of inflammatory bowel disease DOI

Peipei Xi,

Xiangyu Wei,

Yongxin Xu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155215 - 155215

Published: Aug. 28, 2024

Language: Английский

Citations

0
Targeted Delivery of STING Agonist via Albumin Nanoreactor Boosts Immunotherapeutic Efficacy against Aggressive Cancers DOI Creative Commons

Zhijun Miao,

Song Xue,

Anan Xu

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1216 - 1216

Published: Sept. 17, 2024

Activating the cytosolic innate immune sensor, cGAS-STING pathway, holds great promise for enhancing antitumor immunity, particularly in combination with checkpoint inhibitors (ICIs). However, clinical application of STING agonists is often hindered by poor tumor accumulation, limited cellular uptake, and rapid clearance. To address these challenges, we developed a human serum albumin (HSA)-based nanoreactor system efficient delivery agonist SR-717, aiming to improve its efficacy.

Language: Английский

Citations

0