Physics of Fluids,
Journal Year:
2024,
Volume and Issue:
36(9)
Published: Sept. 1, 2024
The
paper
contains
a
preliminary
study
on
the
role
that
dynamic
pressure
might
play
in
dynamics
of
gas
bubble
oscillating
liquid.
To
this
aim,
we
introduce
mathematical
model,
proposed
under
homobaricity
hypothesis
and
deduced
from
14-moment
theory
rational
extended
thermodynamics
through
significant
simplifications,
makes
equations
easily
integrable
over
long
time
intervals.
In
presence
with
high
bulk
viscosity,
relevant
effects
can
be
observed
different
physical
conditions:
isothermal
or
adiabatic
regimes,
small
amplitude
oscillations,
non-linear
resonances,
sonoluminescence.
make
more
realistic,
always
refer
to
carbon
dioxide
gas,
which
one
hand
could
present
values
viscosity
other
is
known
for
its
peculiar
behaviors
framework
cavitation
bubbles.
Frontiers in Chemical Biology,
Journal Year:
2024,
Volume and Issue:
3
Published: April 5, 2024
Engaging
the
immune
sensing
Stimulator
of
Interferon
Genes
(STING)
pathway
has
emerged
as
a
potentially
powerful
approach
to
cancer
therapy.
However,
current
STING
agonists
lack
stability
and
specificity,
resulting
in
toxic
adverse
effects
disappointing
patient
outcomes.
Therefore,
novel
delivery
vehicles
are
needed
mitigate
negative
results
improve
efficacy
agonists.
Here
we
discuss
innovative
particle-based
strategies
how
they
have
increased
therapeutic
seen
with
We
review
ultrasound-responsive
vehicles,
pH-responsive
particles,
inorganic
carriers
for
extended
release,
particles
that
act
both
and/or
drug
carriers.
Further
optimization
these
can
enable
clinical
use
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(8), P. e0308075 - e0308075
Published: Aug. 1, 2024
Nitric
oxide
(NO)
regulates
vascular
homeostasis
and
plays
a
key
role
in
revascularization
angiogenesis.
The
endothelial
nitric
synthase
(eNOS)
enzyme
catalyzes
NO
production
cells.
Overexpression
of
the
eNOS
gene
has
been
implicated
pathologies
with
dysfunctional
angiogenic
processes,
such
as
cancer.
Therefore,
modulating
expression
using
small
interfering
RNAs
(siRNAs)
represents
viable
strategy
for
antitumor
therapy.
siRNAs
are
highly
specific
to
target
gene,
thus
reducing
off-target
effects.
Given
widespread
distribution
endothelium
crucial
physiological
eNOS,
localized
delivery
nucleic
acid
affected
area
is
essential.
development
an
efficient
eNOS-siRNA
carrier
capable
controlled
release
imperative
targeting
regions,
particularly
those
associated
tumor
growth.
Thus,
this
study
aims
utilize
ultrasound-mediated
microbubble
destruction
(UMMD)
technology
cationic
microbubbles
loaded
enhance
transfection
efficiency
improve
siRNA
delivery,
thereby
preventing
sprouting
facilitated
by
UMMD
was
assessed
bEnd.3
Synthesis
protein
were
also
evaluated.
silencing
model
angiogenesis
assayed
rat
aortic
ring
assay.
results
showed
that
from
6
24
h,
fluorescent
twice
high
lipofection.
Moreover,
enhanced
knockdown
level
(65.40
±
4.50%)
compared
lipofectamine
(40
1.70%).
Silencing
required
less
amount
(42
ng)
decrease
(52.30
0.08%)
same
extent
79
ng
(56.30
0.10%).
assisted
reduced
81%
67%
reduction
transfecting
lipofectamine.
This
diminished
led
higher
attenuation
outgrowth.
Three-fold
transfection.
In
conclusion,
we
propose
combination
efficient,
safe,
non-viral
inhibition
progression.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 29, 2024
Abstract
Locally
opening
up
the
endothelial
barrier
in
a
safe
and
controlled
way
is
beneficial
for
drug
delivery
into
extravascular
tissue.
Although
ultrasound-induced
microbubble
oscillations
can
affect
integrity,
mechanism
remains
unknown.
Here
we
uncover
new
role
F-actin
microbubble-mediated
gap
formation.
Unique
simultaneous
high-resolution
confocal
microscopy
ultra-high-speed
camera
imaging
(10
million
frames
per
second)
reveal
that
oscillating
microbubbles
(radius
1.3-3.8
µm)
induce
sonoporation
all
cells
which
remodeling
occurred.
disruption
only
mainly
resulted
tunnel
formation
(75%)
stress
fiber
severing
recoil
cell-cell
contact
within
15
s
upon
treatment
(54%)
(15%).
Stress
occurred
when
fibers
were
reach
of
microbubble’s
maximum
radius
during
oscillation,
requiring
normal
forces
≥230
nN.
Together,
these
findings
novel
delivery,
associates
with
underlying
cytoskeletal
organization.
Physics of Fluids,
Journal Year:
2024,
Volume and Issue:
36(9)
Published: Sept. 1, 2024
The
paper
contains
a
preliminary
study
on
the
role
that
dynamic
pressure
might
play
in
dynamics
of
gas
bubble
oscillating
liquid.
To
this
aim,
we
introduce
mathematical
model,
proposed
under
homobaricity
hypothesis
and
deduced
from
14-moment
theory
rational
extended
thermodynamics
through
significant
simplifications,
makes
equations
easily
integrable
over
long
time
intervals.
In
presence
with
high
bulk
viscosity,
relevant
effects
can
be
observed
different
physical
conditions:
isothermal
or
adiabatic
regimes,
small
amplitude
oscillations,
non-linear
resonances,
sonoluminescence.
make
more
realistic,
always
refer
to
carbon
dioxide
gas,
which
one
hand
could
present
values
viscosity
other
is
known
for
its
peculiar
behaviors
framework
cavitation
bubbles.
