bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 3, 2024
Abstract
Background
Tissue
regeneration
heavily
relies
on
cellular
energy
production,
with
mitochondria
playing
a
crucial
role.
Dysfunctional
are
implicated
in
various
degenerative
diseases,
driving
interest
targeting
mitochondrial
transplantation
for
tissue
repair.
Wound
healing
is
highly
compromised
gastrointestinal
conditions
resulting
fistula
development,
particularly
after
sleeve
gastrectomy.
Human
mesenchymal
stem/stromal
cells
(hMSCs)
and
their
cell-free
products
such
as
offer
potential
benefits
due
to
therapeutic
properties
production.
Here
we
investigated
the
advantage
of
hMSCs-derived
nano-biotherapy
rat
model
post-surgical
healing.
Methods
Viable
structurally
intact
were
isolated
from
hMSCs
before
exposure
human
colonic
epithelial
(HCEC-1CT)
culture
or
into
post-operative
fistula.
Results
Our
findings
reveal
significant
dose-dependent
improvement
metabolic
activity
ATP
content
recipient
cells.
Assessment
external
orifice
developed
following
post
gastrectomy
fistula,
revealed
substantial
all
transplanted
rats
compared
control
group.
Conclusion
highlight
This
research
contributes
advancing
regenerative
strategies
conditions,
offering
new
insights
mitochondrial-based
therapies
enhancing
wound
Cell Biochemistry and Function,
Journal Year:
2024,
Volume and Issue:
42(5)
Published: June 28, 2024
Stem
cells
demonstrate
differentiation
and
regulatory
functions.
In
this
discussion,
we
will
explore
the
impacts
of
cell
culture
density
on
stem
proliferation,
adipogenesis,
abilities.
This
study
aimed
to
investigate
impact
initial
human
periodontal
ligament
(hPDLSCs)
adipogenic
autologous
cells.
Our
findings
indicate
that
proliferation
rate
hPDLSCs
increased
with
increasing
(0.5-8
×
10
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 3, 2024
Abstract
Background
Tissue
regeneration
heavily
relies
on
cellular
energy
production,
with
mitochondria
playing
a
crucial
role.
Dysfunctional
are
implicated
in
various
degenerative
diseases,
driving
interest
targeting
mitochondrial
transplantation
for
tissue
repair.
Wound
healing
is
highly
compromised
gastrointestinal
conditions
resulting
fistula
development,
particularly
after
sleeve
gastrectomy.
Human
mesenchymal
stem/stromal
cells
(hMSCs)
and
their
cell-free
products
such
as
offer
potential
benefits
due
to
therapeutic
properties
production.
Here
we
investigated
the
advantage
of
hMSCs-derived
nano-biotherapy
rat
model
post-surgical
healing.
Methods
Viable
structurally
intact
were
isolated
from
hMSCs
before
exposure
human
colonic
epithelial
(HCEC-1CT)
culture
or
into
post-operative
fistula.
Results
Our
findings
reveal
significant
dose-dependent
improvement
metabolic
activity
ATP
content
recipient
cells.
Assessment
external
orifice
developed
following
post
gastrectomy
fistula,
revealed
substantial
all
transplanted
rats
compared
control
group.
Conclusion
highlight
This
research
contributes
advancing
regenerative
strategies
conditions,
offering
new
insights
mitochondrial-based
therapies
enhancing
wound
