Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 217, P. 115482 - 115482
Published: Nov. 29, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139551 - 139551
Published: Jan. 7, 2025
Language: Английский
Citations
2
Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 126541 - 126541
Published: Nov. 1, 2024
Language: Английский
Citations
4
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124995 - 124995
Published: Nov. 1, 2024
Language: Английский
Citations
4
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Language: Английский
Citations
0
Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
Transdermal patches offer a unique advantage by providing extended therapeutic benefits while maintaining stable plasma drug concentration. The efficacy and safety of depend significantly on their ability to adhere the skin, feature influenced various external internal factors. review primarily focuses fundamental aspects adhesion in transdermal patches, including basic information about underlying principles adhesion, delivery, characteristics pressure sensitive adhesives (PSAs), issues, impact factors, strategies improve patch relevant molecular mechanisms. development with sufficient for consistent delivery remains challenging task. Challenges stem from complex interplay among PSAs, permeation enhancers, active pharmaceutical ingredients (APIs), other excipients current compositions, further complicated variations arising dermatological These intricacies impede effectiveness patches. Progress exploration new PSA polymers, conjunction innovative is crucial establishing an optimal equilibrium between utilization rate, drug-loading, release, thus effectively addressing challenges related adhesion.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 303, P. 140657 - 140657
Published: Feb. 3, 2025
Language: Английский
Citations
0
Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Abstract Buspirone hydrochloride (BSP) is an anxiolytic agent approved for the management of anxiety disorders. The current US-FDA medications BSP are administered via oral route, which linked to several disadvantages such as low bioavailability and half-life necessitating multiple daily doses. For chronic diseases disorders, where long-term or lifelong often required, these factors impact patient compliance treatment adherence. present study offers alternative approach by investigating feasibility sustained transdermal delivery long-acting microneedles (MNs). Needle-tip-loaded MNs were fabricated micro-molding technique using various grades poly-vinyl alcohol (PVA) namely 4–88, 8–88, 18–88, 26–88. These compared characterization techniques Parafilm ® insertion testing, scanning electron microscopy (SEM), confocal microscopy, Fourier transform infrared spectroscopy (FTIR), histological evaluation MNs-treated human skin. effect different PVA on structural mechanical properties was evaluated. Further, in vitro release permeation tests conducted assess drug patterns across dermatomed skin over 7-day periods. highest (5507.37 ± 456.88 µg/cm 2 ) (4705.42 634.57 observed from with significant differences among based their properties. Notably, all four types crossed weekly therapeutic targets systemic BSP. Overall, this established Graphical
Language: Английский
Citations
0
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 251, P. 114604 - 114604
Published: March 5, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
For highly efficient and precise drug release, transdermal delivery systems (TDDS) have recently evolved through the combination of intelligent material-based structures with various active components. These strategies are an effort to overcome significant difficulties in delivering large molecule drugs nanomaterials due physical barrier skin, especially stratum corneum, traditional TDDS. Interestingly, multiscale suction-driven architectures (SDAs) inspired by bioinspired suction adhesion mechanisms provided innovative solutions these challenges. employ negative pressure enhance nanoscale skin-controllable skin adhesion, temporarily bypass barrier, facilitate deep penetration therapeutic agents, thereby, achieving goals increasing efficiency maximizing user convenience as a minimal invasive, needle-free platform. This review provides comprehensive overview patches emphasizes their integration multifunctional materials achieve stable controlled release. Next, we present cost-effective user-friendly patch devices optimization cupping without incorporation additional devices. Furthermore, that optimize need for Potential SDAs localized systemic challenging complex well future perspectives, discussed, along directions more patient-centric solutions.
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: April 17, 2025
Language: Английский
Citations
0