Integrating targeting and drug retention: A promising approach for cancer treatment DOI
Shenqiang Wang, Zhiyuan Zhong

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 378, P. 247 - 249

Published: Dec. 14, 2024

Language: Английский

Scaffolds of Chitosan-metallic hybrids as antimicrobial wound dressing DOI
Shengyu Zhang, Muhammad Ali,

Farooq Nawaz

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 126541 - 126541

Published: Nov. 1, 2024

Language: Английский

Citations

4
Molecular Engineering of NIR-II Excitable Phototheranostic for Mitochondria-Targeted Cancer Photoimmunotherapy DOI
Qiang Kang, Fen Liu, Senyou Tan

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

The advancement of mitochondria-targeted near-infrared-II (NIR-II) excitable phototheranostics constitutes a promising strategy for improving fluorescence-image-guided cancer phototherapy. However, developing phototheranostic agents that simultaneously combine high-contrast NIR-II fluorescence imaging with effective multimodal therapeutic techniques remains substantial challenge. Herein, we reported shielding-donor-acceptor-donor-shielding structured (FCD-T) by molecular engineering strategy, followed self-assembly glutathione-responsive copolymer to form FCD-T nanoparticles. introduction functional bithiophene endows significant electron-donating properties and reduces intermolecular π-π stacking interactions. robust π-conjugation fluorene good rigidity would enhance the intramolecular charge transfer capability. Therefore, NPs exhibited an absorption peak at 1075 nm emission 1280 nm. Upon light excitation, such nanoparticles could generate excellent photothermal photodynamic performances biocompatibility. Moreover, phototherapy further facilitated mitochondrial apoptosis-related pathways, activating antitumor immunity inhibiting tumor growth single irradiation low doses.

Language: Английский

Citations

0
Enzyme‐Instructed Self‐Assembly Reprograms Fatty Acid Metabolism for Cancer Therapeutics DOI
Hongjian He, Haonan Lin, Leo Wang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Enzyme‐instructed self‐assembly (EISA) is actively explored as a promising therapeutic approach for cancer treatment. However, the metabolic response of cells to EISA remains under‐studied. Here, by stimulated Raman scattering (SRS) imaging in C─H, fingerprint, and silent windows, it found that formation peptide assemblies within around significantly enhances both lipids catabolism fatty acids (FAs) uptake. It further increased uptake FAs aids resistance under treatment, likely cope with stress induced assemblies. Combining inhibition leads enhanced suppression compared alone, while additional supplementation rescue from vitro 3D‐culture spheroid models. These findings shed new light on impact activities suggest improved therapy.

Language: Английский

Citations

0
A two-component peptide-based hydrogel for endometrial repair and restoring fertility DOI

Weiqi Zhang,

Hang Wu, Li‐Min Xie

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110800 - 110800

Published: Dec. 1, 2024

Language: Английский

Citations

1
Peptide-Amphiphilic Nanoassemblies as a Responsive Senolytic Navigator for Targeted Removal of Senescent Cardiomyocytes to Ameliorate Heart Failure DOI
Zhiye Wu, Yinghua Zeng,

Hui-Ming Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Heart failure (HF) represents the terminal stage of numerous cardiovascular disorders and lacks effective therapeutic strategies. The accumulation senescent cardiomyocytes is a cardinal characteristic HF, contributing to myocardial dysfunction deteriorating microenvironment through development senescence-associated secretory phenotypes (SASPs), ultimately culminating in pathological remodeling. Senolytics, promising strategy that selectively induces apoptosis cells, faces challenges due nonspecific effects, raising concerns for clinical implementation. In this study, we developed peptide-amphiphilic nanoassemblies as responsive drug navigators targeted delivery. modular comprise hydrophilic domain containing CD9-binding peptide, hydrophobic incorporating reactive oxygen species (ROS)-responsive motif, an alkyl tail encapsulation senolytic ABT263. CD9-targeted ROS-responsive (AP@ABT263) specifically recognized modulated release ABT263 presence elevated intracellular ROS levels. AP@ABT263 treatment significantly enhanced delivery cells both vitro vivo while showing minimal toxicity normal other tissues. Our findings provide compelling evidence efficiently eradicated cardiomyocytes, cardiac function, attenuated deleterious effects SASP, thereby preventing adverse summary, highly approach controlled providing valuable insights into intelligent pharmaceutical interventions management HF.

Language: Английский

Citations

0
Super-resolution imaging of sub-cellular dynamics of drug molecules DOI
Qixin Chen,

Jiajia Diao

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 115455 - 115455

Published: Sept. 1, 2024

Language: Английский

Citations

0
Optimizing mitochondrial-targeting groups of positively-charged BODIPY nanoparticles for enhanced photodynamic therapy DOI
Huixuan Qi,

Ruobing Qu,

Jiaping Shen

et al.

Materials Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 8(23), P. 3898 - 3905

Published: Jan. 1, 2024

1-Methylimidazole-modified BODIPY nanoprobes were developed for highly efficient mitochondrial targeting and enhanced photo dynamic therapy.

Language: Английский

Citations

0
Integrating targeting and drug retention: A promising approach for cancer treatment DOI
Shenqiang Wang, Zhiyuan Zhong

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 378, P. 247 - 249

Published: Dec. 14, 2024

Language: Английский

Citations

0