Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 422 - 422
Published: Feb. 10, 2025
The
intricate
relationship
between
anticancer
drugs
and
the
gut
microbiome
influences
cancer
treatment
outcomes.
This
review
paper
focuses
on
role
of
integrity
in
enhancing
efficacy
safety
drug
therapy,
emphasizing
pharmacokinetic
interactions
microbiota.
It
explores
how
disruptions
to
composition,
or
dysbiosis,
can
alter
metabolism,
immune
responses,
side
effects.
By
examining
mechanisms
disruption
caused
by
drugs,
this
highlights
specific
case
studies
like
cyclophosphamide,
5-fluorouracil,
irinotecan,
their
impact
microbial
diversity
clinical
also
discusses
microbiome-targeted
strategies,
including
prebiotics,
probiotics,
postbiotics,
fecal
microbiota
transplantation
(FMT),
as
promising
interventions
enhance
treatment.
Furthermore,
potential
profiling
personalizing
therapy
integrating
these
into
practice
is
explored.
Finally,
proposes
future
research
directions,
developing
novel
biomarkers
a
deeper
comprehension
drug-microbiome
interactions,
respond
current
gaps
knowledge
improve
patient
outcomes
care.
Language: Английский
Microbial molecules, metabolites, and malignancy
Neoplasia,
Journal Year:
2025,
Volume and Issue:
60, P. 101128 - 101128
Published: Jan. 18, 2025
Language: Английский
Targeting Tumor-Associated Microbiome: A New Aspect of Modulating Tumor Microenvironment for Cancer Therapy
Advanced Drug Delivery Reviews,
Journal Year:
2025,
Volume and Issue:
unknown, P. 115554 - 115554
Published: March 1, 2025
Language: Английский
A syringeable immunotherapeutic hydrogel enhances T cell immunity via in-situ activation of STING pathway for advanced breast cancer postoperative therapy
Baozhen Zhang,
No information about this author
Min Li,
No information about this author
Jiahua Ji
No information about this author
et al.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 19, 2025
Complete
surgical
resection
of
advanced
breast
cancer
is
highly
challenging
and
often
leaves
behind
microscopic
tumor
foci,
leading
to
inevitable
relapse.
Postoperative
formation
the
immunosuppressive
microenvironment
(TME)
reduces
efficacy
immunotherapies
against
residual
tumors.
Although
cytotoxic
chemotherapeutics
exert
capacity
intensify
immunotherapy
via
immunogenic
cell
death
(ICD)
effects,
systemically
administered
chemo
agents
cannot
access
sites,
fail
elicit
antitumor
immune
responses.
Herein,
we
present
a
novel
syringeable
immunotherapeutic
hydrogel
(SiGel@SN38/aOX40)
loaded
with
DNA-targeting
chemotherapeutic
7-ethyl-10-hydroxycamptothecin
(SN38)
anti-OX40
agonist
antibody
(aOX40).
The
sustained
in-site
release
SN38
aOX40
activate
stimulator
interferon
genes
(STING)
pathway,
type
I
interferons
expression,
synergistically
facilitate
dendritic
(DC)
activation,
initiate
persistent
T
mediated
responses
within
bed
that
eliminate
tumors
no
recurrence
in
120
days.
Collectively,
our
designed
SiGel@SN38/aOX40
induces
robust
long-lasting
tumoricidal
immunity
following
exhibit
immense
potential
for
clinical
translation.
Language: Английский
Engineering advanced bacterial therapy for tumor and inflammatory diseases
International Journal of Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown, P. 125585 - 125585
Published: April 1, 2025
Language: Английский
In vitro screening of Lactiplantibacillus plantarum with probiotic properties and anti-colon cancer potential
Xiaoyan Xu,
No information about this author
Shijin Xiong,
No information about this author
Tonghao Du
No information about this author
et al.
Food Bioscience,
Journal Year:
2024,
Volume and Issue:
unknown, P. 105569 - 105569
Published: Nov. 1, 2024
Language: Английский
Modulação da Microbiota Intestinal como Estratégia Terapêutica no Tratamento do Melanoma
Tuany Caroline Bernardi,
No information about this author
Vanessa Mazzardo,
No information about this author
Isabele Dallacort
No information about this author
et al.
Brazilian Journal of Implantology and Health Sciences,
Journal Year:
2024,
Volume and Issue:
6(8), P. 2875 - 2883
Published: Aug. 19, 2024
A
microbiota
intestinal,
uma
comunidade
complexa
de
microrganismos,
tem
emergido
como
modulador
crucial
na
homeostase
do
hospedeiro
e
resposta
a
doenças
o
melanoma,
um
câncer
pele
altamente
agressivo.
Este
artigo
revisa
os
mecanismos
pelos
quais
influencia
desenvolvimento,
progressão
terapêutica
melanoma.
interação
entre
sistema
imunológico
é
analisada,
mostrando
microrganismos
comensais
modulam
imune
inata
adaptativa
por
meio
da
com
células
dendríticas,
macrófagos,
linfócitos
T,
produção
citocinas
quimiocinas.
Também
se
discute
impacto
metabólitos
microbianos,
ácidos
graxos
cadeia
curta,
biliares
secundários
compostos
fenólicos
derivados
dieta,
sinalização
celular
modulação
microambiente
tumoral.
Estrategias
emergentes,
uso
probióticos,
prebióticos,
antibióticos
seletivos,
transplante
fecal
intervenções
dietéticas,
são
avaliadas
pelo
seu
potencial
em
otimizar
mitigar
efeitos
adversos.
integração
abordagens
baseadas
microbiana
pode
transformar
tratamento
melhorando
eficácia
qualidade
vida
dos
pacientes.
Futuras
pesquisas
devem
focar
personalização
dessas
intervenções,
considerando
composição
individual
pacientes
subjacentes
essas
interações.