Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Targeted regulation of pyroptosis to modulate the immune landscape has emerged as a novel design strategy for cancer immunotherapy and anti‐inflammatory therapy. However, acts double‐edged sword, making it important optimize strategies functional materials appropriately activate effective disease treatment. This paper summarizes discusses structure, pore formation, molecular mechanisms “executor” Gasdermins, well events preceding following these processes. Subsequently, focus is on reviewing that directly regulate Gasdermin formation target those indirectly before after control activity. Finally, advantages, disadvantages, future prospects designing such are provided, aiming facilitate precise design, pharmacological investigation, clinical translation pyroptosis‐related materials.

Language: Английский

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Pioneering Advances and Innovative Applications of Mesoporous Carriers for Mitochondria-Targeted Therapeutics

British Journal of Biomedical Science, Journal Year: 2024, Volume and Issue: 81

Published: Nov. 18, 2024

Mitochondria, known as the cell’s powerhouse, play a critical role in energy production, cellular maintenance, and stemness regulation non-cancerous cells. Despite their importance, using drug delivery systems to target mitochondria presents significant challenges due several barriers, including uptake limitations, enzymatic degradation, mitochondrial membranes themselves. Additionally, barriers organs be targetted, along with extracellular formed by physiological processes such reticuloendothelial system, contribute rapid elimination of nanoparticles designed for mitochondrial-based delivery. Overcoming these has led development various strategies, molecular targeting cell-penetrating peptides, genomic editing, nanoparticle-based systems, porous carriers, liposomes, micelles, Mito-Porters. Porous carriers stand out particularly promising candidates large pore size, surface area, ease functionalisation. Depending on they can classified micro-, meso-, or macroporous are either ordered non-ordered based both size uniformity. Several methods employed modifications polyethylene glycol (PEG), incorporation ligands like triphenylphosphonium, capping pores gold chitosan enable controlled triggered Photodynamic therapy is another approach, where drug-loaded generate reactive oxygen species (ROS) enhance targeting. Further advancements have been made form functionalised silica carbon nanoparticles, which demonstrated potential effective mitochondria. This review highlights approaches that utilise specifically focusing silica-based efficient vehicles mitochondria, paving way improved strategies therapies.

Language: Английский

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Optimizing mitochondrial-targeting groups of positively-charged BODIPY nanoparticles for enhanced photodynamic therapy

Materials Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 8(23), P. 3898 - 3905

Published: Jan. 1, 2024

1-Methylimidazole-modified BODIPY nanoprobes were developed for highly efficient mitochondrial targeting and enhanced photo dynamic therapy.

Language: Английский

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Editorial: Subcellular organelle-targeting of nanomaterials for enhancing therapeutic effectiveness

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 115460 - 115460

Published: Oct. 1, 2024

Language: Английский

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