Unlocking the Potential of Disulfidptosis: Nanotechnology‐Driven Strategies for Advanced Cancer Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Tumor tissues exhibit elevated oxidative stress, with the cystine‐glutamate transporter x CT solute carrier family 7 member 11 ( CT/SLC7A11) protecting cancer cells from damage by facilitating cystine uptake for glutathione synthesis. Disulfidptosis, a newly identified form of programmed cell death (PCD), occurs in high CT/SLC7A11 expression under glucose‐deprived conditions. Distinct other PCD pathways, disulfidptosis is characterized aberrant disulfide bond formation and cellular dysfunction, ultimately resulting death. This novel mechanism offers remarkable therapeutic potential targeting inherent stress vulnerabilities rapidly growing cells. Advances nanotechnology enable development nanomaterials capable inducing reactive oxygen species (ROS) generation, disrupting bonds. In addition, they are to deliver agents directly tumors, thereby improving precision minimizing off‐target effects. Moreover, combining ROS‐induced immunogenic can remodel tumor microenvironment enhance anti‐tumor immunity. review explores mechanisms underlying disulfidptosis, its treatment, synergistic role amplifying Selective induction using represents promising strategy achieving more effective, selective, less toxic therapies.

Language: Английский

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Electrospun Nanofiber Platforms for Photodynamic Therapy: Role and Efficacy in Cancer, Antimicrobial, and Wound Healing Applications

Macromolecular Materials and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Electrospinning offers a versatile platform for developing nanofibrous scaffolds capable of enhancing the therapeutic potential photodynamic therapy (PDT). Photosensitizer (PS) loaded fibers exhibit high surface area‐to‐volume ratio, promoting efficient drug delivery, prolonged retention at target site, and controlled release profiles. Inducing reactive oxygen species (ROS) generation through light activation targeted approach, selectively generating cytotoxic effects in cancerous or pathogenic cells while minimizing damage to healthy tissue. This selective cytotoxicity arises because ROS are produced only illuminated areas where PS releases accumulates, limiting their harmful desired regions. Additionally, PS‐loaded highly effective wound healing applications, cell proliferation tissue regeneration providing barrier against microbial infections. review highlights recent advances design biomedical application nanofibers, emphasizing influence on viability effectiveness inhibition, thereby setting stage future innovations cancer therapy, healing, infection control.

Language: Английский

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Implantable Biomaterials for Cancer Immunotherapies

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Abstract Cancer immunotherapy has revolutionized cancer treatment by leveraging the immune system to target and eliminate tumor cells. Implantable biomaterials, such as hydrogels, sponges, scaffolds, implantable microdevice platforms, macrobeads, offer localized sustained release of immunomodulatory agents, improving delivery treatments checkpoint inhibitors, vaccines, adoptive cell therapies like CAR‐T This review examines emerging role these biomaterials in modulating microenvironment, enhancing recruitment, reducing systemic side effects, positioning them significant tools for treating solid tumors. Recent advances material engineering are also discussed, including integration bioactive molecules real‐time therapeutic adjustments based on patient‐specific responses, which new potential personalized treatments. However, challenges biocompatibility, high production costs, variability patient response, necessity surgical manipulations remain key obstacles. Nonetheless, ongoing research technological advancements steadily addressing issues, paving way more effective accessible immunotherapies. Overall, this highlights promise overcoming current limitations expanding scope effective, targeted

Language: Английский

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Editorial: Subcellular organelle-targeting of nanomaterials for enhancing therapeutic effectiveness

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 115460 - 115460

Published: Oct. 1, 2024

Language: Английский

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