Efficient Artificial T Cell Therapy for Bacterial‐Colonized Tumors DOI
Shiyu Zhang, Han Zhu, Xiaohui Peng

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: June 1, 2025

Abstract Tumor‐colonizing bacteria can impede the efficacy of cancer treatments and elevate risk metastatic spread. While cytotoxic T lymphocytes (CTLs) are essential for destroying tumor cells, they lack ability to eliminate bacteria. Here, artificial cells (ATC) presented tumors, particularly those colonized with intracellular The ATC is composed a hydrogel framework made disulfide‐linked chitosan hyaluronic acid, encapsulating cell‐derived granzyme B phage‐derived holin. This design leverages microenvironment targeted release these antitumor antibacterial agents precisely kill In vivo studies demonstrate debris from ATC‐mediated destruction acts as an immune stimulator, promoting cell infiltration inhibiting migration. work highlights potential therapy in achieving treatment robust anti‐tumor immunity, advancing field technologies precision medicine.

Language: Английский

Borrow Strength to Exert: Low‐Crystallinity Prussian Blue for Reduction Overload Enhanced Photothermal Therapy DOI Open Access

Yuxin Yao,

Junlie Yao,

Shiyi Xiong

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract The strategy “Borrow strength to exert” in Sun Tzu's Art of War refers borrowing external forces withstand the enemy. Inspired by this, applying this thought cancer treatment can achieve a more efficient therapeutic effect. Therefore, fulcrum borrow force is vital and significant. Compared with normal cells, tumor cells are sensitive redox stress owing their abnormal metabolism. Herein, regulatory protocol based on chloroauric acid (HAuCl 4 ) proposed prepare small‐size low‐crystallinity Prussian blue nanoparticles (LcPB NPs). Notably, LcPB NPs possess higher superoxide dismutase (SOD)‐like enzyme activity induce reduction overload destroy metabolic processes organelle functions, which leverages status defect tumors as fulcrum. Due down‐regulation heat shock proteins (HSPs) mediated imbalance, inherent photothermal therapy (PTT) mode effectively inhibits growth disrupts calcium homeostasis. Additionally, improve anticancer effect inhibiting symbiotic bacteria. Meanwhile, magnetic optical response performance empowers resonance imaging (MRI) photoacoustic (PAI) for diagnosis. work executing “Borrowing disturbing balance represents new antineoplastic paradigm.

Language: Английский

Citations

0
Targeting Tumor-Associated Microbiome: A New Aspect of Modulating Tumor Microenvironment for Cancer Therapy DOI
Wantong Song, Leaf Huang

Advanced Drug Delivery Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 115554 - 115554

Published: March 1, 2025

Language: Английский

Citations

0
Efficient Artificial T Cell Therapy for Bacterial‐Colonized Tumors DOI
Shiyu Zhang, Han Zhu, Xiaohui Peng

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: June 1, 2025

Abstract Tumor‐colonizing bacteria can impede the efficacy of cancer treatments and elevate risk metastatic spread. While cytotoxic T lymphocytes (CTLs) are essential for destroying tumor cells, they lack ability to eliminate bacteria. Here, artificial cells (ATC) presented tumors, particularly those colonized with intracellular The ATC is composed a hydrogel framework made disulfide‐linked chitosan hyaluronic acid, encapsulating cell‐derived granzyme B phage‐derived holin. This design leverages microenvironment targeted release these antitumor antibacterial agents precisely kill In vivo studies demonstrate debris from ATC‐mediated destruction acts as an immune stimulator, promoting cell infiltration inhibiting migration. work highlights potential therapy in achieving treatment robust anti‐tumor immunity, advancing field technologies precision medicine.

Language: Английский

Citations

0