Borrow Strength to Exert: Low‐Crystallinity Prussian Blue for Reduction Overload Enhanced Photothermal Therapy
Yuxin Yao,
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Junlie Yao,
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Shiyi Xiong
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et al.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Abstract
The
strategy
“Borrow
strength
to
exert”
in
Sun
Tzu's
Art
of
War
refers
borrowing
external
forces
withstand
the
enemy.
Inspired
by
this,
applying
this
thought
cancer
treatment
can
achieve
a
more
efficient
therapeutic
effect.
Therefore,
fulcrum
borrow
force
is
vital
and
significant.
Compared
with
normal
cells,
tumor
cells
are
sensitive
redox
stress
owing
their
abnormal
metabolism.
Herein,
regulatory
protocol
based
on
chloroauric
acid
(HAuCl
4
)
proposed
prepare
small‐size
low‐crystallinity
Prussian
blue
nanoparticles
(LcPB
NPs).
Notably,
LcPB
NPs
possess
higher
superoxide
dismutase
(SOD)‐like
enzyme
activity
induce
reduction
overload
destroy
metabolic
processes
organelle
functions,
which
leverages
status
defect
tumors
as
fulcrum.
Due
down‐regulation
heat
shock
proteins
(HSPs)
mediated
imbalance,
inherent
photothermal
therapy
(PTT)
mode
effectively
inhibits
growth
disrupts
calcium
homeostasis.
Additionally,
improve
anticancer
effect
inhibiting
symbiotic
bacteria.
Meanwhile,
magnetic
optical
response
performance
empowers
resonance
imaging
(MRI)
photoacoustic
(PAI)
for
diagnosis.
work
executing
“Borrowing
disturbing
balance
represents
new
antineoplastic
paradigm.
Language: Английский
Targeting Tumor-Associated Microbiome: A New Aspect of Modulating Tumor Microenvironment for Cancer Therapy
Advanced Drug Delivery Reviews,
Journal Year:
2025,
Volume and Issue:
unknown, P. 115554 - 115554
Published: March 1, 2025
Language: Английский
Efficient Artificial T Cell Therapy for Bacterial‐Colonized Tumors
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: June 1, 2025
Abstract
Tumor‐colonizing
bacteria
can
impede
the
efficacy
of
cancer
treatments
and
elevate
risk
metastatic
spread.
While
cytotoxic
T
lymphocytes
(CTLs)
are
essential
for
destroying
tumor
cells,
they
lack
ability
to
eliminate
bacteria.
Here,
artificial
cells
(ATC)
presented
tumors,
particularly
those
colonized
with
intracellular
The
ATC
is
composed
a
hydrogel
framework
made
disulfide‐linked
chitosan
hyaluronic
acid,
encapsulating
cell‐derived
granzyme
B
phage‐derived
holin.
This
design
leverages
microenvironment
targeted
release
these
antitumor
antibacterial
agents
precisely
kill
In
vivo
studies
demonstrate
debris
from
ATC‐mediated
destruction
acts
as
an
immune
stimulator,
promoting
cell
infiltration
inhibiting
migration.
work
highlights
potential
therapy
in
achieving
treatment
robust
anti‐tumor
immunity,
advancing
field
technologies
precision
medicine.
Language: Английский