International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125513 - 125513
Published: March 1, 2025
Language: Английский
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125217 - 125217
Published: Jan. 1, 2025
Language: Английский
Citations
1
Pharmaceutical Development and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14
Published: March 4, 2025
The goal of this study was to explore the fabrication a combination drug product containing two poorly soluble active pharmaceutical ingredients (APIs), carvedilol (CAR) and simvastatin (SIM), in therapeutically relevant doses (25 mg each API) with distinct, easily distinguishable shape. Fused deposition modelling, combined hot-melt extrusion (HME), used produce hollow heart-shaped dual-loaded tablets which APIs were spatially separated an intermediate API-free layer. Water-soluble hydroxypropyl methylcellulose varying molecular weights as primary polymer for HME. incorporation processability-improving polymer, such polycaprolactone, necessary facilitate printing these delicate geometries lower temperature. 3D-printed contained therapeutic both APIs; however, further optimization manufacturing processes is required improve content uniformity. release from printed sustained, complete CAR observed after 24 hours, demonstrating suitability designed products oral delivery.
Language: Английский
Citations
0
Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 187 - 187
Published: March 8, 2025
Over the past years, numerous novel dosage forms, including gels, have been investigated for paediatric treatment due to need provide flexible dose adjustment possibilities, as well a patient-friendly approach drug delivery. Simultaneously, 3D printing technology is continuously advancing and gaining interest tool personalised formulation development. Multiple additive manufacturing methods, semi-solid extrusion, especially used in gel printing, flexibility regarding of active ingredients design soft forms. techniques can be considered possible answer demand medicines tailored small patients’ needs. This review intends present an overview current comparing gel-like non-gel-formulated forms crucial aspects developing those cutting-edge by printing. paper discusses formulations such chewing gums, which still require extensive evaluation, explores question three-dimensional process. Furthermore, it highlights gel-based gummies hydrogels, fabrication has intensively studied previous years. However, research needs advance.
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 352 - 352
Published: March 9, 2025
Pharmaceutical 3D printing, combined with nanomaterials and nanodevices, presents a transformative approach to precision medicine for treating neurological diseases. This technology enables the creation of tailored dosage forms controlled release profiles, enhancing drug delivery across blood−brain barrier (BBB). The integration nanoparticles, such as poly lactic-co-glycolic acid (PLGA), chitosan, metallic nanomaterials, into 3D-printed scaffolds improves treatment efficacy by providing targeted prolonged release. Recent advances have demonstrated potential these systems in conditions like Parkinson’s disease, epilepsy, brain tumors. Moreover, printing allows multi-drug combinations personalized formulations that adapt individual patient needs. Novel approaches, including stimuli-responsive systems, on-demand dosing, theragnostics, provide new possibilities real-time monitoring disorders. Despite innovations, challenges remain terms scalability, regulatory approval, long-term safety. future perspectives this suggest its revolutionize treatments offering patient-specific therapies, improved penetration, enhanced outcomes. review discusses current state, applications, nanotechnology treatment, highlighting need further research overcome existing challenges.
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 390 - 390
Published: March 19, 2025
Three-dimensional printing technology is transforming pharmaceutical manufacturing by shifting from conventional mass production to additive manufacturing, with a strong emphasis on personalized medicine. The integration of bioinks and AI-driven optimization further enhancing this innovation, enabling drug precise dosages, tailored drug-release profiles, unique multi-drug combinations that respond individual patient needs. This advancement significantly impacting healthcare accelerating development, encouraging innovative designs, treatment efficacy. Traditional follows one-size-fits-all approach, which often fails meet the specific requirements patients medical conditions. In contrast, 3D printing, coupled bioink formulations, allows for on-demand production, reducing dependency large-scale storage. AI-powered design process refine dosage forms, printability, release mechanisms, ensuring precision efficiency in manufacturing. These advancements have potential lower overall costs while improving adherence medication regimens. review explores potential, challenges, environmental benefits positioning it as key driver next-generation
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125513 - 125513
Published: March 1, 2025
Language: Английский
Citations
0