Smoking, alcohol consumption, drug abuse, and osteoporosis among older adults: a cross-sectional study on PERSIAN cohort study in Fasa

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 22, 2024

Abstract Background With increasing life expectancy and a growing population of older adults, the prevalence osteoporosis has risen, resulting in higher incidence bone fractures, which necessitate extended treatment specialized medical care. This study investigates relationship between smoking, alcohol consumption, drug abuse, among adults southern Iran, utilizing cohort data. Methods cross–sectional is derived from Fasa Adult Cohort Study (FACS), included 10,133 individuals. From this cohort, we selected 1,631 using census sampling methods. Our aimed to explore correlation abuse osteoporosis. We collected demographic information, nutritional indexes, history, glucocorticoid usage, self-reported data on through questionnaires. To investigate alcohol, use with while accounting for confounding factors, employed logistic regression analysis. Results The average age participants was 64.09 ± 3.8 years, majority (898 (55.1%)) being female. Osteoporosis subjects 25.20%. results did not reveal significant ( p > 0.05). Regression analysis identified gender, recent history fractures within past five glucocorticoids, physical activity as predictive risk factors < Conclusion underscores significance addressing adults. Healthcare policymakers administrators can these findings identify mitigate influential contributing demographic.

Language: Английский

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Alcohol in Daily Products: Health Risks, Cultural Considerations, and Economic Impacts

Risk Management and Healthcare Policy, Journal Year: 2025, Volume and Issue: Volume 18, P. 217 - 237

Published: Jan. 1, 2025

Ethanol, a bioactive compound prevalent in both social and industrial applications, is present alcoholic beverages as well range of everyday products. In food, ethanol functions primarily an additive or by-product fermentation, while pharmaceuticals cosmetics, it serves solvent preservative. Despite its widespread use, three critical research gaps exist current literature. First, existing focuses predominantly on single-sector analyses, overlooking the cumulative effects cross-sectoral exposure. Second, despite growing global market integration, there limited understanding how cultural religious requirements influence ethanol-related regulations product formulations. Third, economic models fail to integrate health impact costs compliance expenses, hindering effective policy development. The World Health Organization has determined that no amount alcohol consumption can be considered entirely safe, ethanol's impacts include contributions chronic diseases, neurotoxicity, potential carcinogenic effects. These risks are compounded by pervasive often unrecognized presence various products, particularly affecting vulnerable populations. burden associated with alcohol-related issues, including lost productivity healthcare costs, highlights necessity for robust public strategies stringent regulatory guidelines. This review investigates role across multiple domains, emphasizing medicine, evaluates broader implications health, practices, impact. recommend implementing standardized labeling systems, establishing cultural-sensitive alternatives formulations, developing harmonized international guidelines use industries.

Language: Английский

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Association of Alcohol Use Disorder and Perioperative Complications and Adverse Events After Spinal Fusion Surgery During the In-Hospital Period: An Analysis of the National Inpatient Sample Database

World Neurosurgery, Journal Year: 2025, Volume and Issue: 195, P. 123677 - 123677

Published: Feb. 14, 2025

Alcohol use disorder carries major effects shown to limit social support, increase recovery times, and lead a higher incidence of surgical complications. This retrospective cohort study investigated the influence AUD on perioperative outcomes adverse events after spinal fusions in largest sample size date spanning 11 years. Data for adult (>18 years old) patients who underwent fusion as their primary surgery were identified from Nationwide Inpatient Sample (NIS) database 2009-2020. Patients separated into an no (control) cohort. Univariable multivariable linear logistic regression analyses utilized highlight statistically significant differences complications events. A total 4,896,757 identified. was present 97,565 (2.0%) patients, with remaining serving control group. On analysis, had significantly increased odds longer length stay (odds ratio [OR]=3.40; 95% confidence interval [CI][3.24-3.57]p<0.001, following events: neurologic injury (OR=3.24; CI[3.05-3.44]p<0.001), respiratory-related (OR=3.06; CI[2.91-3.21]p<0.001), systemic infectious (OR=2.79; CI[2.48-3.13]p<0.001), (stroke) (OR=2.73; CI[2.22-3.35])p<0.001, urinary-related (OR=2.23; CI[2.11-2.36]p<0.001), venous thrombotic-related (OR=2.12; 95%[1.87-2.40]p<0.001), gastrointestinal-related (OR:1.91; CI[1.79-2.03]p<0.001), wound-related (OR=2.32; CI[2.10-2.56]p<0.001), cardiac-related (OR=1.44; CI[1.34-1.55]p<0.001), disorders (OR=1.22; CI[1.15-1.2]p<0.001). We found that negative over large population.

Language: Английский

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Quadruple Dislocation Fracture: Concurrent Glenoid, Greater Tuberosity, Coracoid Process, and Acromion Fractures Following Anterior Shoulder Dislocation

JSES Reviews Reports and Techniques, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Ukrainian guideline for the prevention and treatment of glucocorticoid-induced osteoporosis

Archives of Osteoporosis, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 24, 2025

Language: Английский

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Dual‐energy X‐ray absorptiometry and anti‐osteoporotic medication use in Australian patients with early rheumatoid arthritis using data from the Australian Rheumatology Association Database

Internal Medicine Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Abstract Background People with rheumatoid arthritis (RA) are at increased risk of osteoporosis. The Australian Rheumatology Association RA Clinical Care Standard recommends fracture assessment diagnosis and as clinically indicated. Aims aim this study was to evaluate the use dual‐energy X‐ray absorptiometry (DEXA) for osteoporosis screening among patients early enrolled in Database (ARAD). We also aimed assess dispensing patterns anti‐osteoporotic medications population. Methods ARAD participants aged ≥18 years a from 2011 onwards linked 2011–2023 Medicare Benefits Schedule Pharmaceutical Scheme data were included ( n = 306). Time first DEXA medication assessed using Kaplan–Meier failure functions multivariable Cox regression. Covariates age, sex, BMI, alcohol use, smoking glucocorticoid use. Results median time 3 (IQR 0, 10) following diagnosis. Predictors female sex (HR 1.6, 95% CI 1.1, 2.4), age ≥50 2.6, 1.8, 3.9) 1.7, 1.3, 2.4). less likely BMI ≥25 0.68, 0.48, 0.96). By 8 after diagnosis, 25% received medication, predicted by 6.7, 2.1, 21.4) 2.8, 1.5, 5.0). Conclusion Our findings reveal delays variability individuals RA, despite higher risk. Screening practices influenced significant gaps, particularly These gaps highlight need standardised protocols ensure timely scans treatment, ultimately improving management reducing burden.

Language: Английский

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Relationships among osteoporosis, redox homeostasis, and alcohol addiction: Importance of the brain-bone axis

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118063 - 118063

Published: April 19, 2025

Language: Английский

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Lifestyle Medicine Approaches to Bone Health: State of the Field and Future Directions

Lifestyle Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 267 - 297

Published: Jan. 1, 2025

Language: Английский

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Alkol Bağımlılığı Tedavisi Gören Yaşlı Hastaların Sosyodemografik ve Klinik Özellikleri

Bağımlılık Dergisi, Journal Year: 2025, Volume and Issue: 26(3), P. 335 - 346

Published: May 11, 2025

Amaç: Bu çalışmanın amacı, 60 yaş ve üzeri bireylerde alkol kullanım bozukluğunun (AKB) yaygınlığını, sosyodemografik klinik özelliklerini incelemektir. Yöntem: 2019-2023 yılları arasında Manisa Ruh Sağlığı Hastalıkları Hastanesi Bağımlılık Danışmanlığı Polikliniği'ne başvuran AKB tanısı konulan 3892 hasta retrospektif olarak analiz edilmiştir. Hastaların verileri, komorbiditeleri tedavi yaklaşımları değerlendirilmiştir. Bulgular: Çalışmaya dahil edilen bireylerin %93,6'sı erkek, %6,4'ü kadındır. Erkeklerde prevalansı kadınlara göre daha yüksek bulunmuş, ancak pandemi döneminde kadınlarda tüketiminde anlamlı bir artış saptanmıştır. Katılımcıların ortalaması 64,6±4,4 yıl olup, %89'u ayaktan almıştır. İzmir gibi metropol şehirlerden gelen hastalarda yatarak oranı yüksektir. En sık görülen fiziksel komorbiditeler hipertansiyon (%51,6) malnütrisyon (%31,4), psikiyatrik ise depresyon (%19,8) demans/bilişsel bozukluk (%17,3) belirlenmiştir. Sonuç: Geriatrik AKB, ciddi psikososyal eş tanılarla birlikte seyretmektedir. durum, erken tanının, disiplinler arası yaklaşımın kapsamla destek hizmetlerinin önemini vurgulamaktadır. Gelecek çalışmalar, yaşlı AKB'ye yönelik farkındalığı artırmayı bütüncül müdahale stratejileri geliştirmeyi hedeflemelidir.

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Exploring the Bone–Liver Axis: Impact of Acute Ethanol Intoxication on Post-Traumatic Liver Inflammation and Damage Following Femur Fracture

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4923 - 4923

Published: May 21, 2025

Bone fracture activates the immune system and induces inflammation crucial for healing but may also affect trauma-distant organs like liver. Acute alcohol intoxication (AAI) dysregulates responses affects organ damage post-trauma. However, bone–liver axis alcohol’s role in this process remain poorly understood. This study explores liver following fracture, with without prior AAI. Twenty-four male C57BL/6J mice were randomly assigned to four groups (n = 6) received either NaCl (control) or 35% ethanol via gavage. Mice underwent femur osteotomy external fixation sham surgery. After 24 h, was assessed using hematoxylin–eosin activated caspase-3 staining. Liver evaluated through CXCL1 polymorphonuclear leukocyte (PMNL) immunostaining, cytokine gene protein expression analyses, cell profiling flow cytometry. Western blotting NF-κB Wnt signaling. Neither alone nor AAI caused significant damage. significantly increased PMNL infiltration altered monocyte populations, effects that amplified by The hepatic neutrophil-to-monocyte ratio decreased after absent group. post-fracture, while MCP-1 IL-10 significantly, further amplifying these changes. Wnt1 Wnt3a levels strongly elevated completely abolished fracture-induced β-catenin reduction its phosphorylation, potentially involve an AAI-induced stabilization as well degradation. activation decreased, A20 Fracture influences inflammatory response signaling pathways, which modulated

Language: Английский

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