Strategic interventions in clinical randomized trials for metabolic dysfunction-associated steatotic liver disease (MASLD) and obesity in the pediatric population: a systematic review with meta-analysis and bibliometric analysis

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 21, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty (NAFLD), is a prevalent hepatic condition linked to metabolic alterations. It gradually causes damage and potentially progresses cirrhosis. Despite its significance, research, especially in the pediatric population, limited, leading contradictory findings diagnosis treatment. This meta-analysis aims synthesize existing literature on therapeutic interventions for MASLD children adolescents. A comprehensive search of randomized controlled clinical trials yielded 634 entries from PubMed, Scopus, Web Science up 2023. Interventions included medications, behavioral modifications, dietary changes, probiotics, supplements, surgical procedures, or combinations. The analysis focused studies with treatment duration at least 3 months, employing random-effects REML model. Treatment effects anthropometric measurements biochemical components were examined adjusted heterogeneity factors analysis. bibliometric insights into research contributors was performed. systematic review incorporated 31 trials, 24 meeting criteria meta-analysis. These comprised medication studies, 20 4 focusing lifestyle, centered diets. Significant overall observed ALT, AST, BMI, HOMA-IR mainly by supplements lifestyle. Meta-regression identified age, BMI modifying ALT concentrations. Bibliometric involving highlighted contributions 13 countries, USA, Spain, Chile being most influential. We conclude that supplementation lifestyle changes can effectively impact AST levels, which help address issues obese children. However, evaluation risk bias, high heterogeneity, emphasize need more high-quality broader inclusion diverse child populations provide better recommendations. PROSPERO, CRD42023393952. Registered January 25,

Language: Английский

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Effects of lifestyle-based interventions to improve Mediterranean diet adherence among the young population: a meta-analysis of randomized controlled trials

Nutrition Reviews, Journal Year: 2023, Volume and Issue: 82(7), P. 849 - 860

Published: Sept. 6, 2023

Abstract Context Despite the large number of studies published to date, effect lifestyle-based interventions on improving adherence Mediterranean diet (MedDiet) in young people has not been meta-analyzed. Objective The aim present systematic review and meta-analysis was two-fold: (1) determine pooled intervention effects MedDiet a population aged 3 years–18 years (2) examine potential factors related those effects. Data Sources A search MEDLINE (via PubMed), Scopus, Cochrane Library, Web Science databases performed from their inception until June 15, 2023. Extraction Different meta-analyses were independently observe (according Diet Quality Index children adolescents [KIDMED]). Analysis Compared with control group, group showed small increase KIDMED score (d = .27; 95% confidence interval [CI], .11 .43; P < .001; I2 89.7%). Similarly, participants groups had 14% higher probability achieving optimal (risk difference .14; CI, .02 .26; .023; 96.8%). Greater improvements found delivered out school .24, .04 .44; 88.4%), aimed at parents or both .20, .07 .34; 98.2%), including only overweight/obesity .34, .15 .52; .0%). Conclusion Healthy seem be effective increasing this dietary pattern among adolescents. Systematic Review Registration PROSPERO registration no. CRD2022369409.

Language: Английский

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Evaluation of the Relationships Among Mindful Eating, Environmental Beliefs, Adherence to the Mediterranean Diet, and Obesity in Children

Turkish Archives of Pediatrics, Journal Year: 2024, Volume and Issue: 59(1), P. 98 - 105

Published: Jan. 2, 2024

This study aimed to evaluate the relationship between adherence Mediterranean diet (MD), mindful eating, environmental beliefs, and obesity in children.

Language: Английский

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Meeting the 24-h movement recommendations and its relationship with Mediterranean dietary patterns in early childhood: the SENDO project

European Journal of Pediatrics, Journal Year: 2024, Volume and Issue: 183(5), P. 2365 - 2373

Published: March 2, 2024

Abstract The aim of this study was twofold: (1) to assess the association between meeting all three 24-h movement recommendations and adherence Mediterranean diet (MedDiet) in early childhood (2) examine whether participants who meet have greater individual MedDiet foods/components than those do not these recommendations. A cross-sectional conducted using a sample 822 from Seguimiento del Niño para un Desarrollo Óptimo (SENDO) project (Pamplona, Spain). Physical activity assessed through questionnaire that covered 17 different types activities. Screen time by averaging daily hours spent on activities such as watching TV, computer, or playing video games. Sleep duration determined taking average sleep durations during both weekdays weekends. Adherence evaluated Diet Quality Index children adolescents (KIDMED). Greater odds having an optimal were found for (odds ratio (OR) = 1.96, 95% confidence interval (CI) 1.33–2.87, p 0.001) comparison with their counterparts Specifically, significant differences “fruit fruit juice every day” ( 0.012), “second 0.001), “fresh cooked vegetables regularly once 0.018) relation recommendation status. Conclusions : This provides further evidence potential importance adopt healthier eating pattern. What is Known: • Only limited number studies investigated joint connection dietary habits. Integrating could potentially yield effectiveness compared promoting independently within public health strategies. New: first assessing relationship childhood. These findings provide

Language: Английский

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Inappropriate Diet Exacerbates Metabolic Dysfunction-Associated Steatotic Liver Disease via Abdominal Obesity

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4208 - 4208

Published: Dec. 5, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a refined categorization of non-alcoholic fatty (NAFLD), highlighting the intricate relationship between hepatic steatosis and metabolic dysfunction. Abdominal obesity (AO), key diagnostic criterion for dysfunction, predominantly results from inappropriate diet unhealthy dietary habits. To comprehensively investigate which factors contribute to MASLD through AO understand underlying biological mechanisms, we initially conducted systematic review meta-analysis articles in PubMed database past decade, summarizing that affect AO. Subsequently, targeted searches these provided narrative mechanisms how lead exacerbates MASLD. A characterized by excessive intake energy, carbohydrates, fructose, or ultra-processed foods (UPFs) is considered inappropriate. Inappropriate leads formation enhancing pathways such as de novo lipid synthesis (DNL) liver, insulin resistance (IR), gut-liver inflammation. Dietary interventions diets can effectively intervene improve The mechanism on abdominal fat deposition energy activation enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) increase endocortisol secretion. Then, accumulation visceral facilitates rapid augmented flux free acids (FFAs) initiates series deleterious effects, including oxidative stress (OS), endoplasmic reticulum (ERS), protein kinase C (PKC) pathways, Additionally, FFAs may mediate hepatocellular damage action hormones. These exacerbate progression steatohepatitis (MASH) fibrosis. Furthermore, investigating other potential influence could offer new recommendations treatment guidelines

Language: Английский

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