Advances in Nutrition, Journal Year: 2023, Volume and Issue: 15(1), P. 100151 - 100151
Published: Nov. 17, 2023
Language: Английский
JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(1), P. e2453332 - e2453332
Published: Jan. 7, 2025
Importance The association between maternal medications and the macronutrient composition of human milk has not been studied. Objective To compare levels in samples from mothers treated with long-term untreated healthy disease-matched control (DMCs). Design, Setting, Participants A cross-sectional study using collected October 2014 January 2024 breastfeeding US Canada invited to participate Mommy’s Milk Human Research Biorepository at University California, San Diego. Of 3974 unique individuals biorepository, 310 were 1 4 categories medications, 151 DMCs same underlying disorders, 73 mothers, frequency matched on infant age sex. these, 150 excluded because they had more than medication exposure or outliers. Data analyzed March June 2024. Exposures Continuous treatment selective serotonin reuptake inhibitors (SSRIs), monoclonal antibodies (MABs), systemic steroids, other anti-inflammatory drugs (ADs) 14 days before sample collection. Main Outcomes Measures Levels protein, fat, carbohydrate, total energy measured SpectraStar 2400 near infrared analyzer compared across groups analysis covariance adjusted for age, parity, body mass index, sex, exclusive breastfeeding, feeding frequency, collection time, cannabis use, occupation. Results 384 collected; 194 infants (50.5%) female; mean (SD) cohort was 33.5 (4.4) years, 6.6 (5.4) months. Mean protein 15% 21% lower exposed (0.92 [0.56] g/100 mL 63 SSRIs, 0.85 [0.51] MABs, 0.88 [0.37] 33 [0.54] 20 ADs) 64 (1.08 [0.50] mL). Adjusted differences significant SSRIs steroids ( F 1, 91 = 4.32; P .04 1,59 5.00, 0.03, respectively). fat 10% 22% ADs (3.40 [1.21] 69.56 [15.35] kcal/100 energy) (3.85 [1.66] 77.16 [22.08] DMC (4.38 [1.90] 80.60 [24.70] mothers. only 1,88 6.22; .01). Conclusions Relevance In this study, some associated milk, which could impose health risks breastfed infants. Other factors that influence need be clarified clinical implications these findings can confirmed.
Language: Английский
Citations
2
Advances in Nutrition, Journal Year: 2023, Volume and Issue: 15(1), P. 100127 - 100127
Published: Oct. 5, 2023
Human milk (HM) contains macronutrients, micronutrients, and a multitude of other bioactive factors, which can have long-term impact on infant growth development. We systematically searched MEDLINE, EMBASE, Cochrane Library, Scopus, Web Science to synthesize evidence published between 1980 2022 HM components anthropometry through 2 y age among term-born infants. From 9992 abstracts screened, 141 articles were included categorized based their reporting or components. Bioactives including hormones, oligosaccharides (HMOs), immunomodulatory are reported here, 75 from 69 unique studies observations 9980 dyads. Research designs, collection strategies, sampling times, geographic socioeconomic settings, practices, outcomes varied considerably. Meta-analyses not possible because data times inconsistent the included. Few measured intake, adjusted for confounders, precisely captured breastfeeding exclusivity, adequately described protocols. Only 5 (6%) had high overall quality scores. Hormones most extensively examined with 46 (n = 6773 dyads), compared 13 2640 dyads) HMOs 12 1422 Two conducted untargeted metabolomics. Leptin adiponectin demonstrated inverse associations growth, although several found no associations. No consistent individual outcomes. Among in HM, IL-6 relationships growth. Current research bioactives is largely inconclusive insufficient address complex composition HM. Future should ideally capture use biologically relevant anthropometrics, integrate across categories, embracing systems biology approach better understand how work independently synergistically influence
Language: Английский
Citations
25
Published: Jan. 22, 2025
Language: Английский
Citations
0
The Journal of Perinatal & Neonatal Nursing, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 3, 2025
The aim of the study is to determine effect macronutrient content breast milk on anthropometric measurements infants in first 6 months. Breast contains essential macro- and micronutrients needed early stages an infant's development. Current literature highlights importance understanding how milk's influences infant growth. protocol has been published PROSPERO (CRD42023425550). This adheres Preferred Reporting Items for Systematic Review Meta-Analysis Protocols (PRISMA-P) guideline. Studies between January 1, 2016, June 2, 2023, were reviewed across databases. Joanna Briggs Institute Cohort checklist was used assess methodological quality. Effect sizes calculated using both fixed-effects random-effects models. Six studies included systematic review meta-analysis. meta-analysis indicated a significant relationship lactose weight gain, length growth, head circumference, as well fat-lipid gain within months (P < .05). No found protein or carbohydrate > findings suggest that concentrations are important determinants Further research with high level evidence standard protocols recommended elucidate relationships
Language: Английский
Citations
0
Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
Purpose of review: Human milk is the optimal food choice for infants. Reviewing latest advances in research about human compounds and their effect on health helps understand benefits breastfeeding improves knowledge key bioactive nutrients that can be used to improve feeding during infancy, with short long-time effects health. Recent findings: In last years, it has been described how such as oligosaccharides, hormones, lipids, cellular components microbes play an important role infants’ health, reducing risk infectious, metabolic autoimmune diseases. The mechanisms transmission from mother infant these are not always well described, but there several lines biological beneficial effects. Summary: These findings may help maternal interventions, modifiable factors able modulate composition. They development formulas enhance nutritional plans. Also, identification isolation describe new ways supplementation.
Language: Английский
Citations
0
Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14
Published: Feb. 27, 2025
Lactose, commonly known as "milk sugar," offers various health benefits beyond its role an energy source. As a precursor for essential molecules, lactose impacts calcium absorption, has low cariogenicity, affects satiety, enhances athletic performance, and potentially functions prebiotic gut health. However, not all individuals can digest lactose, with minority of the population exhibiting gastrointestinal symptoms after consumption. The ability to during adulthood is genetically conferred trait lactase persistence, which also likely affected by epigenetic alterations other endogenous factors. In present review, we highlight multifaceted effects including impact on in satiety control, enhance potential Since these are inherently dependent intake trends digestion capacity populations, latest available information current consumption around world. Overall, gathered evidence suggests that moderate recommended, it foster multiple lifelong benefits.
Language: Английский
Citations
0
Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 112739 - 112739
Published: March 1, 2025
Adiposity rebound (AR) corresponds to the start of second rise in body mass index curve during infant growth. Early AR (before age 5) confers increased risk adiposity and metabolic disorders but is less likely occur breastfed infants. Although lipids breast milk are important child growth, information limited regarding which involved AR. The object this study was explore association between status children. We designed a case-control 184 mother-child pairs (AR cases: n = 93; controls: 91) included from Tohoku Medical Megabank Project Birth Three-Generation Cohort Study. Breast collected 1 month postpartum comprehensive lipid analysis performed. Partial least square-discriminant used candidate lipids, multivariable logistic regression evaluate associations with detected 667 molecules 12 classes milk. revealed fatty acid-hydroxy acid (FAHFA) cholesterol ester (ChE) status. Multivariable showed that exclusive breastfeeding at postpartum, FAHFA (odds ratio 1.57 [95% confidence interval, 1.06-2.32]) positively associated early AR, ChE 0.55 0.36-0.86]) negatively associated. (FAHFA, ChE) children, indicating potential regulate child's possible adulthood.
Language: Английский
Citations
0
Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113556 - 113556
Published: April 1, 2025
Language: Английский
Citations
0
Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 331 - 331
Published: Jan. 23, 2024
Limited attention is given to the efficacy of protocols for estimation infant intake milk components when investigating their impact on outcomes. We compared actual measured human with estimations derived from 15 determine most reliable approach estimating HM leptin, adiponectin, insulin, glucose, and total lipid. Twenty mothers who were 3–5 months postpartum completed a 24 h profile study pre-/post-feed samples collection. The true (control group) based (MI) was estimated intakes using concentrations five sampling that multiplied by one MI, considered mean MI (800 mL), or global (766 mL). six (three sets pre- post-feed samples, morning (06:00–09:00), afternoon (13:00–16:00), evening (19:00–22:00)) produced accurate estimates these components. Therefore, in absence measurements sampling, protocol comprising three provides
Language: Английский
Citations
2
International Breastfeeding Journal, Journal Year: 2024, Volume and Issue: 19(1)
Published: June 28, 2024
Abstract Background Despite global public health organizations endorsing breastfeeding or human milk (HM) as the optimal source of nutrition for infants, detailed knowledge how HM composition influences infant growth is lacking. In this commentary we summarize and interpret key findings a large systematic review on components child (N = 141 articles included). We highlight most consistent associations, discuss study quality issues, explore socio-economic time trends in body research, identify gaps future research directions. Key Findings Systematic Review grouped into three categories: micronutrients (28 articles), macronutrients (57 bioactives (75 articles). Overall, struggled to find associations between growth. The majority studies (85%) were moderate low-quality, with inconsistent collection analysis strategies being identified substantial concerns. Additional issues included failing account potential confounding by factors such exclusivity maternal mass index. Considerations Future Human Milk Research Many opportunities exist research. Using untargeted metabolomics will expand our understanding beyond previously defined well-understood components. Machine learning allow researchers investigate an integrated system, rather than individual should incorporate evidence-based sampling encompass circadian variation well consumption. Additionally, need focus developing high data using metrics definitions. Building multidisciplinary teams help ensure that outcomes are meaningful clinically relevant. Conclusion literature, there limited evidence relationship engage more accurate data, use standardized employ assays validated HM. By systematically evaluating existing literature identifying methods practice, hope inspire reporting guidelines support robust examining relationships
Language: Английский
Citations
2