Short-Chain Fatty Acids: Promising Therapeutic Targets for Respiratory Syncytial Virus Infection

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Jan. 28, 2025

Language: Английский

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Breastfeeding and Lung Function of Children: A Systematic Review and Meta‐Analysis

Journal of Paediatrics and Child Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

ABSTRACT Aim To evaluate the associations between breastfeeding and lung function among children without known respiratory diseases to determine effects of on spirometry. Methods A systematic search PubMed, Embase Cochrane was performed from their inception 11 Oct 2023 (PROSPERO identifier: CRD42023471664). Observational studies (cohort or cross‐sectional case–control design) randomised controlled trials (RCTs) were searched. random‐effects model meta‐analysis used estimate effect size if significant heterogeneity detected ( p < 0.05 I 2 > 50%); Otherwise, fixed‐effects applied. Results In total, 13 observational with 18 152 included in qualitative synthesis, five 5305 meta‐analysis. Compared who never breastfed, those breastfed had better FEV1 β : 19.34 mL; 95% CI: 6.05, 32.64; = 0.004) PEF 87.50 mL/s; 27.43, 147.58; 0.004). similar trend observed for FVC 17.45 −0.43, 35.33; 0.06). Furthermore, compared less than three four months, months more 19.86 4.21, 35.51; 0.01), 31.90 7.87, 55.93; 0.009) 75.68 24.40, 126.97; Conclusion This review revealed improved aged 6–16 years. Further high‐quality evidence is needed.

Language: Английский

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Bioactive compounds in human milk

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Purpose of review: Human milk is the optimal food choice for infants. Reviewing latest advances in research about human compounds and their effect on health helps understand benefits breastfeeding improves knowledge key bioactive nutrients that can be used to improve feeding during infancy, with short long-time effects health. Recent findings: In last years, it has been described how such as oligosaccharides, hormones, lipids, cellular components microbes play an important role infants’ health, reducing risk infectious, metabolic autoimmune diseases. The mechanisms transmission from mother infant these are not always well described, but there several lines biological beneficial effects. Summary: These findings may help maternal interventions, modifiable factors able modulate composition. They development formulas enhance nutritional plans. Also, identification isolation describe new ways supplementation.

Language: Английский

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Call to include breastfeeding as a synergistic approach to vaccines for prevention of respiratory syncytial virus disease

International Breastfeeding Journal, Journal Year: 2025, Volume and Issue: 20(1)

Published: March 3, 2025

Abstract Background Infections with respiratory syncytial virus (RSV) in infancy and early childhood are very common. RSV is the leading cause of bronchiolitis pneumonia substantially contributes to morbidity mortality infants young children worldwide. Until recently, there have been no vaccines available for prevention curative treatments RSV. Two novel pharmaceutical approaches became 2024 namely immunization mothers during pregnancy immunoprophylaxis infants. Since then, a series scientific papers as well national international guidance published encourage parents vaccinate themselves or their children. Despite strong evidence that breastfeeding an important non-pharmacological approach severe outcomes, recent public health communications neglected core RSV-preventive strategy. This commentary highlights epidemiological protective effects key intervention, discussing its synergistic role supportive care sick Breastfeeding has shown reduce rate severity RSV-associated including hospitalization mortality. While exclusive most protective, even one month was associated reduced likelihood Intensive Care Unit admission need mechanical ventilation RSV-infected The benefits demonstrated studies low-, middle- high-income settings especially small, premature Conclusion overlooked sustainable strategy universal outcomes serves disease infancy, vulnerable population groups. should be encouraged alongside all communication, by providers pre- postnatal visits infant check-ups. Further, critically-ill not overlooked.

Language: Английский

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Human milk oligosaccharide secretion dynamics during breastfeeding and its antimicrobial role: A systematic review

World Journal of Clinical Pediatrics, Journal Year: 2025, Volume and Issue: 14(2)

Published: March 18, 2025

BACKGROUND Human milk oligosaccharides (HMOs) are bioactive components of breast with diverse health benefits, including shaping the gut microbiota, modulating immune system, and protecting against infections. HMOs exhibit dynamic secretion patterns during lactation, influenced by maternal genetics environmental factors. Their direct indirect antimicrobial properties have garnered significant research interest. However, a comprehensive understanding dynamics their correlation efficacy remains underexplored. AIM To synthesize current evidence on lactation evaluate roles bacterial, viral, protozoal pathogens. METHODS A systematic search PubMed, Scopus, Web Science, Cochrane Library focused studies investigating natural synthetic HMOs, dynamics, properties. Studies involving human, animal, in vitro models were included. Data HMO composition, temporal patterns, mechanisms action extracted. Quality assessment was performed using validated tools appropriate for study design. RESULTS total 44 included, encompassing research. exhibited 2′-fucosyllactose (2′-FL) lacto-N-tetraose peaking early declining over time, while 3-fucosyllactose (3-FL) increased later stages. demonstrated through pathogen adhesion inhibition, biofilm disruption, enzymatic activity impairment. Synthetic bioengineered 2′-FL 3-FL, structurally functionally comparable to effectively inhibiting pathogens such as Pseudomonas aeruginosa , Escherichia coli Campylobacter jejuni . Additionally, synergistic effects antibiotics, enhancing resistant CONCLUSION vital defense, supporting infant targeting various Both hold potential therapeutic applications, particularly nutrition adjuncts antibiotics. Further research, clinical trials, is essential address gaps knowledge, validate findings, explore broader applicability improving neonatal health.

Language: Английский

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Comprehensive review on human Milk oligosaccharides: Biosynthesis, structure, intestinal health benefits, immune regulation, neuromodulation mechanisms, and applications

Food Research International, Journal Year: 2025, Volume and Issue: 209, P. 116328 - 116328

Published: April 6, 2025

Language: Английский

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Effects of Different Feeding Patterns on the Gut Virome of 6‐Month‐Old Infants

Journal of Medical Virology, Journal Year: 2025, Volume and Issue: 97(4)

Published: April 1, 2025

ABSTRACT The gut microbiome is essential for infant health, and in recent years, the impact of enteroviruses on health disease has received increasing attention. transmission breast milk phages to gastrointestinal tract contributes shaping virome, while breastfeeding regulates colonization virome. In this study, we collected fecal samples from healthy infants analyzed distribution characteristics viral communities by metagenomic analysis, differences under different feeding practices. Our results indicate that intestinal virome consists eukaryotic viruses. Caudovirales Microviridae dominated phage composition, except Siphoviridae , which was more predominant intestines formula‐fed infants, there were no significant overall abundance other with patterns. Breastfeeding can lead a higher diversity viruses through vertical transmission, highly diverse helps maintain maturation microbiome. This study informs further research formation processes.

Language: Английский

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The changes in HMOs of GDM mothers over lactation: Regulation on the gut microbiota development in offspring

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104957 - 104957

Published: Aug. 20, 2024

Language: Английский

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