Prebiotics in food and dietary supplements: a roadmap to EU health claims DOI Creative Commons
Kieran Tuohy, Elaine E. Vaughan,

Lucien F. Harthoorn

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 15, 2024

Numerous studies have established that prebiotic ingredients in foods and dietary supplements may play a role supporting human health. Over the three decades passed since prebiotics were first defined as concept, research has revealed complex universe of prebiotic-induced changes to microbiota. There are strong indications direct link between these specific health benefits. However, at present time, EU not permitted use term 'prebiotic' connection with an approved claim. This paper is outcome workshop organized on 25th October 2023 by European branch International Life Science Institute (ILSI). It provides overview regulatory requirements for authorized claims EU, key areas research, findings date relation digestive, immune, metabolic cognitive Research gaps documentation challenges then explored roadmap proposed achieving authorization wording future claims.

Language: Английский

Cirsiliol Alleviates Experimental Inflammatory Bowel Disease via Restoration of Intestinal Barrier Integrity and Inhibition of NF-κB and MAPK Pathways DOI
Juan Gao, Haiyang Li, Zhenquan Wang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder characterized by intestinal inflammation and barrier dysfunction. This study investigated the therapeutic potential of Cirsiliol, natural flavonoid, in DNBS-induced murine colitis model..Mice were randomly divided into control, model, Cirsiliol treatment groups (10 mg/kg 30 mg/kg). Disease activity was assessed through body weight, colon length, index (DAI). Molecular mechanisms evaluated using immunohistochemistry, Western blot, biochemical assays. significantly ameliorated symptoms, reducing weight loss DAI scores while improving length. Mechanistically, suppressed pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), enhanced antioxidant defenses (increased GSH, decreased MDA), restored tight junction protein expression (Claudin-1, Occludin, E-cadherin). Furthermore, it modulated apoptosis-related proteins (reduced Bax, Caspase-3; increased Bcl-2) promoted epithelial migration.

Language: Английский

Citations

0
Prebiotics in food and dietary supplements: a roadmap to EU health claims DOI Creative Commons
Kieran Tuohy, Elaine E. Vaughan,

Lucien F. Harthoorn

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 15, 2024

Numerous studies have established that prebiotic ingredients in foods and dietary supplements may play a role supporting human health. Over the three decades passed since prebiotics were first defined as concept, research has revealed complex universe of prebiotic-induced changes to microbiota. There are strong indications direct link between these specific health benefits. However, at present time, EU not permitted use term 'prebiotic' connection with an approved claim. This paper is outcome workshop organized on 25th October 2023 by European branch International Life Science Institute (ILSI). It provides overview regulatory requirements for authorized claims EU, key areas research, findings date relation digestive, immune, metabolic cognitive Research gaps documentation challenges then explored roadmap proposed achieving authorization wording future claims.

Language: Английский

Citations

0