The intensity of the transcriptional response varies across infection with distinct viral strains in an insect host

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 21, 2025

Abstract Organisms respond to infectious agents through diverse immune strategies, and may need cater a specific response distinct pathogen challenges, such as various strains of virus, maximize fitness. Deformed wing virus (DWV) is one the most damaging viruses honey bees ( Apis mellifera ) across globe, with variant DWV-B currently expanding at expense DWV-A. While previous research has characterized general host transcriptomic responses viral exposure, different DWV have not been fully explored. Here, we performed experimental infections two dominant DWV, A B, well mixed infection, conducted analyses compare differences in molecular infection. We confirmed canonical anti-viral including upregulation Toll pathway genes antimicrobial peptides abaecin hymenoptaecin. Furthermore, our results suggest potential role aerobic glycolysis during infection bees. DWV-A were associated differential expression much larger number than DWV-B. That potentially elicits reduced provide mechanistic explanation for its higher virulence global emergence. Overall, this study provides first evidence strain-specific integrates these findings into broader domain insect immunity host-pathogen dynamics.

Language: Английский

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Co-exposure to a honeybee pathogen and an insecticide: synergistic effects in a new solitary bee host but not in Apis mellifera

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 292(2042)

Published: March 1, 2025

Pesticides and pathogens are major drivers of bee declines. However, their potential interactions poorly understood, especially for non-Apis bees. This study assessed the combined effects infestation by honeybee pathogen Vairimorpha ceranae chronic exposure to insecticide flupyradifurone on Osmia bicornis Apis mellifera. We investigated whether V. could reproduce in a new solitary host (O. bicornis) sublethal lethal pesticide, alone combination. also analysed interactive proliferation survival two species. Newly emerged bees were orally infected with 100 000 spores then exposed ad libitum at field-realistic concentrations. showed, first time our knowledge, that can replicate midgut O. bicornis, causing histological damage, impaired phototactic response, reduced food consumption decreased longevity. The pathogen-pesticide combination caused synergistic effect leading an abrupt decline. In A. mellifera, showed antagonistic effects, but pesticide promoted proliferation. Our results warn against spillover multiple stressor

Language: Английский

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Uptrend in global managed honey bee colonies and production based on a six-decade viewpoint, 1961–2017

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Dec. 9, 2022

We conducted a retrospective study to examine the long-term trends for global honey bee population and its two main products: beeswax. Our analysis was based on data collected by Food Agriculture Organization of United Nations from 1961 2017. During this period, there were increases in number managed colonies (85.0%), production (181.0%) beeswax (116.0%). The amount produced per colony increased 45.0%, signifying improvements efficiency producing honey. Concurrently, human grew 144.0%. Whilst absolute globally, capita declined 19.9% 13.6 1000 10.9 Beeswax had similar trend as reduced 8.5% 8.2 7.5 kg population. In contrast, 42.9% at level. growth outpaced that colonies. Continuation raises possibility having shortfall pollinators meet increasing consumer demand pollinated crops. To mitigate these challenges locally driven solutions will be key influencing factors differed geographically.

Language: Английский

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“Migratory beekeeping and its influence on the prevalence and dispersal of pathogens to managed and wild bees”

International Journal for Parasitology Parasites and Wildlife, Journal Year: 2022, Volume and Issue: 18, P. 184 - 193

Published: May 21, 2022

Demand for food is growing along with the human population, leading to an increase in plant production. Many crops are pollinated by insects, so global demand managed pollinators also increasing. The honey bee has traditionally been considered main provider of crop pollination services. For providing it beekeepers seasonally transport hives different locations after flowering crops. These movements could be detrimental by: i) stressing bees, making them more susceptible pathogens and parasites; ii) spreading parasites across locations; iii) increasing transmission between wild vice versa (spillover spillback, respectively). To understand impact migratory beekeeping on health, we conducted a systematic review identify trends provide complete picture existing knowledge subject. We found 52 studies analysing pathogen-related impacts bees. However, only 16 investigations tested effect practices prevalence spread parasites. no that assessed occurrence pests diseases In general, tends colonies. results were very heterogeneous, probably due several uncontrolled underlying factors such as management, biological geographical factors, interactions them. conclusion, there urgent need assess given current decline expected climate change demand.

Language: Английский

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Trace metals with heavy consequences on bees: A comprehensive review

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 895, P. 165084 - 165084

Published: June 26, 2023

Language: Английский

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Herbaceous Alfalfa plant as a multipurpose crop and predominant forage specie in Pakistan

Frontiers in Sustainable Food Systems, Journal Year: 2023, Volume and Issue: 7

Published: March 6, 2023

Fodder crops play an important role in agriculture as they deliver food for animals, which is eventually converted to humans. All over the world, Alfalfa has had utmost importance a few decades, not only fodder crop due having high nutritional value dairy farming but also being positively involved many health-related and environmental affairs. Medicinally, it helps controlling diseases such arthritis, cholesterol, anemia, cardio-related illnesses. Furthermore, like other cereal (wheat, rice, corn, etc.), could be great source of several healthy nutrients humans when proper quantity added daily meals. However, unlike nations world America, China, India, Pakistan does utilize directly human This eco-friendly behavior since controls soil erosion by binding particles together makes atmospheric nitrogen available plants fixing soil. Other uses include its water purification, improved pollination, most importantly, tolerance against water, salt, temperature stress, making position even stronger arid semi-arid areas. review will draw researchers' attention multiple than availability at very low cost, prove nothing short miracle economy if properly mediated.

Language: Английский

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Enhancing knowledge of chemical exposures and fate in honey bee hives: Insights from colony structure and interactions

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 916, P. 170193 - 170193

Published: Jan. 25, 2024

Honey bees are unintentionally exposed to a wide range of chemicals through various routes in their natural environment, yet research on the cumulative effects multi-chemical and sublethal exposures important caste members, including queen bee brood, is still its infancy. The hive's social structure food-sharing (trophallaxis) practices aspects consider when identifying primary secondary exposure pathways for residential hive members possible chemical reservoirs within colony. Secondary may also occur transfer (maternal offloading) brood by contact diffusion from wax cells all members. lack peer-to-peer contaminants metabolites be part due limitations sensitive analytical techniques monitoring fate dispersion. Combined application automated honey modern trace analysis could offer rapid progress quantifying accumulation environment developing effective mitigation strategies toxic co-exposures. To enhance understanding toxicity entire colony, it crucial both intricate interactions among potential synergistic arising combinations metabolites.

Language: Английский

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Contaminant dynamics in honey bees and hive products of apiaries from environmentally contrasting Argentinean regions

Environmental Research, Journal Year: 2024, Volume and Issue: 249, P. 118306 - 118306

Published: Feb. 1, 2024

Language: Английский

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Experimental cross species transmission of a major viral pathogen in bees is predominantly from honeybees to bumblebees

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2022, Volume and Issue: 289(1969)

Published: Feb. 16, 2022

Cross-species transmission of a pathogen from reservoir to recipient host species, spillover, can have major impacts on biodiversity, domestic species and human health. Deformed wing virus (DWV) is panzootic RNA in honeybees that causal their elevated colony losses, several correlative field studies suggested spillover DWV managed wild bee such as bumblebees. Yet unequivocal demonstration lacking, while spillback, the back host, rarely considered. Here, we show fully crossed laboratory experiments (genotype A) bumblebees occurs readily, yet neither detected viral nor onward experimentally infected uninoculated Our results support potential for other when robbing resources heterospecific nests or visiting same flowers. They also underscore importance virulence so evaluate impact individual population fitness well adaption new species.

Language: Английский

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Toward evidence-based decision support systems to optimize pollination and yields in highbush blueberry

Frontiers in Sustainable Food Systems, Journal Year: 2022, Volume and Issue: 6

Published: Oct. 21, 2022

Highbush blueberry ( Vaccinium spp.) is a globally important fruit crop that depends on insect-mediated pollination to produce quality and commercially viable yields. Pollination success in complex impacted by multiple interacting factors including flower density, bee diversity abundance, weather conditions. Other factors, floral traits, economics also contribute at the farm level but are less well understood. As production continues expand globally, decision-aid technologies needed optimize enhance sustainability of strategies. The objective this review highlight our current knowledge about pollination, where research efforts focused, future should be directed successfully implement comprehensive decision-making framework for modern systems. Important gaps remain, how integrate wild managed pollinators provide predictable stable across variable environmental In addition, continued advances pesticide stewardship required pollinator health outcomes. Integration on- off-farm data, statistical models, software tools could distill scientific information into systems support sustainable, evidence-based decisions level. Utility these will require multi-disciplinary strategic deployment through effective extension information-sharing networks growers, beekeepers, extension/crop advisors.

Language: Английский

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