Long-term iodine deficiency and excess inhibit β-casein and α-lactalbumin secretion of milk in lactating rats DOI

Ying Zhang,

Xin Zhao, Na Zhao

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2024, Volume and Issue: unknown, P. 109812 - 109812

Published: Nov. 1, 2024

Language: Английский

Comparative proteomic analysis of human milk fat globules and paired membranes and mouse milk fat globules identifies core cellular systems contributing to mammary lipid trafficking and secretion DOI Creative Commons
Jayne F. Martin Carli, Monika Dzieciątkowska, Teri L. Hernandez

et al.

Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10

Published: Dec. 18, 2023

Introduction: Human milk delivers critical nutritional and immunological support to human infants. Milk fat globules (MFGs) their associated membranes (MFGMs) contain the majority of lipids many bioactive components that contribute neonatal development health, yet compositions have not been fully defined, mechanisms responsible for formation these structures remain incompletely understood. Methods: In this study, we used untargeted mass spectrometry quantitatively profile protein freshly obtained MFGs paired, physically separated MFGM fractions from 13 samples. We also profiled MFG 9 pooled samples 18 lactating mouse dams. Results: identified 2,453 proteins 2,795 in samples, respectively, 1,577 MFGs. Using paired analyses abundance MFGMs compared (MFGM-MFG; 1% FDR), 699 were more highly abundant (MFGM-enriched), 201 less (cytoplasmic). MFGM-enriched comprised membrane systems (apical plasma multiple vesicular membranes) hypothesized be lipid secretion transport signaling systems. Cytoplasmic included ribosomal proteasomal Comparing between MFGs, found a positive correlation ( R 2 = 0.44, p < 0.0001) relative abundances 1,279 common across species. Discussion: Comparative pathway enrichment reveal similarities trafficking pathways involved identify potentially novel Our results advance knowledge composition quantities greater detail, provide quantitative specifically enriched proteins, core cellular secretion.

Language: Английский

Citations

4
Delivering on the Promise of Human Milk for Extremely Preterm Infants in the NICU DOI
Mandy B. Belfort, Maryanne T. Perrin

JAMA, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 30, 2024

Our website uses cookies to enhance your experience. By continuing use our site, or clicking "Continue," you are agreeing Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals Network Open Cardiology Dermatology Health Forum Internal Medicine Neurology Oncology Ophthalmology Otolaryngology–Head & Neck Surgery Pediatrics Psychiatry Archives of (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions LibrariansReprints Permissions Terms Use Privacy Accessibility Statement 2024 American Association. All Rights Reserved Search Archive Input Term Sign In Individual inCreate an Account Access through institution Purchase Options: Buy this article Rent Subscribe the journal

Language: Английский

Citations

1
Associations of Dietary Intake and Nutrient Status with Micronutrient and Lipid Composition in Breast Milk of Donor Women DOI Open Access
Noelia Ureta-Velasco, A Montealegre,

Kristin Keller

et al.

Published: June 28, 2023

The influence of diet and nutritional status milk donors on the composition donor human (DHM) is unknown. present study aimed to determine profile DHM associations donors’ dietary intake with micronutrient lipid in DHM. For this purpose, 113 completed a food frequency questionnaire, provided 5-day weighed record, collected for 5 consecutive days. Nutrient determinations erythrocytes, plasma, urine, were performed. Multiple linear regressions conducted evaluation associations. We highlight following results: docosahexaenoic acid (DHA) was positively associated plasma DHA content (R2 0.45, p < 0.001). every 1 g/day intake, percentage increased by 0.38% (% total fat) omega-3 0.78% 0.29, saturated fatty acids erythrocyte dimethyl acetals, stearic acid, trans breastfeeding duration, negatively margaroleic 0.34, 0.01). cholecalciferol levels dairy 0.57, Other weaker found free thiamine, riboflavin, pyridoxal, dehydroascorbic In conclusion, influences

Language: Английский

Citations

3
Associations of Dietary Intake and Nutrient Status with Micronutrient and Lipid Composition in Breast Milk of Donor Women DOI Open Access
Noelia Ureta-Velasco, A Montealegre,

Kristin Keller

et al.

Published: July 25, 2023

The influence of diet and nutritional status milk donors on the composition donor human (DHM) is unknown. present study aimed to determine profile DHM associations donors’ dietary intake with micronutrient lipid in DHM. For this purpose, 113 completed a food frequency questionnaire, provided 5-day weighed record, collected for 5 consecutive days. Nutrient determinations erythrocytes, plasma, urine, were performed. Multiple linear regressions conducted evaluation associations. We highlight following results: docosahexaenoic acid (DHA) was positively associated plasma DHA content (R2 0.45, p < 0.001). every 1 g/day intake, percentage increased by 0.38% (% total fat) omega-3 0.78% 0.29, saturated fatty acids erythrocyte dimethyl acetals, stearic acid, trans breastfeeding duration, negatively margaroleic 0.34, 0.01). cholecalciferol levels dairy 0.57, Other weaker found free thiamine, riboflavin, pyridoxal, dehydroascorbic In conclusion, influences

Language: Английский

Citations

1
Long-term iodine deficiency and excess inhibit β-casein and α-lactalbumin secretion of milk in lactating rats DOI

Ying Zhang,

Xin Zhao, Na Zhao

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2024, Volume and Issue: unknown, P. 109812 - 109812

Published: Nov. 1, 2024

Language: Английский

Citations

0