Incidence and factors influencing delayed onset of lactation: a systematic review and meta-analysis

International Breastfeeding Journal, Journal Year: 2024, Volume and Issue: 19(1)

Published: Aug. 22, 2024

Breastfeeding has many benefits for mothers and infants. Lactogenesis II is one of the key steps in implementation breastfeeding. If lactogenesis occurs more than 72 h after delivery, it termed delayed onset lactation (DOL). DOL associated with decreased milk production, shortened breastfeeding time, pathological neonatal weight loss. A comprehensive summary incidence factors influencing needed to provide a basis improving practices health outcomes. Studies on were retrieved from 13 Chinese English databases (PubMed, Embase, Web Science, Cochrane Library, CINAHL, etc.) database inception August 2023. Two researchers independently conducted study screening, data extraction quality evaluation. Stata 16.0 SE software was used analysis, sensitivity analysis publication bias tests also performed. The qualitative description method analyse studies that could not be combined quantitatively. total 35 involving 19,176 parturients, including 4,922 who had DOL, included. mean Newcastle‒Ottawa scale score included ≥ 6, indicating relatively high. Finally, 30%, robust results no obtained: prepregnancy body mass index (overweight or obesity), gestational diabetes, hypertension, thyroid disease during pregnancy, serum albumin levels (< g/L), parity, (unscheduled) caesarean section, section history, daily sleep duration, age, birth 2.5 kg), guidance frequency. However, there still six undetermined associations: gain, (≥ 4 anxiety, time first session (maternal separation) breast massage treatment. Clinicians should pay attention parturients at high risk formulate targeted prevention strategies according reduce occurrence promote better maternal infant PROSPERO (ID: CRD42023458786), September 10,

Language: Английский

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Sampling Procedures for Estimating the Infant Intake of Human Milk Leptin, Adiponectin, Insulin, Glucose, and Total Lipid

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 331 - 331

Published: Jan. 23, 2024

Limited attention is given to the efficacy of protocols for estimation infant intake milk components when investigating their impact on outcomes. We compared actual measured human with estimations derived from 15 determine most reliable approach estimating HM leptin, adiponectin, insulin, glucose, and total lipid. Twenty mothers who were 3–5 months postpartum completed a 24 h profile study pre-/post-feed samples collection. The true (control group) based (MI) was estimated intakes using concentrations five sampling that multiplied by one MI, considered mean MI (800 mL), or global (766 mL). six (three sets pre- post-feed samples, morning (06:00–09:00), afternoon (13:00–16:00), evening (19:00–22:00)) produced accurate estimates these components. Therefore, in absence measurements sampling, protocol comprising three provides

Language: Английский

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The Effect of Maternal Overweight/Obesity on Serum and Breastmilk Leptin, and Its Associations with Body Composition, Cardiometabolic Health Indices, and Maternal Diet: The BLOOM Study

Metabolites, Journal Year: 2024, Volume and Issue: 14(4), P. 221 - 221

Published: April 13, 2024

In overweight and obese patients, elevated serum breastmilk leptin concentrations are observed, with also being likely affected by the diet. We analyzed in normal weight (NW) overweight/obese (OW/OB) mothers, evaluated its associations (1) maternal anthropometric parameters; (2) markers of cardiometabolic health; (3) The BLOOM (Breastmilk Link to Overweight/Obesity Maternal diet) study was conducted among 40 women (n = 20 OW/OB; n 20, NW) who were exclusively or predominantly breastfeeding for 15.5 ± 1.2 (OW/OB group) weeks. collected 24 h fasting blood samples analysis ELISA. dietary habits using a 3-day record food frequency questionnaire, which used calculate Polish-adapted Mediterranean Diet score. measurements DEXA scans performed, indices calculated. OW mothers had 1.4 times higher levels, while OB 4.5 6.2 respectively, comparison NW mothers. FM% correlated levels (r 0.878, r 0.638). Serum associated health such as AIP, CMI, VAI LAP OW/OB Higher energy, fructose intake adherence diet (β 0.323, 0.039–0.608; β 0.318, 0.065–0.572; 0.279, 0.031–0.528); meanwhile, could protect against −0.444, −0.839–−0.050), even after adjustment FM%. Our results suggest potential association between health. addition, we confirm importance healthy patterns improvement composition.

Language: Английский

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The Influence of Maternal Lifestyle Factors on Human Breast Milk Microbial Composition: A Narrative Review

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2423 - 2423

Published: Oct. 22, 2024

Human breast milk (HBM) is considered the gold standard for infant nutrition due to its optimal nutrient profile and complex composition of cellular non-cellular components. Breastfeeding positively influences newborn's gut microbiota health, reducing risk conditions like gastrointestinal infections chronic diseases (e.g., allergies, asthma, diabetes, obesity). Research has revealed that HBM contains beneficial microbes aid maturation through mechanisms antimicrobial production pathogen exclusion. The can be affected by several factors, including gestational age, delivery mode, medical treatments, lactation stage, as well maternal lifestyle habits diet, physical activity, sleep quality, smoking, alcohol consumption, stress level). Particularly, factors play a significant role in shaping directly modulating microbial or influencing enteromammary pathway. This narrative review current findings summarized how microbiota. While influence diet on well-documented, indicating dietary patterns, especially those rich plant-based proteins carbohydrates, microbiota, impact other poorly investigated. Maintaining healthy during pregnancy breastfeeding crucial health both mother baby. Understanding colonization HBM, along with their interactions impact, key developing new strategies support infant's

Language: Английский

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Human Milk Nutrient Composition Data is Critically Lacking in the United States and Canada: Results from a Systematic Scoping Review of 2017–2022

Advances in Nutrition, Journal Year: 2023, Volume and Issue: 14(6), P. 1617 - 1632

Published: Sept. 25, 2023

Characterization of the nutrients in human milk is important to understand dietary and developmental requirements infants. The objective this review was summarize state-of-the-science on nutrient composition United States Canada published from 2017 2022. Four databases were searched for randomized controlled studies others given scoping nature review. We limited type mature collected 21 d postpartum beyond lactating individuals who gave birth at 37-wk gestation or later (full-term). Outcomes interest included traditional macro- micronutrients, including oligosaccharides (HMOs), volume. publication date range selected as January 1, 2017, day literature search performed. A total 32 articles primarily longitudinal cohort cross-sectional designs. most prevalent sample collection method full-breast expression (n = 20) with 26) collecting samples a single timepoint. Carbohydrates (HMOs [n 12], glucose 8], lactose 6]) protein 5) frequently assessed body work, consensus among that present concentrations compared (24-64 mg/dL 6-7 g/dL) HMOs are influenced by temporality secretor status. Included displayed an overall level heterogeneity sparsity paralleling previous reports data USDA FoodData Central system. Much extracted retained generally provided analysis specific group nutrients. Moreover, many did not use preferred analytical methods outlined Human Milk Composition Initiative increase measurement confidence. Up-to-date still greatly needed it paramount management infant feeding, assessment maternal nutritional health needs, reference formula development.

Language: Английский

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Early Pumping Behaviors Predict Pumped Milk Volume, Achievement of Secretory Activation and Coming to Volume in Breast Pump-Dependent Mothers of Preterm Infants

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 16, 2024

Objective: Pumping studies in mothers of preterm infants are limited by self-reported pumping behaviors and non-objective measures pumped milk volume secretory activation (SA). Study Design: Non-randomized observational study first 14 days postpartum 29 infants. Smart pumps measured stored volume. Selective ion electrodes sodium sodium:potassium ratio to determine SA. Generalized estimating equations, cluster analyses multivariate regression were used. Results: SA was delayed (median 5.8 days) impermanent. Each additional daily increased odds within 2 48% (p=.01). High-intensity (N=17) had greater cumulative than low-intensity (N=12). variables showed changes the week, then plateaued. Conclusion: The week is critical for optimizing behaviors. Accurate, objective behaviors, a research priority.

Language: Английский

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Early postpartum pumping behaviors, pumped milk volume, and achievement of secretory activation in breast pump-dependent mothers of preterm infants

Journal of Perinatology, Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

Language: Английский

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Comparative proteomic analysis of human milk fat globules and paired membranes and mouse milk fat globules identifies core cellular systems contributing to mammary lipid trafficking and secretion

Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10

Published: Dec. 18, 2023

Introduction: Human milk delivers critical nutritional and immunological support to human infants. Milk fat globules (MFGs) their associated membranes (MFGMs) contain the majority of lipids many bioactive components that contribute neonatal development health, yet compositions have not been fully defined, mechanisms responsible for formation these structures remain incompletely understood. Methods: In this study, we used untargeted mass spectrometry quantitatively profile protein freshly obtained MFGs paired, physically separated MFGM fractions from 13 samples. We also profiled MFG 9 pooled samples 18 lactating mouse dams. Results: identified 2,453 proteins 2,795 in samples, respectively, 1,577 MFGs. Using paired analyses abundance MFGMs compared (MFGM-MFG; 1% FDR), 699 were more highly abundant (MFGM-enriched), 201 less (cytoplasmic). MFGM-enriched comprised membrane systems (apical plasma multiple vesicular membranes) hypothesized be lipid secretion transport signaling systems. Cytoplasmic included ribosomal proteasomal Comparing between MFGs, found a positive correlation ( R 2 = 0.44, p &lt; 0.0001) relative abundances 1,279 common across species. Discussion: Comparative pathway enrichment reveal similarities trafficking pathways involved identify potentially novel Our results advance knowledge composition quantities greater detail, provide quantitative specifically enriched proteins, core cellular secretion.

Language: Английский

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Assessing Pregnant Women's Readiness for Pregnancy-Healthy Nutrition: A Trans-theoretical Model Approach

Mağallaẗ al-Mawṣil li-l-tamrīḍ/Mosul journal of nursing, Journal Year: 2024, Volume and Issue: 12(1), P. 84 - 91

Published: Jan. 12, 2024

Background: Pregnant women undergo significant physiological changes, requiring careful nutrition and lifestyle attention. This study explores the readiness of primiparous to adhere healthy during pregnancy, utilizing Trans-Theoretical Model Change (TTM) as a theoretical framework. Understanding various stages can inform tailored interventions support pregnant in adopting maintaining behavior.Methods: month-long Study conducted Maternity Hospitals Mosul City used descriptive, predictive correlational design. The sample included 300 selected from Al-Salam Teaching Hospital, El-Khansa Al-Batul Hospital. inclusion criteria covered primiparity gestational age between 13 35 weeks. Various instruments were used, including sociodemographic sheets scales for socioeconomic status, change, processes decisional balance, self-efficacy. Ethical considerations written verbal consent participants.Results: identified different phases among according TTM: pre-contemplation (15%), contemplation (22%), preparation (32%), action (28%), maintenance (3.3%). key constructs varied significantly these phases, with balance scores peaking phase, perceived benefits highest maintenance, barriers most contemplation. Self-efficacy showed levels phase. These findings underscore importance tailoring specific TTM promote behaviors enhance self-efficacy pregnancy.Conclusions: highlights relevance understanding women's adopt nutrition. Tailored corresponding each phase are crucial positive enhancing pregnancy. Healthcare providers should consider insights develop targeted strategies help adhering pregnancy-healthy guidelines.

Language: Английский

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Relationship between maternal biological features, environmental factors, and newborn neuromotor development associated with visual fixation abilities

Brain and Cognition, Journal Year: 2024, Volume and Issue: 180, P. 106202 - 106202

Published: July 10, 2024

Newborn visual fixation abilities predict future cognitive, perceptive, and motor skills. However, little is known about the factors associated with newborn fixation, which an indicator of neurocognitive abilities. We analyzed maternal biological environmental characteristics fine skills (visual tracking) in 1 month old infants. Fifty-one infants were tested on tracking tasks (Infant Visuomotor Behavior Assessment Scale/ Guide for Visual Ability Infants) classified according to conducts scores. Differences between groups compared considering development (Alberta Infant Motor Scale) mental health (Edinburgh Postnatal Depression Scale Hamilton Anxiety Scale); home environment (Affordances Home Environment Development care (Coding Interactive Behavior); breastmilk composition (total fatty acids, proteins, cortisol); metabolic profile (serum hormones interleukins). Mothers lower scores had higher levels protein at 3 months. better conduct serum T4 (at month) prolactin months). There no associations ability development, environment, or care. Early neuromotor especially skills, (metabolic composition), highlighting importance early detection changes healthy neurodevelopment newborns.

Language: Английский

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