Dietary protein requirements of older adults with sarcopenia determined by the indicator amino acid oxidation technology DOI Creative Commons
Wenxuan Wu,

Fengge Chen,

Hui Ma

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 28, 2025

Background Although protein supplementation may be desirable in the management of sarcopenia, appropriate requirements for older adults with sarcopenia are presently unclear. Objective The aim this study was to determine (65–81 year) by using indicator amino acid oxidation (IAAO) technology. Methods Nine (four male participants and five female participants) participated study, intakes ranging from 0.1 1.8 g/(kg·d). Each participant consumed an adapted diet a level 1.0 g/(kg·d) 1.7 resting energy expenditure (REE) 2 day. Day 3 day study. Diets that delivered at 1.5 × REE were isocaloric. amounts phenylalanine tyrosine maintained constant across intakes. Therefore, added doses 0.1–1.5 g/kg, which based on highest dose lactalbumin content [1.8 g/(kg·d)]. Applying non-linear mixed-effects model analysis F 13 CO , requirement determined identifying breakpoint data graded dietary protein. Results mean estimated average (EAR) recommended nutrient intake (RNI) 1.21 (95% CI: 0.95, 1.46) 1.54 1.13, 1.95) g/(kg·d), respectively. Conclusions To our knowledge, is first indicates require higher Clinical trial registration http://www.chictr.org.cn ChiCTR2200061383.

Language: Английский

Reply to DJ Millward DOI
Kerri Scherbinsky,

Ronald O. Ball,

Paul B. Pencharz

et al.

American Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: 121(2), P. 500 - 501

Published: Jan. 9, 2025

Language: Английский

Citations

1
Dietary protein requirements of older adults with sarcopenia determined by the indicator amino acid oxidation technology DOI Creative Commons
Wenxuan Wu,

Fengge Chen,

Hui Ma

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 28, 2025

Background Although protein supplementation may be desirable in the management of sarcopenia, appropriate requirements for older adults with sarcopenia are presently unclear. Objective The aim this study was to determine (65–81 year) by using indicator amino acid oxidation (IAAO) technology. Methods Nine (four male participants and five female participants) participated study, intakes ranging from 0.1 1.8 g/(kg·d). Each participant consumed an adapted diet a level 1.0 g/(kg·d) 1.7 resting energy expenditure (REE) 2 day. Day 3 day study. Diets that delivered at 1.5 × REE were isocaloric. amounts phenylalanine tyrosine maintained constant across intakes. Therefore, added doses 0.1–1.5 g/kg, which based on highest dose lactalbumin content [1.8 g/(kg·d)]. Applying non-linear mixed-effects model analysis F 13 CO , requirement determined identifying breakpoint data graded dietary protein. Results mean estimated average (EAR) recommended nutrient intake (RNI) 1.21 (95% CI: 0.95, 1.46) 1.54 1.13, 1.95) g/(kg·d), respectively. Conclusions To our knowledge, is first indicates require higher Clinical trial registration http://www.chictr.org.cn ChiCTR2200061383.

Language: Английский

Citations

0